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Results: 1 to 20 of 138

1.

The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase.

Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS.

Biochem J. 2004 Apr 1;379(Pt 1):107-18.

PMID:
14705961
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Ecotin is a potent anticoagulant and reversible tight-binding inhibitor of factor Xa.

Seymour JL, Lindquist RN, Dennis MS, Moffat B, Yansura D, Reilly D, Wessinger ME, Lazarus RA.

Biochemistry. 1994 Apr 5;33(13):3949-58.

PMID:
8142399
[PubMed - indexed for MEDLINE]
3.

The P1 reactive site methionine residue of ecotin is not crucial for its specificity on target proteases. A potent inhibitor of pancreatic serine proteases from Escherichia coli.

Seong IS, Lee HR, Seol JH, Park SK, Lee CS, Suh SW, Hong YM, Kang MS, Ha DB, Chung CH.

J Biol Chem. 1994 Aug 26;269(34):21915-8.

PMID:
8063835
[PubMed - indexed for MEDLINE]
Free Article
4.

The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.

McGrath ME, Hines WM, Sakanari JA, Fletterick RJ, Craik CS.

J Biol Chem. 1991 Apr 5;266(10):6620-5.

PMID:
2007606
[PubMed - indexed for MEDLINE]
Free Article
5.

Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator.

Yang SQ, Craik CS.

J Mol Biol. 1998 Jun 19;279(4):1001-11.

PMID:
9642077
[PubMed - indexed for MEDLINE]
6.

Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.

Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ.

J Mol Biol. 2000 Jun 16;299(4):993-1003.

PMID:
10843853
[PubMed - indexed for MEDLINE]
7.

Ecotin: lessons on survival in a protease-filled world.

McGrath ME, Gillmor SA, Fletterick RJ.

Protein Sci. 1995 Feb;4(2):141-8. Review.

PMID:
7757004
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis.

Pál G, Sprengel G, Patthy A, Gráf L.

FEBS Lett. 1994 Mar 28;342(1):57-60.

PMID:
8143850
[PubMed - indexed for MEDLINE]
Free Article
9.

Engineering ecotin for identifying proteins with a trypsin fold.

Sathler PC, Craik CS, Takeuchi T, Zingali RB, Castro HC.

Appl Biochem Biotechnol. 2010 Apr;160(8):2355-65. doi: 10.1007/s12010-009-8711-z. Epub 2009 Aug 30.

PMID:
19728173
[PubMed - indexed for MEDLINE]
10.

The role of ecotin dimerization in protease inhibition.

Eggers CT, Wang SX, Fletterick RJ, Craik CS.

J Mol Biol. 2001 May 18;308(5):975-91.

PMID:
11352586
[PubMed - indexed for MEDLINE]
11.

Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin.

Wang CI, Yang Q, Craik CS.

J Biol Chem. 1995 May 19;270(20):12250-6.

PMID:
7744876
[PubMed - indexed for MEDLINE]
Free Article
12.

Ecotin: a serine protease inhibitor with two distinct and interacting binding sites.

Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS.

J Mol Biol. 1998 Jun 19;279(4):945-57.

PMID:
9642073
[PubMed - indexed for MEDLINE]
13.

The contribution of key hydrophobic residues in ecotin to enzyme-inhibitor complex stability.

McCrudden MT, Ryan LA, Turkington P, Timson DJ.

J Enzyme Inhib Med Chem. 2009 Dec;24(6):1207-10. doi: 10.3109/14756360902779458.

PMID:
19912053
[PubMed - indexed for MEDLINE]
14.

Ecotin is a potent inhibitor of the contact system proteases factor XIIa and plasma kallikrein.

Ulmer JS, Lindquist RN, Dennis MS, Lazarus RA.

FEBS Lett. 1995 May 29;365(2-3):159-63.

PMID:
7781771
[PubMed - indexed for MEDLINE]
Free Article
15.

Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases.

Chung CH, Ives HE, Almeda S, Goldberg AL.

J Biol Chem. 1983 Sep 25;258(18):11032-8.

PMID:
6411724
[PubMed - indexed for MEDLINE]
Free Article
16.

Ecotin modulates thrombin activity through exosite-2 interactions.

Castro HC, Monteiro RQ, Assafim M, Loureiro NI, Craik C, Zingali RB.

Int J Biochem Cell Biol. 2006;38(11):1893-900. Epub 2006 May 17.

PMID:
16843700
[PubMed - indexed for MEDLINE]
17.

Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis.

Clark EA, Walker N, Ford DC, Cooper IA, Oyston PC, Acharya KR.

J Biol Chem. 2011 Jul 8;286(27):24015-22. doi: 10.1074/jbc.M111.225730. Epub 2011 Apr 29.

PMID:
21531711
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform?

Castro HC, Silva DM, Craik C, Zingali RB.

Biochim Biophys Acta. 2001 Jun 11;1547(2):183-95.

PMID:
11410274
[PubMed - indexed for MEDLINE]
Free Article
19.

Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions.

Wang SX, Esmon CT, Fletterick RJ.

Biochemistry. 2001 Aug 28;40(34):10038-46.

PMID:
11513582
[PubMed - indexed for MEDLINE]
20.

Engineering of a macromolecular scaffold to develop specific protease inhibitors.

Stoop AA, Craik CS.

Nat Biotechnol. 2003 Sep;21(9):1063-8. Epub 2003 Aug 17.

PMID:
12923547
[PubMed - indexed for MEDLINE]

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