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Results: 1 to 20 of 209

1.
2.

Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.

Pearce RE, Uetrecht JP, Leeder JS.

Drug Metab Dispos. 2005 Dec;33(12):1819-26. Epub 2005 Aug 31.

PMID:
16135660
[PubMed - indexed for MEDLINE]
Free Article
3.

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes.

Turpeinen M, Hofmann U, Klein K, Mürdter T, Schwab M, Zanger UM.

Drug Metab Dispos. 2009 May;37(5):1017-24. doi: 10.1124/dmd.108.025700. Epub 2009 Feb 9.

PMID:
19204080
[PubMed - indexed for MEDLINE]
Free Article
4.

Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor.

Tang C, Shou M, Mei Q, Rushmore TH, Rodrigues AD.

J Pharmacol Exp Ther. 2000 May;293(2):453-9.

PMID:
10773015
[PubMed - indexed for MEDLINE]
Free Article
5.

Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies.

Desta Z, Soukhova N, Mahal SK, Flockhart DA.

Drug Metab Dispos. 2000 Jul;28(7):789-800.

PMID:
10859153
[PubMed - indexed for MEDLINE]
Free Article
6.

Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.

Patten CJ, Smith TJ, Murphy SE, Wang MH, Lee J, Tynes RE, Koch P, Yang CS.

Arch Biochem Biophys. 1996 Sep 1;333(1):127-38.

PMID:
8806763
[PubMed - indexed for MEDLINE]
7.

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.

Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS.

Drug Metab Dispos. 2008 Aug;36(8):1637-49. doi: 10.1124/dmd.107.019562. Epub 2008 May 7.

PMID:
18463198
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

Marill J, Cresteil T, Lanotte M, Chabot GG.

Mol Pharmacol. 2000 Dec;58(6):1341-8.

PMID:
11093772
[PubMed - indexed for MEDLINE]
Free Article
9.

Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.

Chang SY, Li W, Traeger SC, Wang B, Cui D, Zhang H, Wen B, Rodrigues AD.

Drug Metab Dispos. 2008 Dec;36(12):2513-22. doi: 10.1124/dmd.108.022970. Epub 2008 Sep 11.

PMID:
18787056
[PubMed - indexed for MEDLINE]
Free Article
10.

Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.

Teiber JF, Hollenberg PF.

Carcinogenesis. 2000 Aug;21(8):1559-66.

PMID:
10910959
[PubMed - indexed for MEDLINE]
Free Article
11.

In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide.

Usmani KA, Rose RL, Goldstein JA, Taylor WG, Brimfield AA, Hodgson E.

Drug Metab Dispos. 2002 Mar;30(3):289-94.

PMID:
11854147
[PubMed - indexed for MEDLINE]
Free Article
12.

O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

Relling MV, Nemec J, Schuetz EG, Schuetz JD, Gonzalez FJ, Korzekwa KR.

Mol Pharmacol. 1994 Feb;45(2):352-8. Erratum in: Mol Pharmacol 1995 Sep;48(3):568.

PMID:
8114683
[PubMed - indexed for MEDLINE]
13.

Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.

Patten CJ, Smith TJ, Friesen MJ, Tynes RE, Yang CS, Murphy SE.

Carcinogenesis. 1997 Aug;18(8):1623-30.

PMID:
9276639
[PubMed - indexed for MEDLINE]
Free Article
14.

Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes.

Nakashima A, Kawashita H, Masuda N, Saxer C, Niina M, Nagae Y, Iwasaki K.

Xenobiotica. 2005 Jun;35(6):589-602.

PMID:
16192110
[PubMed - indexed for MEDLINE]
15.

Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes.

Kim KA, Chung J, Jung DH, Park JY.

Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8.

PMID:
15365656
[PubMed - indexed for MEDLINE]
16.

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

Projean D, Baune B, Farinotti R, Flinois JP, Beaune P, Taburet AM, Ducharme J.

Drug Metab Dispos. 2003 Jun;31(6):748-54.

PMID:
12756207
[PubMed - indexed for MEDLINE]
Free Article
17.

Evidence for the involvement of human liver microsomes CYP1A2 in the mono-hydroxylation of daidzein.

Peng WX, Wang LS, Li HD, Abd El-Aty AM, Chen GL, Zhou HH.

Clin Chim Acta. 2003 Aug;334(1-2):77-85.

PMID:
12867277
[PubMed - indexed for MEDLINE]
18.

Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.

Zerilli A, Ratanasavanh D, Lucas D, Goasduff T, Dréano Y, Menard C, Picart D, Berthou F.

Chem Res Toxicol. 1997 Oct;10(10):1205-12.

PMID:
9348445
[PubMed - indexed for MEDLINE]
19.

Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028.

Kim H, Yoon YJ, Kim H, Kang S, Cheon HG, Yoo SE, Shin JG, Liu KH.

Toxicol Lett. 2006 Oct 10;166(2):105-14. Epub 2006 Jun 12.

PMID:
16857327
[PubMed - indexed for MEDLINE]
20.

Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.

Pearce RE, Gotschall RR, Kearns GL, Leeder JS.

Drug Metab Dispos. 2001 Dec;29(12):1548-54.

PMID:
11717173
[PubMed - indexed for MEDLINE]
Free Article
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