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Results: 1 to 20 of 245

1.

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1.

Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED, Häring HU, Lehmann R.

J Biol Chem. 2004 Jun 11;279(24):25157-63. Epub 2004 Apr 5.

PMID:
15069075
[PubMed - indexed for MEDLINE]
Free Article
2.

In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites.

Sommerfeld MR, Metzger S, Stosik M, Tennagels N, Eckel J.

Biochemistry. 2004 May 18;43(19):5888-901.

PMID:
15134463
[PubMed - indexed for MEDLINE]
3.

The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal.

Weigert C, Hennige AM, Brischmann T, Beck A, Moeschel K, Schaüble M, Brodbeck K, Häring HU, Schleicher ED, Lehmann R.

J Biol Chem. 2005 Nov 11;280(45):37393-9. Epub 2005 Aug 29.

PMID:
16129678
[PubMed - indexed for MEDLINE]
Free Article
4.

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).

Aguirre V, Uchida T, Yenush L, Davis R, White MF.

J Biol Chem. 2000 Mar 24;275(12):9047-54.

PMID:
10722755
[PubMed - indexed for MEDLINE]
Free Article
5.

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.

Liberman Z, Eldar-Finkelman H.

J Biol Chem. 2005 Feb 11;280(6):4422-8. Epub 2004 Nov 30.

PMID:
15574412
[PubMed - indexed for MEDLINE]
Free Article
7.

14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.

Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T.

J Biol Chem. 1997 Oct 3;272(40):25267-74.

PMID:
9312143
[PubMed - indexed for MEDLINE]
Free Article
8.

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.

Waraich RS, Weigert C, Kalbacher H, Hennige AM, Lutz SZ, Häring HU, Schleicher ED, Voelter W, Lehmann R.

J Biol Chem. 2008 Apr 25;283(17):11226-33. doi: 10.1074/jbc.M708588200. Epub 2008 Feb 19.

PMID:
18285345
[PubMed - indexed for MEDLINE]
Free Article
9.
10.

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.

Liu YF, Paz K, Herschkovitz A, Alt A, Tennenbaum T, Sampson SR, Ohba M, Kuroki T, LeRoith D, Zick Y.

J Biol Chem. 2001 Apr 27;276(17):14459-65. Epub 2001 Jan 29.

PMID:
11278339
[PubMed - indexed for MEDLINE]
Free Article
11.

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

De Fea K, Roth RA.

Biochemistry. 1997 Oct 21;36(42):12939-47.

PMID:
9335553
[PubMed - indexed for MEDLINE]
12.

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.

Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y.

J Biol Chem. 1999 Oct 1;274(40):28816-22.

PMID:
10497255
[PubMed - indexed for MEDLINE]
Free Article
13.

Expression and function of IRS-1 in insulin signal transmission.

Sun XJ, Miralpeix M, Myers MG Jr, Glasheen EM, Backer JM, Kahn CR, White MF.

J Biol Chem. 1992 Nov 5;267(31):22662-72.

PMID:
1385403
[PubMed - indexed for MEDLINE]
Free Article
14.

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta.

Greene MW, Morrice N, Garofalo RS, Roth RA.

Biochem J. 2004 Feb 15;378(Pt 1):105-16.

PMID:
14583092
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

Ravichandran LV, Esposito DL, Chen J, Quon MJ.

J Biol Chem. 2001 Feb 2;276(5):3543-9. Epub 2000 Nov 3.

PMID:
11063744
[PubMed - indexed for MEDLINE]
Free Article
16.

Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.

Bossenmaier B, Strack V, Stoyanov B, Krützfeldt J, Beck A, Lehmann R, Kellerer M, Klein H, Ullrich A, Lammers R, Häring HU.

Diabetes. 2000 Jun;49(6):889-95.

PMID:
10866039
[PubMed - indexed for MEDLINE]
Free Article
17.

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Häring HU.

Diabetologia. 1998 Jul;41(7):833-8.

PMID:
9686926
[PubMed - indexed for MEDLINE]
18.

Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.

Müssig K, Staiger H, Fiedler H, Moeschel K, Beck A, Kellerer M, Häring HU.

J Biol Chem. 2005 Sep 23;280(38):32693-9. Epub 2005 Jul 29.

PMID:
16055440
[PubMed - indexed for MEDLINE]
Free Article
19.

Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

Tanasijevic MJ, Myers MG Jr, Thoma RS, Crimmins DL, White MF, Sacks DB.

J Biol Chem. 1993 Aug 25;268(24):18157-66.

PMID:
8349691
[PubMed - indexed for MEDLINE]
Free Article
20.

Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo.

Giorgino F, Almahfouz A, Goodyear LJ, Smith RJ.

J Clin Invest. 1993 May;91(5):2020-30.

PMID:
7683695
[PubMed - indexed for MEDLINE]
Free PMC Article

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