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Results: 1 to 20 of 114

1.

Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.

Sabb AL, Vogel RL, Welmaker GS, Sabalski JE, Coupet J, Dunlop J, Rosenzweig-Lipson S, Harrison B.

Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7.

PMID:
15109661
[PubMed - indexed for MEDLINE]
2.

WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity.

Dunlop J, Sabb AL, Mazandarani H, Zhang J, Kalgaonker S, Shukhina E, Sukoff S, Vogel RL, Stack G, Schechter L, Harrison BL, Rosenzweig-Lipson S.

J Pharmacol Exp Ther. 2005 May;313(2):862-9. Epub 2005 Feb 10.

PMID:
15705738
[PubMed - indexed for MEDLINE]
Free Article
3.

Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.

Röver S, Adams DR, Bénardeau A, Bentley JM, Bickerdike MJ, Bourson A, Cliffe IA, Coassolo P, Davidson JE, Dourish CT, Hebeisen P, Kennett GA, Knight AR, Malcolm CS, Mattei P, Misra A, Mizrahi J, Muller M, Porter RH, Richter H, Taylor S, Vickers SP.

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3604-8.

PMID:
15975787
[PubMed - indexed for MEDLINE]
4.

Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.

Thomsen WJ, Grottick AJ, Menzaghi F, Reyes-Saldana H, Espitia S, Yuskin D, Whelan K, Martin M, Morgan M, Chen W, Al-Shamma H, Smith B, Chalmers D, Behan D.

J Pharmacol Exp Ther. 2008 May;325(2):577-87. doi: 10.1124/jpet.107.133348. Epub 2008 Feb 5.

PMID:
18252809
[PubMed - indexed for MEDLINE]
Free Article
5.

The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist.

Huck BR, Llamas L, Robarge MJ, Dent TC, Song J, Hodnick WF, Crumrine C, Stricker-Krongrad A, Harrington J, Brunden KR, Bennani YL.

Bioorg Med Chem Lett. 2006 Aug 1;16(15):4130-4. Epub 2006 Jun 5.

PMID:
16750364
[PubMed - indexed for MEDLINE]
6.

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.

Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, Gaster LM, Ham P, Jones GE, King FD, Mulholland KR, Saunders DV, Wyman PA, Blaney FE, Clarke SE, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Trail B, Riley GJ, Wood MD.

J Med Chem. 2000 Mar 23;43(6):1123-34.

PMID:
10737744
[PubMed - indexed for MEDLINE]
7.

Indoline derivatives as 5-HT(2C) receptor agonists.

Bentley JM, Adams DR, Bebbington D, Benwell KR, Bickerdike MJ, Davidson JE, Dawson CE, Dourish CT, Duncton MA, Gaur S, George AR, Giles PR, Hamlyn RJ, Kennett GA, Knight AR, Malcolm CS, Mansell HL, Misra A, Monck NJ, Pratt RM, Quirk K, Roffey JR, Vickers SP, Cliffe IA.

Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70.

PMID:
15081042
[PubMed - indexed for MEDLINE]
8.

2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists.

Ennis MD, Hoffman RL, Ghazal NB, Olson RM, Knauer CS, Chio CL, Hyslop DK, Campbell JE, Fitzgerald LW, Nichols NF, Svensson KA, McCall RB, Haber CL, Kagey ML, Dinh DM.

Bioorg Med Chem Lett. 2003 Jul 21;13(14):2369-72.

PMID:
12824036
[PubMed - indexed for MEDLINE]
9.

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.

Shimada I, Maeno K, Kazuta K, Kubota H, Kimizuka T, Kimura Y, Hatanaka K, Naitou Y, Wanibuchi F, Sakamoto S, Tsukamoto S.

Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. Epub 2007 Nov 4.

PMID:
18035544
[PubMed - indexed for MEDLINE]
10.

WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity.

Marquis KL, Sabb AL, Logue SF, Brennan JA, Piesla MJ, Comery TA, Grauer SM, Ashby CR Jr, Nguyen HQ, Dawson LA, Barrett JE, Stack G, Meltzer HY, Harrison BL, Rosenzweig-Lipson S.

J Pharmacol Exp Ther. 2007 Jan;320(1):486-96. Epub 2006 Oct 12.

PMID:
17038512
[PubMed - indexed for MEDLINE]
Free Article
11.

Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

Fletcher PJ, Tampakeras M, Sinyard J, Slassi A, Isaac M, Higgins GA.

Neuropharmacology. 2009 Sep;57(3):259-67. doi: 10.1016/j.neuropharm.2009.05.011. Epub 2009 Jun 6.

PMID:
19501602
[PubMed - indexed for MEDLINE]
12.

Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse.

Dalton GL, Lee MD, Kennett GA, Dourish CT, Clifton PG.

Psychopharmacology (Berl). 2006 Mar;185(1):45-57. Epub 2006 Feb 10.

PMID:
16470405
[PubMed - indexed for MEDLINE]
13.

Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.

Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Thomsen WJ, Saldana HR, Whelan KT, Menzaghi F, Webb RR, Beeley NR.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1467-70.

PMID:
15713408
[PubMed - indexed for MEDLINE]
14.

SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.

Sard H, Kumaran G, Morency C, Roth BL, Toth BA, He P, Shuster L.

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.

PMID:
16061378
[PubMed - indexed for MEDLINE]
15.

Design and synthesis of pyridazinone-based 5-HT(2C) agonists.

Allerton CM, Andrews MD, Blagg J, Ellis D, Evrard E, Green MP, Liu KK, McMurray G, Ralph M, Sanderson V, Ward R, Watson L.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5791-5. doi: 10.1016/j.bmcl.2009.07.136. Epub 2009 Aug 6.

PMID:
19716297
[PubMed - indexed for MEDLINE]
16.

Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes.

Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A.

Assay Drug Dev Technol. 2005 Dec;3(6):649-59.

PMID:
16438660
[PubMed - indexed for MEDLINE]
17.

Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.

Shimada I, Maeno K, Kondoh Y, Kaku H, Sugasawa K, Kimura Y, Hatanaka K, Naitou Y, Wanibuchi F, Sakamoto S, Tsukamoto S.

Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. Epub 2007 Dec 8.

PMID:
18083579
[PubMed - indexed for MEDLINE]
18.

Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone.

Harada K, Aota M, Inoue T, Matsuda R, Mihara T, Yamaji T, Ishibashi K, Matsuoka N.

Eur J Pharmacol. 2006 Dec 28;553(1-3):171-84. Epub 2006 Sep 28.

PMID:
17074317
[PubMed - indexed for MEDLINE]
19.

Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503.

Rosenzweig-Lipson S, Zhang J, Mazandarani H, Harrison BL, Sabb A, Sabalski J, Stack G, Welmaker G, Barrett JE, Dunlop J.

Brain Res. 2006 Feb 16;1073-1074:240-51. Epub 2006 Jan 20.

PMID:
16430874
[PubMed - indexed for MEDLINE]
20.

Design, synthesis and biological activity of novel dimethyl-[2-[6-substituted-indol-1-yl]-ethyl]-amine as potent, selective, and orally-bioavailable 5-HT(1D) agonists.

Isaac M, Slassi M, Xin T, Arora J, O'Brien A, Edwards L, MacLean N, Wilson J, Demschyshyn L, Labrie P, Naismith A, Maddaford S, Papac D, Harrison S, Wang H, Draper S, Tehim A.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4409-13.

PMID:
14643336
[PubMed - indexed for MEDLINE]

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