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Results: 1 to 20 of 196

1.

Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells.

Liang JS, Kim T, Fang S, Yamaguchi J, Weissman AM, Fisher EA, Ginsberg HN.

J Biol Chem. 2003 Jun 27;278(26):23984-8. Epub 2003 Apr 1.

PMID:
12670940
[PubMed - indexed for MEDLINE]
Free Article
2.

Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein.

Zhou M, Fisher EA, Ginsberg HN.

J Biol Chem. 1998 Sep 18;273(38):24649-53.

PMID:
9733761
[PubMed - indexed for MEDLINE]
Free Article
3.

Ubiquitin-dependent and -independent proteasomal degradation of apoB associated with endoplasmic reticulum and Golgi apparatus, respectively, in HepG2 cells.

Liao W, Chang BH, Mancini M, Chan L.

J Cell Biochem. 2003 Aug 1;89(5):1019-29.

PMID:
12874835
[PubMed - indexed for MEDLINE]
4.

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum.

Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14422-7. Epub 2001 Nov 27.

PMID:
11724934
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus.

Rutledge AC, Qiu W, Zhang R, Kohen-Avramoglu R, Nemat-Gorgani N, Adeli K.

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):579-85. doi: 10.1161/ATVBAHA.108.181859. Epub 2009 Jan 22.

PMID:
19164805
[PubMed - indexed for MEDLINE]
Free Article
6.

Overexpression of the endoplasmic reticulum 60 protein ER-60 downregulates apoB100 secretion by inducing its intracellular degradation via a nonproteasomal pathway: evidence for an ER-60-mediated and pCMB-sensitive intracellular degradative pathway.

Qiu W, Kohen-Avramoglu R, Rashid-Kolvear F, Au CS, Chong TM, Lewis GF, Trinh DK, Austin RC, Urade R, Adeli K.

Biochemistry. 2004 Apr 27;43(16):4819-31.

PMID:
15096051
[PubMed - indexed for MEDLINE]
7.

Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation.

Qiu W, Kohen-Avramoglu R, Mhapsekar S, Tsai J, Austin RC, Adeli K.

Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):571-7. Epub 2004 Dec 23.

PMID:
15618547
[PubMed - indexed for MEDLINE]
Free Article
8.

Cytosolic components are required for proteasomal degradation of newly synthesized apolipoprotein B in permeabilized HepG2 cells.

Sakata N, Stoops JD, Dixon JL.

J Biol Chem. 1999 Jun 11;274(24):17068-74.

PMID:
10358059
[PubMed - indexed for MEDLINE]
Free Article
9.

Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway.

Fisher EA, Khanna NA, McLeod RS.

J Lipid Res. 2011 Jun;52(6):1170-80. doi: 10.1194/jlr.M011726. Epub 2011 Mar 18.

PMID:
21421992
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70.

Fisher EA, Zhou M, Mitchell DM, Wu X, Omura S, Wang H, Goldberg AL, Ginsberg HN.

J Biol Chem. 1997 Aug 15;272(33):20427-34.

PMID:
9252351
[PubMed - indexed for MEDLINE]
Free Article
12.

Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.

Lindén D, Lindberg K, Oscarsson J, Claesson C, Asp L, Li L, Gustafsson M, Borén J, Olofsson SO.

J Biol Chem. 2002 Jun 21;277(25):23044-53. Epub 2002 Mar 29.

PMID:
11925428
[PubMed - indexed for MEDLINE]
Free Article
13.

Demonstration of biphasic effects of docosahexaenoic acid on apolipoprotein B secretion in HepG2 cells.

Wu X, Shang A, Jiang H, Ginsberg HN.

Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):3347-55.

PMID:
9409332
[PubMed - indexed for MEDLINE]
Free Article
14.

Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway.

Wang Q, Theriault A, Gapor A, Adeli K.

Biochem Biophys Res Commun. 1998 May 29;246(3):640-3.

PMID:
9618265
[PubMed - indexed for MEDLINE]
15.

Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.

Gusarova V, Caplan AJ, Brodsky JL, Fisher EA.

J Biol Chem. 2001 Jul 6;276(27):24891-900. Epub 2001 May 1.

PMID:
11333259
[PubMed - indexed for MEDLINE]
Free Article
16.

AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation.

Zhong X, Shen Y, Ballar P, Apostolou A, Agami R, Fang S.

J Biol Chem. 2004 Oct 29;279(44):45676-84. Epub 2004 Aug 24.

PMID:
15331598
[PubMed - indexed for MEDLINE]
Free Article
17.

Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.

Chen Y, Le Cahérec F, Chuck SL.

J Biol Chem. 1998 May 8;273(19):11887-94.

PMID:
9565615
[PubMed - indexed for MEDLINE]
Free Article
18.

Conformational changes in apolipoprotein B modulate intracellular assembly and degradation of ApoB-containing lipoprotein particles in HepG2 cells.

Macri J, Adeli K.

Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2982-94.

PMID:
9409285
[PubMed - indexed for MEDLINE]
Free Article
19.

Efficient glycosylation site utilization by intracellular apolipoprotein B. Implications for proteasomal degradation.

Huang XF, Shelness GS.

J Lipid Res. 1999 Dec;40(12):2212-22.

PMID:
10588947
[PubMed - indexed for MEDLINE]
Free Article
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