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Items: 1 to 20 of 117

1.

Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells.

Neeft M, Wieffer M, de Jong AS, Negroiu G, Metz CH, van Loon A, Griffith J, Krijgsveld J, Wulffraat N, Koch H, Heck AJ, Brose N, Kleijmeer M, van der Sluijs P.

Mol Biol Cell. 2005 Feb;16(2):731-41. Epub 2004 Nov 17.

2.

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane.

Elstak ED, Neeft M, Nehme NT, Voortman J, Cheung M, Goodarzifard M, Gerritsen HC, van Bergen En Henegouwen PM, Callebaut I, de Saint Basile G, van der Sluijs P.

Blood. 2011 Aug 11;118(6):1570-8. doi: 10.1182/blood-2011-02-339523. Epub 2011 Jun 21.

3.

Methods for analysis of rab27a/Munc13-4 in secretory lysosome release in hematopoietic cells.

van der Sluijs P, Neeft M, van Vlijmen T, Elstak E, Wieffer M.

Methods Enzymol. 2008;438:185-201. doi: 10.1016/S0076-6879(07)38013-0.

PMID:
18413249
4.

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity.

Wood SM, Meeths M, Chiang SC, Bechensteen AG, Boelens JJ, Heilmann C, Horiuchi H, Rosthøj S, Rutynowska O, Winiarski J, Stow JL, Nordenskjöld M, Henter JI, Ljunggren HG, Bryceson YT.

Blood. 2009 Nov 5;114(19):4117-27. doi: 10.1182/blood-2009-06-225359. Epub 2009 Aug 24.

5.

Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.

Shirakawa R, Higashi T, Tabuchi A, Yoshioka A, Nishioka H, Fukuda M, Kita T, Horiuchi H.

J Biol Chem. 2004 Mar 12;279(11):10730-7. Epub 2003 Dec 29.

6.

Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.

Singh RK, Mizuno K, Wasmeier C, Wavre-Shapton ST, Recchi C, Catz SD, Futter C, Tolmachova T, Hume AN, Seabra MC.

FEBS J. 2013 Feb;280(3):892-903. doi: 10.1111/febs.12081. Epub 2013 Jan 2.

7.

Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells.

Kariya Y, Honma M, Hanamura A, Aoki S, Ninomiya T, Nakamichi Y, Udagawa N, Suzuki H.

J Bone Miner Res. 2011 Apr;26(4):689-703. doi: 10.1002/jbmr.268.

8.

Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.

Cetica V, Hackmann Y, Grieve S, Sieni E, Ciambotti B, Coniglio ML, Pende D, Gilmour K, Romagnoli P, Griffiths GM, Aricò M.

J Allergy Clin Immunol. 2015 May;135(5):1310-8.e1. doi: 10.1016/j.jaci.2014.08.039. Epub 2014 Oct 11.

9.

Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders.

Krzewski K, Cullinane AR.

Exp Cell Res. 2013 Sep 10;319(15):2360-7. doi: 10.1016/j.yexcr.2013.06.012. Epub 2013 Jun 26. Review.

10.

A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 function.

Elstak ED, te Loo M, Tesselaar K, van Kerkhof P, Loeffen J, Grivas D, Hennekam E, Boelens JJ, Hoogerbrugge PM, van der Sluijs P, van Gijn ME, van de Corput L.

Pediatr Blood Cancer. 2012 Apr;58(4):598-605. doi: 10.1002/pbc.23253. Epub 2011 Jul 13.

PMID:
21755595
11.

Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane.

Elstak ED, Neeft M, Nehme NT, Callebaut I, de Saint Basile G, van der Sluijs P.

Commun Integr Biol. 2012 Jan 1;5(1):64-7.

12.

Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells.

Higashio H, Nishimura N, Ishizaki H, Miyoshi J, Orita S, Sakane A, Sasaki T.

J Immunol. 2008 Apr 1;180(7):4774-84.

13.

Rab27a is required for regulated secretion in cytotoxic T lymphocytes.

Stinchcombe JC, Barral DC, Mules EH, Booth S, Hume AN, Machesky LM, Seabra MC, Griffiths GM.

J Cell Biol. 2001 Feb 19;152(4):825-34.

14.

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

Feldmann J, Callebaut I, Raposo G, Certain S, Bacq D, Dumont C, Lambert N, Ouachée-Chardin M, Chedeville G, Tamary H, Minard-Colin V, Vilmer E, Blanche S, Le Deist F, Fischer A, de Saint Basile G.

Cell. 2003 Nov 14;115(4):461-73.

15.

Cytotoxic T lymphocyte exocytosis: bring on the SNAREs!

Hong W.

Trends Cell Biol. 2005 Dec;15(12):644-50. Epub 2005 Nov 2.

PMID:
16260137
16.

Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism.

Saxena SK, Horiuchi H, Fukuda M.

Biochem Biophys Res Commun. 2006 Jun 2;344(2):651-7. Epub 2006 Apr 7.

PMID:
16630545
17.

Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes.

Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, Hoth M, Sester M, Krause E, Rettig J.

Traffic. 2013 Jul;14(7):798-809. doi: 10.1111/tra.12074. Epub 2013 May 9.

18.

Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice.

Haddad EK, Wu X, Hammer JA 3rd, Henkart PA.

J Cell Biol. 2001 Feb 19;152(4):835-42.

19.

The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.

Imai A, Yoshie S, Nashida T, Shimomura H, Fukuda M.

J Cell Sci. 2004 Apr 15;117(Pt 10):1945-53. Epub 2004 Mar 23.

20.

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.

Hume AN, Collinson LM, Hopkins CR, Strom M, Barral DC, Bossi G, Griffiths GM, Seabra MC.

Traffic. 2002 Mar;3(3):193-202.

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