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Items: 1 to 20 of 205

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Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study.

Hou H, Khan N, O'Hara JA, Grinberg OY, Dunn JF, Abajian MA, Wilmot CM, Makki M, Demidenko E, Lu S, Steffen RP, Swartz HM.

Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):834-43.

PMID:
15183487
4.

Increasing P(50) does not improve DO(2CRIT) or systemic VO(2) in severe anemia.

Eichelbrönner O, D'Almeida M, Sielenkämper A, Sibbald WJ, Chin-Yee IH.

Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H92-101.

5.

Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat.

Grocott HP, Bart RD, Sheng H, Miura Y, Steffen R, Pearlstein RD, Warner DS.

Stroke. 1998 Aug;29(8):1650-5.

6.

Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study.

Hou H, Khan N, O'Hara JA, Grinberg OY, Dunn JF, Abajian MA, Wilmot CM, Demidenko E, Lu S, Steffen RP, Swartz HM.

Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1503-9.

PMID:
15817356
7.

RSR13, a synthetic modifier of hemoglobin-oxygen affinity, enhances the recovery of stunned myocardium in anesthetized dogs.

Pagel PS, Hettrick DA, Montgomery MW, Kersten JR, Steffen RP, Warltier DC.

J Pharmacol Exp Ther. 1998 Apr;285(1):1-8.

8.

RSR13, a synthetic allosteric modifier of hemoglobin, improves myocardial recovery following hypothermic cardiopulmonary bypass.

Kilgore KS, Shwartz CF, Gallagher MA, Steffen RP, Mosca RS, Bolling SF.

Circulation. 1999 Nov 9;100(19 Suppl):II351-6.

9.

Effects of FI(O(2)) on hemodynamic responses and O(2) transport during RSR13-induced reduction in P(50).

Eichelbrönner O, Sielenkämper A, D'Almeida M, Ellis CG, Sibbald WJ, Chin-Yee IH.

Am J Physiol. 1999 Jul;277(1 Pt 2):H290-8.

10.

Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat.

Sarraf-Yazdi S, Sheng H, Grocott HP, Bart RD, Pearlstein RD, Steffen RP, Warner DS.

Brain Res. 1999 May 1;826(2):172-80.

PMID:
10224294
11.

Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation.

Khandelwal SR, Randad RS, Lin PS, Meng H, Pittman RN, Kontos HA, Choi SC, Abraham DJ, Schmidt-Ullrich R.

Am J Physiol. 1993 Oct;265(4 Pt 2):H1450-3.

PMID:
8238433
13.

Enhancement of tumor oxygenation and radiation response by the allosteric effector of hemoglobin, RSR13.

Amorino GP, Lee H, Holburn GE, Paschal CB, Hercules SK, Shyr Y, Steffen RP, Choy H.

Radiat Res. 2001 Sep;156(3):294-300.

PMID:
11500138
14.

Allosteric modification of hemoglobin by RSR13 as a therapeutic strategy.

Steffen RP, Liard JF, Gerber MJ, Hoffman SJ.

Adv Exp Med Biol. 2003;530:249-59.

PMID:
14562722
15.

Phase I trial to determine the safety, pharmacodynamics, and pharmacokinetics of RSR13, a novel radioenhancer, in newly diagnosed glioblastoma multiforme.

Kleinberg L, Grossman SA, Piantadosi S, Pearlman J, Engelhard H, Lesser G, Ruffer J, Gerber M.

J Clin Oncol. 1999 Aug;17(8):2593-603.

PMID:
10561327
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Low-affinity hemoglobin increases tissue PO2 and decreases arteriolar diameter and flow in the rat cremaster muscle.

Kunert MP, Liard JF, Abraham DJ, Lombard JH.

Microvasc Res. 1996 Jul;52(1):58-68.

PMID:
8812756
18.

Effect of an allosteric modifier of hemoglobin, RSR-4, on oxygen affinity and oxygen saturation of hemoglobin in rabbits.

Uchida K, Reilly MP, Abraham DJ, Asakura T.

Jpn J Physiol. 1998 Dec;48(6):439-44.

PMID:
10021497
19.

Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on microcirculation and local tissue pO2 of striated skin muscle following resuscitation from hemorrhagic shock.

Hungerer S, Nolte D, Botzlar A, Messmer K.

Artif Cells Blood Substit Immobil Biotechnol. 2006;34(5):455-71.

PMID:
16893810
20.

Effects of a pharmacologically-induced shift of hemoglobin-oxygen dissociation on myocardial energetics during ischemia in patients with coronary artery disease.

Najjar SS, Bottomley PA, Schulman SP, Waldron MM, Steffen RP, Gerstenblith G, Weiss RG.

J Cardiovasc Magn Reson. 2005;7(4):657-66.

PMID:
16136855
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