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Items: 1 to 20 of 253


Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation.

Mitchell J, Smith GC, Curtin NJ.

Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. doi: 10.1016/j.ijrobp.2009.07.1722.


Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

Curtin NJ, Wang LZ, Yiakouvaki A, Kyle S, Arris CA, Canan-Koch S, Webber SE, Durkacz BW, Calvert HA, Hostomsky Z, Newell DR.

Clin Cancer Res. 2004 Feb 1;10(3):881-9.


Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.

Löser DA, Shibata A, Shibata AK, Woodbine LJ, Jeggo PA, Chalmers AJ.

Mol Cancer Ther. 2010 Jun;9(6):1775-87. doi: 10.1158/1535-7163.MCT-09-1027. Epub 2010 Jun 8.


Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro.

Ariumi Y, Masutani M, Copeland TD, Mimori T, Sugimura T, Shimotohno K, Ueda K, Hatanaka M, Noda M.

Oncogene. 1999 Aug 12;18(32):4616-25.


PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.

Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G.

Nucleic Acids Res. 2006;34(21):6170-82. Epub 2006 Nov 6.


Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

Calabrese CR, Almassy R, Barton S, Batey MA, Calvert AH, Canan-Koch S, Durkacz BW, Hostomsky Z, Kumpf RA, Kyle S, Li J, Maegley K, Newell DR, Notarianni E, Stratford IJ, Skalitzky D, Thomas HD, Wang LZ, Webber SE, Williams KJ, Curtin NJ.

J Natl Cancer Inst. 2004 Jan 7;96(1):56-67.


Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation.

Fernet M, Ponette V, Deniaud-Alexandre E, Ménissier-De Murcia J, De Murcia G, Giocanti N, Megnin-Chanet F, Favaudon V.

Int J Radiat Biol. 2000 Dec;76(12):1621-9.


Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.

Ruscetti T, Lehnert BE, Halbrook J, Le Trong H, Hoekstra MF, Chen DJ, Peterson SR.

J Biol Chem. 1998 Jun 5;273(23):14461-7.


Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

Yoon JH, Ahn SG, Lee BH, Jung SH, Oh SH.

Biochem Pharmacol. 2012 Mar 15;83(6):747-57. doi: 10.1016/j.bcp.2011.12.029. Epub 2011 Dec 29.


Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

Zhao Y, Thomas HD, Batey MA, Cowell IG, Richardson CJ, Griffin RJ, Calvert AH, Newell DR, Smith GC, Curtin NJ.

Cancer Res. 2006 May 15;66(10):5354-62.


Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

Wang H, Zeng ZC, Bui TA, DiBiase SJ, Qin W, Xia F, Powell SN, Iliakis G.

Cancer Res. 2001 Jan 1;61(1):270-7.


Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

Thomas HD, Calabrese CR, Batey MA, Canan S, Hostomsky Z, Kyle S, Maegley KA, Newell DR, Skalitzky D, Wang LZ, Webber SE, Curtin NJ.

Mol Cancer Ther. 2007 Mar;6(3):945-56.


Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction.

Oliveira NG, Castro M, Rodrigues AS, Gonçalves IC, Martins C, Toscano Rico JM, Rueff J.

Mutat Res. 2005 May 2;583(1):36-48. Epub 2005 Apr 21.

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