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Results: 1 to 20 of 404

1.

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor.

Jung KM, Tan S, Landman N, Petrova K, Murray S, Lewis R, Kim PK, Kim DS, Ryu SH, Chao MV, Kim TW.

J Biol Chem. 2003 Oct 24;278(43):42161-9. Epub 2003 Aug 11.

PMID:
12913006
[PubMed - indexed for MEDLINE]
Free Article
2.

Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.

Kanning KC, Hudson M, Amieux PS, Wiley JC, Bothwell M, Schecterson LC.

J Neurosci. 2003 Jul 2;23(13):5425-36.

PMID:
12843241
[PubMed - indexed for MEDLINE]
Free Article
3.

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.

Zampieri N, Xu CF, Neubert TA, Chao MV.

J Biol Chem. 2005 Apr 15;280(15):14563-71. Epub 2005 Feb 8.

PMID:
15701642
[PubMed - indexed for MEDLINE]
Free Article
4.

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.

LaVoie MJ, Selkoe DJ.

J Biol Chem. 2003 Sep 5;278(36):34427-37. Epub 2003 Jun 25.

PMID:
12826675
[PubMed - indexed for MEDLINE]
Free Article
5.

Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD.

Gowrishankar K, Zeidler MG, Vincenz C.

J Cell Sci. 2004 Aug 15;117(Pt 18):4099-111. Epub 2004 Jul 27.

PMID:
15280425
[PubMed - indexed for MEDLINE]
Free Article
6.

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C.

J Biol Chem. 2002 Nov 22;277(47):44754-9. Epub 2002 Sep 9.

PMID:
12223485
[PubMed - indexed for MEDLINE]
Free Article
7.

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.

Cervantes S, Saura CA, Pomares E, Gonzàlez-Duarte R, Marfany G.

J Biol Chem. 2004 Aug 27;279(35):36519-29. Epub 2004 Jun 25.

PMID:
15220354
[PubMed - indexed for MEDLINE]
Free Article
8.

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.

Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P.

J Biol Chem. 2002 Sep 27;277(39):36521-6. Epub 2002 Jul 15.

PMID:
12119298
[PubMed - indexed for MEDLINE]
Free Article
9.

TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain.

Urra S, Escudero CA, Ramos P, Lisbona F, Allende E, Covarrubias P, Parraguez JI, Zampieri N, Chao MV, Annaert W, Bronfman FC.

J Biol Chem. 2007 Mar 9;282(10):7606-15. Epub 2007 Jan 9.

PMID:
17215246
[PubMed - indexed for MEDLINE]
Free Article
10.

Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor.

Powell JC, Twomey C, Jain R, McCarthy JV.

J Neurochem. 2009 Jan;108(1):216-30. doi: 10.1111/j.1471-4159.2008.05763.x. Epub 2008 Nov 22.

PMID:
19012753
[PubMed - indexed for MEDLINE]
11.

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT.

J Neurochem. 2000 Aug;75(2):583-93.

PMID:
10899933
[PubMed - indexed for MEDLINE]
12.

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS.

Biochemistry. 2003 Jan 14;42(1):137-44.

PMID:
12515548
[PubMed - indexed for MEDLINE]
13.

Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase.

Underwood CK, Reid K, May LM, Bartlett PF, Coulson EJ.

Mol Cell Neurosci. 2008 Feb;37(2):346-58. Epub 2007 Oct 23.

PMID:
18055214
[PubMed - indexed for MEDLINE]
14.

The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase.

Sykes AM, Palstra N, Abankwa D, Hill JM, Skeldal S, Matusica D, Venkatraman P, Hancock JF, Coulson EJ.

J Biol Chem. 2012 Dec 21;287(52):43810-24. doi: 10.1074/jbc.M112.382903. Epub 2012 Oct 26.

PMID:
23105112
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule.

Zou Z, Chung B, Nguyen T, Mentone S, Thomson B, Biemesderfer D.

J Biol Chem. 2004 Aug 13;279(33):34302-10. Epub 2004 Jun 4.

PMID:
15180987
[PubMed - indexed for MEDLINE]
Free Article
16.

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

Ceni C, Kommaddi RP, Thomas R, Vereker E, Liu X, McPherson PS, Ritter B, Barker PA.

J Cell Sci. 2010 Jul 1;123(Pt 13):2299-307. doi: 10.1242/jcs.062612. Epub 2010 Jun 8.

PMID:
20530577
[PubMed - indexed for MEDLINE]
Free Article
17.

Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.

Elzinga BM, Twomey C, Powell JC, Harte F, McCarthy JV.

J Biol Chem. 2009 Jan 16;284(3):1394-409. doi: 10.1074/jbc.M803108200. Epub 2008 Nov 7.

PMID:
18996842
[PubMed - indexed for MEDLINE]
Free Article
18.

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage.

Kim DY, Ingano LA, Kovacs DM.

J Biol Chem. 2002 Dec 20;277(51):49976-81. Epub 2002 Oct 9.

PMID:
12376527
[PubMed - indexed for MEDLINE]
Free Article
19.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

PMID:
12960155
[PubMed - indexed for MEDLINE]
Free Article
20.

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O.

J Biol Chem. 2005 Jul 22;280(29):27303-9. Epub 2005 May 25.

PMID:
15917251
[PubMed - indexed for MEDLINE]
Free Article

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