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Results: 1 to 20 of 232

1.

Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.

Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL.

J Pharmacol Exp Ther. 2004 Mar;308(3):1197-203. Epub 2004 Jan 8.

PMID:
14718611
[PubMed - indexed for MEDLINE]
Free Article
2.

Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.

Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11934-9. Epub 2002 Aug 21.

PMID:
12192085
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.

Ansonoff MA, Zhang J, Czyzyk T, Rothman RB, Stewart J, Xu H, Zjwiony J, Siebert DJ, Yang F, Roth BL, Pintar JE.

J Pharmacol Exp Ther. 2006 Aug;318(2):641-8. Epub 2006 May 3.

PMID:
16672569
[PubMed - indexed for MEDLINE]
Free Article
4.

Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.

Fantegrossi WE, Kugle KM, Valdes LJ 3rd, Koreeda M, Woods JH.

Behav Pharmacol. 2005 Dec;16(8):627-33.

PMID:
16286814
[PubMed - indexed for MEDLINE]
5.

The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys.

Butelman ER, Harris TJ, Kreek MJ.

Psychopharmacology (Berl). 2004 Mar;172(2):220-4. Epub 2003 Oct 30.

PMID:
14586540
[PubMed - indexed for MEDLINE]
6.

The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice.

Capasso R, Borrelli F, Zjawiony J, Kutrzeba L, Aviello G, Sarnelli G, Capasso F, Izzo AA.

Neurogastroenterol Motil. 2008 Feb;20(2):142-8. Epub 2007 Sep 4.

PMID:
17931335
[PubMed - indexed for MEDLINE]
7.

Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo.

Wang Y, Tang K, Inan S, Siebert D, Holzgrabe U, Lee DY, Huang P, Li JG, Cowan A, Liu-Chen LY.

J Pharmacol Exp Ther. 2005 Jan;312(1):220-30. Epub 2004 Sep 21.

PMID:
15383632
[PubMed - indexed for MEDLINE]
Free Article
8.

Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors.

Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ.

Psychopharmacology (Berl). 2005 May;179(3):551-8. Epub 2005 Jan 29.

PMID:
15682306
[PubMed - indexed for MEDLINE]
9.

Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats.

Baker LE, Panos JJ, Killinger BA, Peet MM, Bell LM, Haliw LA, Walker SL.

Psychopharmacology (Berl). 2009 Apr;203(2):203-11. doi: 10.1007/s00213-008-1458-3. Epub 2009 Jan 20.

PMID:
19153716
[PubMed - indexed for MEDLINE]
10.

Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.

Vortherms TA, Mosier PD, Westkaemper RB, Roth BL.

J Biol Chem. 2007 Feb 2;282(5):3146-56. Epub 2006 Nov 22.

PMID:
17121830
[PubMed - indexed for MEDLINE]
Free Article
11.

The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats.

Willmore-Fordham CB, Krall DM, McCurdy CR, Kinder DH.

Neuropharmacology. 2007 Sep;53(4):481-6. Epub 2007 Jun 27.

PMID:
17681558
[PubMed - indexed for MEDLINE]
12.

Salvinorin A: from natural product to human therapeutics.

Vortherms TA, Roth BL.

Mol Interv. 2006 Oct;6(5):257-65. Review.

PMID:
17035666
[PubMed - indexed for MEDLINE]
13.

Salvinorin A: a novel and highly selective kappa-opioid receptor agonist.

Yan F, Roth BL.

Life Sci. 2004 Oct 15;75(22):2615-9. Review.

PMID:
15369697
[PubMed - indexed for MEDLINE]
14.

Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.

Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL.

Biochemistry. 2005 Jun 21;44(24):8643-51.

PMID:
15952771
[PubMed - indexed for MEDLINE]
15.

Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans.

Butelman ER, Mandau M, Tidgewell K, Prisinzano TE, Yuferov V, Kreek MJ.

J Pharmacol Exp Ther. 2007 Jan;320(1):300-6. Epub 2006 Oct 23.

PMID:
17060493
[PubMed - indexed for MEDLINE]
Free Article
16.

A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist.

Kane BE, Nieto MJ, McCurdy CR, Ferguson DM.

FEBS J. 2006 May;273(9):1966-74.

PMID:
16640560
[PubMed - indexed for MEDLINE]
17.

Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues.

Lee DY, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA Jr, Cohen B.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5498-502. Epub 2006 Aug 30. Erratum in: Bioorg Med Chem Lett. 2008 Mar 15;18(6):2227.

PMID:
16945525
[PubMed - indexed for MEDLINE]
18.

Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues.

Lee DY, Karnati VV, He M, Liu-Chen LY, Kondaveti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA Jr, Cohen B.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3744-7.

PMID:
15993589
[PubMed - indexed for MEDLINE]
19.

Salvia divinorum and salvinorin A: an update on pharmacology and analytical methodology.

Grundmann O, Phipps SM, Zadezensky I, Butterweck V.

Planta Med. 2007 Aug;73(10):1039-46. Epub 2007 Jul 12. Review. Erratum in: Planta Med. 2007 Aug;73(10):1139.

PMID:
17628834
[PubMed - indexed for MEDLINE]
20.

Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands.

Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE.

J Med Chem. 2005 Jul 28;48(15):4765-71.

PMID:
16033256
[PubMed - indexed for MEDLINE]

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