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Results: 1 to 20 of 138

1.

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.

Castro AF, Rebhun JF, Clark GJ, Quilliam LA.

J Biol Chem. 2003 Aug 29;278(35):32493-6. Epub 2003 Jul 3.

PMID:
12842888
[PubMed - indexed for MEDLINE]
Free Article
2.

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.

Li Y, Inoki K, Guan KL.

Mol Cell Biol. 2004 Sep;24(18):7965-75.

PMID:
15340059
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.

PMID:
15150271
[PubMed - indexed for MEDLINE]
Free Article
4.

Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.

Finlay GA, Malhowski AJ, Liu Y, Fanburg BL, Kwiatkowski DJ, Toksoz D.

Cancer Res. 2007 Oct 15;67(20):9878-86.

PMID:
17942919
[PubMed - indexed for MEDLINE]
Free Article
5.

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG.

J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16.

PMID:
15772076
[PubMed - indexed for MEDLINE]
Free Article
6.

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J.

Curr Biol. 2003 Aug 5;13(15):1259-68.

PMID:
12906785
[PubMed - indexed for MEDLINE]
Free Article
7.

Rheb binds and regulates the mTOR kinase.

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

Curr Biol. 2005 Apr 26;15(8):702-13.

PMID:
15854902
[PubMed - indexed for MEDLINE]
Free Article
8.

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.

Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D.

Nat Cell Biol. 2003 Jun;5(6):578-81.

PMID:
12771962
[PubMed - indexed for MEDLINE]
9.

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Inoki K, Li Y, Xu T, Guan KL.

Genes Dev. 2003 Aug 1;17(15):1829-34. Epub 2003 Jul 17.

PMID:
12869586
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.

Robb VA, Astrinidis A, Henske EP.

Mod Pathol. 2006 Jun;19(6):839-46. Erratum in: Mod Pathol. 2006 Jun;19(6):889.

PMID:
16575396
[PubMed - indexed for MEDLINE]
Free Article
11.

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.

Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P.

J Biol Chem. 2005 Sep 2;280(35):31101-8. Epub 2005 Jul 8.

PMID:
16006564
[PubMed - indexed for MEDLINE]
Free Article
12.

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.

Shah OJ, Wang Z, Hunter T.

Curr Biol. 2004 Sep 21;14(18):1650-6.

PMID:
15380067
[PubMed - indexed for MEDLINE]
Free Article
13.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G.

Mol Cell. 2003 Jun;11(6):1457-66.

PMID:
12820960
[PubMed - indexed for MEDLINE]
Free Article
14.

The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.

Nobukini T, Thomas G.

Novartis Found Symp. 2004;262:148-54; discussion 154-9, 265-8. Review.

PMID:
15562827
[PubMed - indexed for MEDLINE]
15.

Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex.

Shah OJ, Hunter T.

J Biol Chem. 2004 May 14;279(20):20816-23. Epub 2004 Mar 1.

PMID:
14993219
[PubMed - indexed for MEDLINE]
Free Article
16.

Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.

Kwiatkowski DJ.

Cancer Biol Ther. 2003 Sep-Oct;2(5):471-6. Review.

PMID:
14614311
[PubMed - indexed for MEDLINE]
Free Article
17.

Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.

Gau CL, Kato-Stankiewicz J, Jiang C, Miyamoto S, Guo L, Tamanoi F.

Mol Cancer Ther. 2005 Jun;4(6):918-26.

PMID:
15956249
[PubMed - indexed for MEDLINE]
Free Article
18.

Measurements of TSC2 GAP activity toward Rheb.

Li Y, Inoki K, Vikis H, Guan KL.

Methods Enzymol. 2006;407:46-54.

PMID:
16757313
[PubMed - indexed for MEDLINE]
19.

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8286-91. doi: 10.1073/pnas.0712268105. Epub 2008 Jun 11.

PMID:
18550814
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.

Yang Q, Inoki K, Kim E, Guan KL.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6811-6. Epub 2006 Apr 20.

PMID:
16627617
[PubMed - indexed for MEDLINE]
Free PMC Article

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