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Items: 1 to 20 of 102


Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.

Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR.

J Cell Biol. 2004 Feb 2;164(3):461-70.


Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.

Mor A, Wynne JP, Ahearn IM, Dustin ML, Du G, Philips MR.

Mol Cell Biol. 2009 Jun;29(12):3297-306. doi: 10.1128/MCB.00366-09. Epub 2009 Mar 30.


Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.

Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR.

J Cell Biol. 2012 Oct 15;199(2):317-30. doi: 10.1083/jcb.201201157. Epub 2012 Oct 8.


Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.

Nomura K, Kanemura H, Satoh T, Kataoka T.

J Biol Chem. 2004 May 21;279(21):22664-73. Epub 2004 Mar 18.


Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling.

Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T.

J Biol Chem. 2001 Aug 10;276(32):30301-7. Epub 2001 Jun 6.


Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1.

Kloog Y, Mor A.

Mol Cell Biol. 2014 Mar;34(6):978-88. doi: 10.1128/MCB.01024-13. Epub 2014 Jan 6.


Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

Medeiros RB, Dickey DM, Chung H, Quale AC, Nagarajan LR, Billadeau DD, Shimizu Y.

Immunity. 2005 Aug;23(2):213-26.


Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration.

Miertzschke M, Stanley P, Bunney TD, Rodrigues-Lima F, Hogg N, Katan M.

J Biol Chem. 2007 Oct 19;282(42):30629-42. Epub 2007 Aug 23.


Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells.

Jeon TJ, Lee DJ, Lee S, Weeks G, Firtel RA.

J Cell Biol. 2007 Dec 3;179(5):833-43. Epub 2007 Nov 26.


The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

Reedquist KA, Ross E, Koop EA, Wolthuis RM, Zwartkruis FJ, van Kooyk Y, Salmon M, Buckley CD, Bos JL.

J Cell Biol. 2000 Mar 20;148(6):1151-8.


RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.

Ménasché G, Kliche S, Chen EJ, Stradal TE, Schraven B, Koretzky G.

Mol Cell Biol. 2007 Jun;27(11):4070-81. Epub 2007 Apr 2.


Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.

Hisata S, Sakisaka T, Baba T, Yamada T, Aoki K, Matsuda M, Takai Y.

J Cell Biol. 2007 Aug 27;178(5):843-60.


Rap1 GTPase: functions, regulation, and malignancy.

Hattori M, Minato N.

J Biochem. 2003 Oct;134(4):479-84. Review.


Nerve growth factor activates persistent Rap1 signaling in endosomes.

Wu C, Lai CF, Mobley WC.

J Neurosci. 2001 Aug 1;21(15):5406-16.


The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.

Yoshikawa Y, Satoh T, Tamura T, Wei P, Bilasy SE, Edamatsu H, Aiba A, Katagiri K, Kinashi T, Nakao K, Kataoka T.

Mol Biol Cell. 2007 Aug;18(8):2949-59. Epub 2007 May 30.


F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.

Caloca MJ, Zugaza JL, Vicente-Manzanares M, Sánchez-Madrid F, Bustelo XR.

J Biol Chem. 2004 May 7;279(19):20435-46. Epub 2004 Feb 26.

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