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Items: 1 to 20 of 105

1.

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.

Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK.

Am J Pathol. 2002 Nov;161(5):1869-79.

2.

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK.

J Neurosci. 2004 Apr 7;24(14):3592-9.

3.

Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.

Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E.

FEBS J. 2010 Jul;277(14):3051-67. doi: 10.1111/j.1742-4658.2010.07719.x. Epub 2010 Jun 22.

4.

Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease.

Capetillo-Zarate E, Gracia L, Tampellini D, Gouras GK.

Neurodegener Dis. 2012;10(1-4):56-9. doi: 10.1159/000334762. Epub 2012 Jan 21.

PMID:
22269167
5.

Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.

Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK.

PLoS One. 2013;8(1):e51965. doi: 10.1371/journal.pone.0051965. Epub 2013 Jan 23.

6.

Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.

Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Yan XX.

Eur J Neurosci. 2009 Dec;30(12):2271-83. doi: 10.1111/j.1460-9568.2009.07017.x. Epub 2009 Dec 10.

7.

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.

Youmans KL, Tai LM, Kanekiyo T, Stine WB Jr, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ.

Mol Neurodegener. 2012 Mar 16;7:8. doi: 10.1186/1750-1326-7-8.

8.

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA.

Brain. 2011 Jan;134(Pt 1):258-77. doi: 10.1093/brain/awq341.

9.

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease.

Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira J, Tabira T.

FASEB J. 2005 Feb;19(2):255-7. Epub 2004 Nov 17.

10.
11.

Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease.

Moon M, Hong HS, Nam DW, Baik SH, Song H, Kook SY, Kim YS, Lee J, Mook-Jung I.

J Alzheimers Dis. 2012;29(3):615-28. doi: 10.3233/JAD-2011-111778.

PMID:
22269161
12.

High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.

Capetillo-Zarate E, Gracia L, Yu F, Banfelder JR, Lin MT, Tampellini D, Gouras GK.

Am J Pathol. 2011 Nov;179(5):2551-8. doi: 10.1016/j.ajpath.2011.07.045. Epub 2011 Sep 15.

13.

Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.

Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC.

Am J Pathol. 2015 Feb;185(2):305-13. doi: 10.1016/j.ajpath.2014.10.011. Epub 2014 Nov 26.

PMID:
25433221
14.

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R.

J Neurosci. 2006 Oct 4;26(40):10129-40.

15.

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.

Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A.

Acta Neuropathol. 2012 Jan;123(1):53-70. doi: 10.1007/s00401-011-0896-x. Epub 2011 Oct 22.

16.

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.

Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C.

Brain. 2015 Jun;138(Pt 6):1722-37. doi: 10.1093/brain/awv024. Epub 2015 Mar 1.

17.

The inside-out amyloid hypothesis and synapse pathology in Alzheimer's disease.

Gouras GK, Willén K, Faideau M.

Neurodegener Dis. 2014;13(2-3):142-6. doi: 10.1159/000354776. Epub 2013 Sep 24. Review.

PMID:
24080821
18.

Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.

Tampellini D, Rahman N, Lin MT, Capetillo-Zarate E, Gouras GK.

J Neurosci. 2011 Oct 26;31(43):15384-90. doi: 10.1523/JNEUROSCI.2986-11.2011.

19.

Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease.

Richardson JC, Kendal CE, Anderson R, Priest F, Gower E, Soden P, Gray R, Topps S, Howlett DR, Lavender D, Clarke NJ, Barnes JC, Haworth R, Stewart MG, Rupniak HT.

Neuroscience. 2003;122(1):213-28.

PMID:
14596862
20.

Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease.

Zhang YH, Raymick J, Sarkar S, Lahiri DK, Ray B, Holtzman D, Dumas M, Schmued LC.

Curr Alzheimer Res. 2013 Jun;10(5):494-506.

PMID:
23627708
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