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Results: 1 to 20 of 139

Similar articles for PubMed (Select 15482908)

1.

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.

Smith ND, Poon SF, Huang D, Green M, King C, Tehrani L, Roppe JR, Chung J, Chapman DP, Cramer M, Cosford ND.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5481-4.

PMID:
15482908
2.

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Poon SF, Eastman BW, Chapman DF, Chung J, Cramer M, Holtz G, Cosford ND, Smith ND.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5477-80.

PMID:
15482907
3.

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Huang D, Poon SF, Chapman DF, Chung J, Cramer M, Reger TS, Roppe JR, Tehrani L, Cosford ND, Smith ND.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5473-6.

PMID:
15482906
4.

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

Roppe J, Smith ND, Huang D, Tehrani L, Wang B, Anderson J, Brodkin J, Chung J, Jiang X, King C, Munoz B, Varney MA, Prasit P, Cosford ND.

J Med Chem. 2004 Sep 9;47(19):4645-8.

PMID:
15341479
5.

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.

Spanka C, Glatthar R, Desrayaud S, Fendt M, Orain D, Troxler T, Vranesic I.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. doi: 10.1016/j.bmcl.2009.11.001. Epub 2009 Nov 5.

PMID:
19931453
6.

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.

Roppe JR, Wang B, Huang D, Tehrani L, Kamenecka T, Schweiger EJ, Anderson JJ, Brodkin J, Jiang X, Cramer M, Chung J, Reyes-Manalo G, Munoz B, Cosford ND.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6.

PMID:
15225713
7.

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA.

J Med Chem. 2003 Jan 16;46(2):204-6.

PMID:
12519057
8.

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.

Tehrani LR, Smith ND, Huang D, Poon SF, Roppe JR, Seiders TJ, Chapman DF, Chung J, Cramer M, Cosford ND.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5061-4. Epub 2005 Sep 23.

PMID:
16183275
9.

Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.

Ceccarelli SM, Jaeschke G, Buettelmann B, Huwyler J, Kolczewski S, Peters JU, Prinssen E, Porter R, Spooren W, Vieira E.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1302-6. Epub 2006 Dec 15.

PMID:
17189691
10.

Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists.

Kamenecka TM, Bonnefous C, Govek S, Vernier JM, Hutchinson J, Chung J, Reyes-Manalo G, Anderson JJ.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4350-3.

PMID:
16039855
11.

CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.

Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, Parrott N, Hoffmann G, Wettstein JG.

J Pharmacol Exp Ther. 2011 Nov;339(2):474-86. doi: 10.1124/jpet.111.185660. Epub 2011 Aug 17.

12.

Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.

Bonnefous C, Vernier JM, Hutchinson JH, Chung J, Reyes-Manalo G, Kamenecka T.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1197-200.

PMID:
15686941
13.

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.

Porter RH, Jaeschke G, Spooren W, Ballard TM, Büttelmann B, Kolczewski S, Peters JU, Prinssen E, Wichmann J, Vieira E, Mühlemann A, Gatti S, Mutel V, Malherbe P.

J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. Epub 2005 Jul 22.

14.

Effect of selective antagonists of group I metabotropic glutamate receptors on the micturition reflex in rats.

Guarneri L, Poggesi E, Angelico P, Farina P, Leonardi A, Clarke DE, Testa R.

BJU Int. 2008 Sep;102(7):890-8. doi: 10.1111/j.1464-410X.2008.07748.x. Epub 2008 May 16.

PMID:
18489527
15.

Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.

Hernández AS, Swartz SG, Slusarchyk D, Yan M, Seethala RK, Sleph P, Grover G, Dickinson K, Giupponi L, Harper TW, Humphreys WG, Longhi DA, Flynn N, Murphy BJ, Gordon DA, Biller SA, Robl JA, Tino JA.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2067-72. doi: 10.1016/j.bmcl.2008.01.100. Epub 2008 Jan 31.

PMID:
18282707
16.

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.

Jaeschke G, Porter R, Büttelmann B, Ceccarelli SM, Guba W, Kuhn B, Kolczewski S, Huwyler J, Mutel V, Peters JU, Ballard T, Prinssen E, Vieira E, Wichmann J, Spooren W.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1307-11. Epub 2006 Dec 15.

PMID:
17196387
17.

Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.

Bueno AB, Collado I, de Dios A, Domínguez C, Martín JA, Martín LM, Martínez-Grau MA, Montero C, Pedregal C, Catlow J, Coffey DS, Clay MP, Dantzig AH, Lindstrom T, Monn JA, Jiang H, Schoepp DD, Stratford RE, Tabas LB, Tizzano JP, Wright RA, Herin MF.

J Med Chem. 2005 Aug 11;48(16):5305-20.

PMID:
16078848
18.

Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.

Carroll FI.

Ann N Y Acad Sci. 2008 Oct;1141:221-32. doi: 10.1196/annals.1441.015. Review.

PMID:
18991960
19.

Discovery of novel modulators of metabotropic glutamate receptor subtype-5.

Wang B, Vernier JM, Rao S, Chung J, Anderson JJ, Brodkin JD, Jiang X, Gardner MF, Yang X, Munoz B.

Bioorg Med Chem. 2004 Jan 2;12(1):17-21.

PMID:
14697765
20.

Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.

Chua PC, Nagasawa JY, Bleicher LS, Munoz B, Schweiger EJ, Tehrani L, Anderson JJ, Cramer M, Chung J, Green MD, King CD, Reyes-Manalo G, Cosford ND.

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4589-93.

PMID:
16115767
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