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Results: 1 to 20 of 161

1.

The Sir2 family of protein deacetylases.

Blander G, Guarente L.

Annu Rev Biochem. 2004;73:417-35. Review.

PMID:
15189148
[PubMed - indexed for MEDLINE]
2.

SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates.

Sauve AA, Schramm VL.

Curr Med Chem. 2004 Apr;11(7):807-26. Review.

PMID:
15078167
[PubMed - indexed for MEDLINE]
3.

Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases.

Khan AN, Lewis PN.

J Biol Chem. 2006 Apr 28;281(17):11702-11. Epub 2006 Mar 6.

PMID:
16520376
[PubMed - indexed for MEDLINE]
Free Article
4.

Sir Antagonist 1 (San1) is a ubiquitin ligase.

Dasgupta A, Ramsey KL, Smith JS, Auble DT.

J Biol Chem. 2004 Jun 25;279(26):26830-8. Epub 2004 Apr 12.

PMID:
15078868
[PubMed - indexed for MEDLINE]
Free Article
5.

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.

Borra MT, Langer MR, Slama JT, Denu JM.

Biochemistry. 2004 Aug 3;43(30):9877-87.

PMID:
15274642
[PubMed - indexed for MEDLINE]
6.

Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.

Zhao K, Harshaw R, Chai X, Marmorstein R.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8563-8. Epub 2004 May 18.

PMID:
15150415
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions.

Tanny JC, Kirkpatrick DS, Gerber SA, Gygi SP, Moazed D.

Mol Cell Biol. 2004 Aug;24(16):6931-46.

PMID:
15282295
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3.

Chang JF, Hall BE, Tanny JC, Moazed D, Filman D, Ellenberger T.

Structure. 2003 Jun;11(6):637-49. Erratum in: Structure (Camb). 2004 Aug;12(8):1547.

PMID:
12791253
[PubMed - indexed for MEDLINE]
9.

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme.

Avalos JL, Bever KM, Wolberger C.

Mol Cell. 2005 Mar 18;17(6):855-68.

PMID:
15780941
[PubMed - indexed for MEDLINE]
Free Article
10.

Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing.

Chou CC, Li YC, Gartenberg MR.

Mol Cell. 2008 Sep 5;31(5):650-9. doi: 10.1016/j.molcel.2008.06.020.

PMID:
18775325
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation.

Hoppe GJ, Tanny JC, Rudner AD, Gerber SA, Danaie S, Gygi SP, Moazed D.

Mol Cell Biol. 2002 Jun;22(12):4167-80.

PMID:
12024030
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

J Biol Chem. 2002 Nov 22;277(47):45099-107. Epub 2002 Sep 23.

PMID:
12297502
[PubMed - indexed for MEDLINE]
Free Article
13.

Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases.

Mead J, McCord R, Youngster L, Sharma M, Gartenberg MR, Vershon AK.

Mol Cell Biol. 2007 Apr;27(7):2466-75. Epub 2007 Jan 22.

PMID:
17242192
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin.

Rudner AD, Hall BE, Ellenberger T, Moazed D.

Mol Cell Biol. 2005 Jun;25(11):4514-28.

PMID:
15899856
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation.

Liou GG, Tanny JC, Kruger RG, Walz T, Moazed D.

Cell. 2005 May 20;121(4):515-27.

PMID:
15907466
[PubMed - indexed for MEDLINE]
Free Article
16.

SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex.

Furuyama T, Banerjee R, Breen TR, Harte PJ.

Curr Biol. 2004 Oct 26;14(20):1812-21.

PMID:
15498488
[PubMed - indexed for MEDLINE]
17.

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.

Imai S, Armstrong CM, Kaeberlein M, Guarente L.

Nature. 2000 Feb 17;403(6771):795-800.

PMID:
10693811
[PubMed - indexed for MEDLINE]
18.

Structural basis for the NAD-dependent deacetylase mechanism of Sir2.

Chang JH, Kim HC, Hwang KY, Lee JW, Jackson SP, Bell SD, Cho Y.

J Biol Chem. 2002 Sep 13;277(37):34489-98. Epub 2002 Jun 28.

PMID:
12091395
[PubMed - indexed for MEDLINE]
Free Article
19.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.

PMID:
12939617
[PubMed - indexed for MEDLINE]
20.

Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases.

Marmorstein R.

Biochem Soc Trans. 2004 Dec;32(Pt 6):904-9. Review.

PMID:
15506920
[PubMed - indexed for MEDLINE]
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