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CpG content affects gene silencing in mice: evidence from novel transgenes.

Chevalier-Mariette C, Henry I, Montfort L, Capgras S, Forlani S, Muschler J, Nicolas JF.

Genome Biol. 2003;4(9):R53. Epub 2003 Aug 14.


A novel imprinted transgene located near a repetitive element that exhibits allelic imbalance in DNA methylation during early development.

Uchiyama K, Watanabe D, Hayasaka M, Hanaoka K.

Dev Growth Differ. 2014 Dec;56(9):653-68. doi: 10.1111/dgd.12182. Epub 2014 Nov 11.


Pre-selection of integration sites imparts repeatable transgene expression.

Wallace H, Ansell R, Clark J, McWhir J.

Nucleic Acids Res. 2000 Mar 15;28(6):1455-64.


CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.

Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, Wu YZ, Rodriguez B, Keller B, Liyanarachchi S, Wei G, Davuluri RV, Weinstein M, Felsher D, Ostrowski M, Leone G, Plass C.

PLoS Genet. 2007 Sep;3(9):1757-69. Epub 2007 Aug 16.


Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation.

Chen ZY, Riu E, He CY, Xu H, Kay MA.

Mol Ther. 2008 Mar;16(3):548-56. doi: 10.1038/ Epub 2008 Feb 5.


Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.

Yuan J, Luo RZ, Fujii S, Wang L, Hu W, Andreeff M, Pan Y, Kadota M, Oshimura M, Sahin AA, Issa JP, Bast RC Jr, Yu Y.

Cancer Res. 2003 Jul 15;63(14):4174-80.


Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.

Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP.

PLoS Genet. 2007 Oct;3(10):2023-36. Epub 2007 Sep 10.


Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.

Kirov JV, Adkisson M, Nava AJ, Cipollone A, Willis B, Engelhard EK, Lloyd KC, de Jong P, West DB.

PLoS One. 2015 Aug 14;10(8):e0134155. doi: 10.1371/journal.pone.0134155. eCollection 2015.


Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent.

Müller C, Readhead C, Diederichs S, Idos G, Yang R, Tidow N, Serve H, Berdel WE, Koeffler HP.

Mol Cell Biol. 2000 May;20(9):3316-29.


Distal transgene insertion affects CpG island maintenance during differentiation.

Strathdee D, Whitelaw CB, Clark AJ.

J Biol Chem. 2008 Apr 25;283(17):11509-15. doi: 10.1074/jbc.M709805200. Epub 2008 Feb 28.


DNA methylation of Sleeping Beauty with transposition into the mouse genome.

Park CW, Kren BT, Largaespada DA, Steer CJ.

Genes Cells. 2005 Aug;10(8):763-76.


DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter.

Han H, Cortez CC, Yang X, Nichols PW, Jones PA, Liang G.

Hum Mol Genet. 2011 Nov 15;20(22):4299-310. doi: 10.1093/hmg/ddr356. Epub 2011 Aug 11.


Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island.

Zhang Y, Shu J, Si J, Shen L, Estecio MR, Issa JP.

Nucleic Acids Res. 2012 Aug;40(15):7257-68. Epub 2012 May 17.


Targeting of >1.5 Mb of human DNA into the mouse X chromosome reveals presence of cis-acting regulators of epigenetic silencing.

Yang C, McLeod AJ, Cotton AM, de Leeuw CN, Laprise S, Banks KG, Simpson EM, Brown CJ.

Genetics. 2012 Dec;192(4):1281-93. doi: 10.1534/genetics.112.143743. Epub 2012 Sep 28.


lacZ sequences prevent regulated expression of housekeeping genes.

Cohen-Tannoudji M, Vandormael-Pournin S, Drezen J, Mercier P, Babinet C, Morello D.

Mech Dev. 2000 Jan;90(1):29-39.


Repeat-induced gene silencing of L1 transgenes is correlated with differential promoter methylation.

Rosser JM, An W.

Gene. 2010 May 15;456(1-2):15-23. doi: 10.1016/j.gene.2010.02.005. Epub 2010 Feb 16.


A globin enhancer acts by increasing the proportion of erythrocytes expressing a linked transgene.

Sutherland HG, Martin DI, Whitelaw E.

Mol Cell Biol. 1997 Mar;17(3):1607-14.

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