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Results: 1 to 20 of 251

1.

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.

Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP.

Cell. 2004 Jul 9;118(1):83-97.

PMID:
15242646
[PubMed - indexed for MEDLINE]
Free Article
2.

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

Harper JW.

Cell. 2004 Jul 9;118(1):2-4.

PMID:
15242638
[PubMed - indexed for MEDLINE]
Free Article
3.

Inhibition of p53 degradation by Mdm2 acetylation.

Wang X, Taplick J, Geva N, Oren M.

FEBS Lett. 2004 Mar 12;561(1-3):195-201.

PMID:
15013777
[PubMed - indexed for MEDLINE]
Free Article
4.

Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.

Singh RK, Iyappan S, Scheffner M.

J Biol Chem. 2007 Apr 13;282(15):10901-7. Epub 2007 Feb 14.

PMID:
17301054
[PubMed - indexed for MEDLINE]
Free Article
5.

Critical contribution of the MDM2 acidic domain to p53 ubiquitination.

Kawai H, Wiederschain D, Yuan ZM.

Mol Cell Biol. 2003 Jul;23(14):4939-47.

PMID:
12832479
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination.

Badciong JC, Haas AL.

J Biol Chem. 2002 Dec 20;277(51):49668-75. Epub 2002 Oct 21.

PMID:
12393902
[PubMed - indexed for MEDLINE]
Free Article
7.

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.

Rodriguez MS, Desterro JM, Lain S, Lane DP, Hay RT.

Mol Cell Biol. 2000 Nov;20(22):8458-67.

PMID:
11046142
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Regulation of p53 and MDM2 activity by MTBP.

Brady M, Vlatkovic N, Boyd MT.

Mol Cell Biol. 2005 Jan;25(2):545-53.

PMID:
15632057
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.

Honda R, Tanaka H, Yasuda H.

FEBS Lett. 1997 Dec 22;420(1):25-7.

PMID:
9450543
[PubMed - indexed for MEDLINE]
Free Article
10.

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.

Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM.

J Biol Chem. 2000 Mar 24;275(12):8945-51.

PMID:
10722742
[PubMed - indexed for MEDLINE]
Free Article
11.

The Mdm-2 amino terminus is required for Mdm2 binding and SUMO-1 conjugation by the E2 SUMO-1 conjugating enzyme Ubc9.

Buschmann T, Lerner D, Lee CG, Ronai Z.

J Biol Chem. 2001 Nov 2;276(44):40389-95. Epub 2001 May 30.

PMID:
11384992
[PubMed - indexed for MEDLINE]
Free Article
12.

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W.

Science. 2003 Dec 12;302(5652):1972-5.

PMID:
14671306
[PubMed - indexed for MEDLINE]
Free Article
13.

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

Buschmann T, Fuchs SY, Lee CG, Pan ZQ, Ronai Z.

Cell. 2000 Jun 23;101(7):753-62. Erratum in: Cell 2001 Nov 16;107(4):549. Retraction in: Fuchs SY, Lee CG, Pan ZQ, Ronai Z. Cell. 2002 Aug 23;110(4):531.

PMID:
10892746
[PubMed - indexed for MEDLINE]
Free Article
14.

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase.

Honda R, Yasuda H.

Oncogene. 2000 Mar 9;19(11):1473-6.

PMID:
10723139
[PubMed - indexed for MEDLINE]
Free Article
15.

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.

Okamoto K, Taya Y, Nakagama H.

FEBS Lett. 2009 Sep 3;583(17):2710-4. doi: 10.1016/j.febslet.2009.07.021. Epub 2009 Jul 18.

PMID:
19619542
[PubMed - indexed for MEDLINE]
Free Article
16.

NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways.

Liu G, Xirodimas DP.

Oncogene. 2010 Apr 15;29(15):2252-61. doi: 10.1038/onc.2009.494. Epub 2010 Jan 25.

PMID:
20101219
[PubMed - indexed for MEDLINE]
17.

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP.

J Biol Chem. 2004 Oct 1;279(40):42169-81. Epub 2004 Jul 26.

PMID:
15280377
[PubMed - indexed for MEDLINE]
Free Article
18.

The ubiquitin ligase COP1 is a critical negative regulator of p53.

Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM.

Nature. 2004 May 6;429(6987):86-92. Epub 2004 Apr 21.

PMID:
15103385
[PubMed - indexed for MEDLINE]
19.

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.

Stad R, Little NA, Xirodimas DP, Frenk R, van der Eb AJ, Lane DP, Saville MK, Jochemsen AG.

EMBO Rep. 2001 Nov;2(11):1029-34. Epub 2001 Oct 17.

PMID:
11606419
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation.

Stommel JM, Wahl GM.

EMBO J. 2004 Apr 7;23(7):1547-56. Epub 2004 Mar 18.

PMID:
15029243
[PubMed - indexed for MEDLINE]
Free PMC Article

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