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Results: 1 to 20 of 257

1.

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2003 Feb;52(2):568-72.

PMID:
12540637
[PubMed - indexed for MEDLINE]
Free Article
2.

Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses.

van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ.

Diabet Med. 2005 May;22(5):590-8.

PMID:
15842514
[PubMed - indexed for MEDLINE]
3.

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC; UK Prospective Diabetes Study (UKPDS 53).

Diabet Med. 2001 Mar;18(3):206-12. Erratum in: Diabet Med. 2003 Mar;20(3):252..

PMID:
11318841
[PubMed - indexed for MEDLINE]
4.

Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.

Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S.

Diabetes. 2006 Aug;55(8):2379-86.

PMID:
16873704
[PubMed - indexed for MEDLINE]
Free Article
5.

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

Diabetes. 2004 May;53(5):1360-8.

PMID:
15111507
[PubMed - indexed for MEDLINE]
Free Article
6.

Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.

Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, Shestakova MV, Nosikov VV.

Acta Diabetol. 2009 Mar;46(1):43-9. doi: 10.1007/s00592-008-0056-5. Epub 2008 Aug 29.

PMID:
18758683
[PubMed - indexed for MEDLINE]
7.

Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes.

Elbein SC, Sun J, Scroggin E, Teng K, Hasstedt SJ.

Diabetes Care. 2001 Mar;24(3):472-8.

PMID:
11289470
[PubMed - indexed for MEDLINE]
8.

Effects of single nucleotide polymorphisms in K(ATP) channel genes on type 2 diabetes in a Turkish population.

Gonen MS, Arikoglu H, Erkoc Kaya D, Ozdemir H, Ipekci SH, Arslan A, Kayis SA, Gogebakan B.

Arch Med Res. 2012 May;43(4):317-23. doi: 10.1016/j.arcmed.2012.06.001. Epub 2012 Jun 13.

PMID:
22704848
[PubMed - indexed for MEDLINE]
9.

SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population.

Sakamoto Y, Inoue H, Keshavarz P, Miyawaki K, Yamaguchi Y, Moritani M, Kunika K, Nakamura N, Yoshikawa T, Yasui N, Shiota H, Tanahashi T, Itakura M.

J Hum Genet. 2007;52(10):781-93. Epub 2007 Sep 6.

PMID:
17823772
[PubMed - indexed for MEDLINE]
10.

The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population.

Zhou D, Zhang D, Liu Y, Zhao T, Chen Z, Liu Z, Yu L, Zhang Z, Xu H, He L.

J Hum Genet. 2009 Jul;54(7):433-5. doi: 10.1038/jhg.2009.54. Epub 2009 Jun 5.

PMID:
19498446
[PubMed - indexed for MEDLINE]
11.

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.

Hansen T, Echwald SM, Hansen L, Møller AM, Almind K, Clausen JO, Urhammer SA, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt MA, Pedersen O.

Diabetes. 1998 Apr;47(4):598-605.

PMID:
9568693
[PubMed - indexed for MEDLINE]
12.

Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population.

Wang F, Han XY, Ren Q, Zhang XY, Han LC, Luo YY, Zhou XH, Ji LN.

Chin Med J (Engl). 2009 Oct 20;122(20):2477-82.

PMID:
20079163
[PubMed - indexed for MEDLINE]
Free Article
13.

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.

Diabetes. 2009 Oct;58(10):2419-24. doi: 10.2337/db09-0143. Epub 2009 Jul 8.

PMID:
19587354
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.

Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, Froguel P.

Diabetologia. 1998 Dec;41(12):1511-5.

PMID:
9867219
[PubMed - indexed for MEDLINE]
15.

Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.

Barber TM, Bennett AJ, Gloyn AL, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Taponen S, Weedon MN, Hartikainen AL, Wass JA, Järvelin MR, Zeggini E, Franks S, McCarthy MI.

Eur J Hum Genet. 2007 Jun;15(6):679-84. Epub 2007 Mar 7.

PMID:
17342155
[PubMed - indexed for MEDLINE]
Free Article
16.

Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.

Shaat N, Ekelund M, Lernmark A, Ivarsson S, Almgren P, Berntorp K, Groop L.

Diabetologia. 2005 Dec;48(12):2544-51. Epub 2005 Nov 17.

PMID:
16320083
[PubMed - indexed for MEDLINE]
17.

Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients.

He YY, Zhang R, Shao XY, Hu C, Wang CR, Lu JX, Bao YQ, Jia WP, Xiang KS.

Acta Pharmacol Sin. 2008 Aug;29(8):983-9. doi: 10.1111/j.1745-7254.2008.00840.x.

PMID:
18664331
[PubMed - indexed for MEDLINE]
Free Article
18.

Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women.

Qi L, van Dam RM, Asselbergs FW, Hu FB.

Diabet Med. 2007 Nov;24(11):1187-91. Epub 2007 Sep 26.

PMID:
17894829
[PubMed - indexed for MEDLINE]
19.

Metabolic control in type 2 diabetes is associated with sulfonylurea receptor-1 (SUR-1) but not with KCNJ11 polymorphisms.

Nikolac N, Simundic AM, Katalinic D, Topic E, Cipak A, Zjacic Rotkvic V.

Arch Med Res. 2009 Jul;40(5):387-92. doi: 10.1016/j.arcmed.2009.06.006.

PMID:
19766903
[PubMed - indexed for MEDLINE]
20.

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

Diabetes. 2003 Feb;52(2):573-7.

PMID:
12540638
[PubMed - indexed for MEDLINE]
Free Article

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