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Results: 1 to 20 of 141

1.

Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.

Huse JT, Byant D, Yang Y, Pijak DS, D'Souza I, Lah JJ, Lee VM, Doms RW, Cook DG.

J Biol Chem. 2003 May 9;278(19):17141-9. Epub 2003 Jan 27.

PMID:
12551920
[PubMed - indexed for MEDLINE]
Free Article
2.

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase.

Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW.

J Biol Chem. 2000 Oct 27;275(43):33729-37.

PMID:
10924510
[PubMed - indexed for MEDLINE]
Free Article
3.

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.

Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R.

J Biol Chem. 2000 Dec 1;275(48):37712-7. Erratum in: J Biol Chem 2001 May 4;276(18):15561.

PMID:
10956649
[PubMed - indexed for MEDLINE]
Free Article
4.

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ.

J Biol Chem. 2003 Jun 6;278(23):21286-94. Epub 2003 Mar 27.

PMID:
12665519
[PubMed - indexed for MEDLINE]
Free Article
5.

Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.

Gandhi S, Refolo LM, Sambamurti K.

J Mol Neurosci. 2004;24(1):137-43.

PMID:
15314262
[PubMed - indexed for MEDLINE]
6.

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity.

Fischer F, Molinari M, Bodendorf U, Paganetti P.

J Neurochem. 2002 Mar;80(6):1079-88.

PMID:
11953458
[PubMed - indexed for MEDLINE]
7.

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chr├ętien M, Seidah NG.

J Biol Chem. 2001 Apr 6;276(14):10879-87. Epub 2001 Jan 10.

PMID:
11152688
[PubMed - indexed for MEDLINE]
Free Article
8.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT.

J Neurosci. 2006 Jan 11;26(2):418-28.

PMID:
16407538
[PubMed - indexed for MEDLINE]
Free Article
9.

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

Marlow L, Cain M, Pappolla MA, Sambamurti K.

J Mol Neurosci. 2003;20(3):233-9.

PMID:
14501002
[PubMed - indexed for MEDLINE]
10.

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.

Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C.

J Biol Chem. 2004 Dec 17;279(51):53205-12. Epub 2004 Oct 12.

PMID:
15485862
[PubMed - indexed for MEDLINE]
Free Article
11.

Characterization of recombinant, soluble beta-secretase from an insect cell expression system.

Mallender WD, Yager D, Onstead L, Nichols MR, Eckman C, Sambamurti K, Kopcho LM, Marcinkeviciene J, Copeland RA, Rosenberry TL.

Mol Pharmacol. 2001 Mar;59(3):619-26.

PMID:
11179458
[PubMed - indexed for MEDLINE]
Free Article
12.

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.

Fukumoto H, Cheung BS, Hyman BT, Irizarry MC.

Arch Neurol. 2002 Sep;59(9):1381-9.

PMID:
12223024
[PubMed - indexed for MEDLINE]
13.

Human BACE forms dimers and colocalizes with APP.

Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G.

J Biol Chem. 2004 Sep 17;279(38):39710-7. Epub 2004 Jul 9.

PMID:
15247262
[PubMed - indexed for MEDLINE]
Free Article
14.

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.

Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M.

J Biol Chem. 2000 Jul 14;275(28):21099-106.

PMID:
10887202
[PubMed - indexed for MEDLINE]
Free Article
15.

Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.

Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, Ramamurthy V, Morin PE, Camac DM, King RW, Lasut AL, Ross OH, Hillman MC, Fish B, Shen K, Dowling RL, Kim YB, Graciani NR, Collins D, Combs AP, George H, Thompson LA, Copeland RA.

Arch Biochem Biophys. 2003 Feb 15;410(2):307-16.

PMID:
12573291
[PubMed - indexed for MEDLINE]
16.

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.

Liu K, Doms RW, Lee VM.

Biochemistry. 2002 Mar 5;41(9):3128-36.

PMID:
11863452
[PubMed - indexed for MEDLINE]
17.

Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?

Nawrot B.

Acta Biochim Pol. 2004;51(2):431-44. Review.

PMID:
15218540
[PubMed - indexed for MEDLINE]
Free Article
18.

A non-amyloidogenic function of BACE-2 in the secretory pathway.

Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J.

J Neurochem. 2002 Jun;81(5):1011-20.

PMID:
12065613
[PubMed - indexed for MEDLINE]
19.

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.

Huse JT, Liu K, Pijak DS, Carlin D, Lee VM, Doms RW.

J Biol Chem. 2002 May 3;277(18):16278-84. Epub 2002 Feb 14.

PMID:
11847218
[PubMed - indexed for MEDLINE]
Free Article
20.

Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli.

Emmons TL, Mildner AM, Lull JM, Leone JW, Fischer HD, Heinrikson RL, Tomasselli AG.

Protein Pept Lett. 2009;16(2):121-31.

PMID:
19200034
[PubMed - indexed for MEDLINE]

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