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Hypoxia induces apoptosis in SV40-immortalized rat proximal tubular cells through the mitochondrial pathways, devoid of HIF1-mediated upregulation of Bax.

Tanaka T, Hanafusa N, Ingelfinger JR, Ohse T, Fujita T, Nangaku M.

Biochem Biophys Res Commun. 2003 Sep 12;309(1):222-31.


Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling.

Yang CC, Lin LC, Wu MS, Chien CT, Lai MK.

Transplantation. 2009 Dec 15;88(11):1251-60. doi: 10.1097/TP.0b013e3181bb4a07.


Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.

D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C.

J Biol Chem. 2003 Oct 3;278(40):38183-7. Epub 2003 Jul 21.


DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells.

Kang MJ, Jung SM, Kim MJ, Bae JH, Kim HB, Kim JY, Park SJ, Song HS, Kim DW, Kang CD, Kim SH.

FEBS J. 2008 Dec;275(23):5969-81. doi: 10.1111/j.1742-4658.2008.06725.x.


Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy.

Yeh CH, Hsu SP, Yang CC, Chien CT, Wang NP.

Life Sci. 2010 Jan 16;86(3-4):115-23. doi: 10.1016/j.lfs.2009.11.022. Epub 2009 Dec 4.


Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells.

Santore MT, McClintock DS, Lee VY, Budinger GR, Chandel NS.

Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L727-34.


Involvement of the mitochondrial pathway in cold storage and rewarming-associated apoptosis of human renal proximal tubular cells.

Salahudeen AK, Huang H, Joshi M, Moore NA, Jenkins JK.

Am J Transplant. 2003 Mar;3(3):273-80.


BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.

Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA, Gibson SB.

Oncogene. 2003 Jul 24;22(30):4734-44.


A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis.

Mizutani A, Furukawa T, Adachi Y, Ikehara S, Taketani S.

J Biol Chem. 2002 May 3;277(18):15851-8. Epub 2002 Feb 6.


Inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells.

Dai S, Huang ML, Hsu CY, Chao KS.

Int J Radiat Oncol Biol Phys. 2003 Mar 15;55(4):1027-36. Erratum in: Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):604.


Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria.

Wang J, Wei Q, Wang CY, Hill WD, Hess DC, Dong Z.

J Biol Chem. 2004 May 7;279(19):19948-54. Epub 2004 Mar 5.


Adenovirus-mediated bcl-2 gene transfer inhibits renal ischemia/reperfusion induced tubular oxidative stress and apoptosis.

Chien CT, Chang TC, Tsai CY, Shyue SK, Lai MK.

Am J Transplant. 2005 Jun;5(6):1194-203. Erratum in: Am J Transplant. 2006 Feb;6(2):444. Chiang-Ting, Chien [corrected to Chien, Chiang-Ting]; Tzu-Ching, Chang [corrected to Chang, Tzu-Ching]; Ching-Yi, Tsai [corrected to Tsai, Ching-Yi]; Song-Kuen, Shyue [corrected to Shyue, Song-Kuen]; Ming-Kuen, Lai [corrected to Lai, Ming-Kuen].


Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.

Pyrzynska B, Serrano M, Martínez-A C, Kaminska B.

J Biol Chem. 2002 Apr 19;277(16):14102-8. Epub 2002 Feb 4.


Differential gene expression in apoptosis: identification of ribosomal protein S29 as an apoptotic inducer.

Khanna N, Reddy VG, Tuteja N, Singh N.

Biochem Biophys Res Commun. 2000 Oct 22;277(2):476-86.


HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE.

EMBO J. 2004 May 5;23(9):1949-56. Epub 2004 Apr 8.


Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells.

Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T.

J Biol Chem. 2004 Feb 13;279(7):6017-26. Epub 2003 Nov 18.


c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.

Brunelle JK, Santore MT, Budinger GR, Tang Y, Barrett TA, Zong WX, Kandel E, Keith B, Simon MC, Thompson CB, Hay N, Chandel NS.

J Biol Chem. 2004 Feb 6;279(6):4305-12. Epub 2003 Nov 19.

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