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Items: 1 to 20 of 95

1.

Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon.

Hodge CW, Raber J, McMahon T, Walter H, Sanchez-Perez AM, Olive MF, Mehmert K, Morrow AL, Messing RO.

J Clin Invest. 2002 Oct;110(7):1003-10.

2.

Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon.

Hodge CW, Mehmert KK, Kelley SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM, Messing RO.

Nat Neurosci. 1999 Nov;2(11):997-1002.

PMID:
10526339
3.

Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice.

Proctor WR, Poelchen W, Bowers BJ, Wehner JM, Messing RO, Dunwiddie TV.

J Pharmacol Exp Ther. 2003 Apr;305(1):264-70.

4.

Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice.

Choi DS, Wang D, Dadgar J, Chang WS, Messing RO.

J Neurosci. 2002 Nov 15;22(22):9905-11.

5.

Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior.

Lesscher HM, McMahon T, Lasek AW, Chou WH, Connolly J, Kharazia V, Messing RO.

Genes Brain Behav. 2008 Apr;7(3):323-33. Epub 2007 Oct 1.

6.

Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-epsilon.

Olive MF, Mehmert KK, Nannini MA, Camarini R, Messing RO, Hodge CW.

Neuroscience. 2001;103(1):171-9.

PMID:
11311798
7.

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.

Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO.

J Biol Chem. 2007 Nov 9;282(45):33052-63. Epub 2007 Sep 17.

8.

Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats.

Hirani K, Sharma AN, Jain NS, Ugale RR, Chopde CT.

Psychopharmacology (Berl). 2005 Jul;180(2):267-78. Epub 2005 Feb 18.

PMID:
15719223
9.

Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors.

Harris RA, McQuilkin SJ, Paylor R, Abeliovich A, Tonegawa S, Wehner JM.

Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3658-62.

10.

Control of hormonal stress reactivity by the endogenous opioid system.

Bilkei-Gorzo A, Racz I, Michel K, Mauer D, Zimmer A, Klingmüller D, Zimmer A.

Psychoneuroendocrinology. 2008 May;33(4):425-36. doi: 10.1016/j.psyneuen.2007.12.010. Epub 2008 Feb 15.

PMID:
18280051
11.

Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCgamma null mutant mice.

Bowers BJ, Elliott KJ, Wehner JM.

Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):99-110.

PMID:
11420074
12.
13.

Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor.

Okuyama S, Sakagawa T, Chaki S, Imagawa Y, Ichiki T, Inagami T.

Brain Res. 1999 Mar 6;821(1):150-9.

PMID:
10064799
14.

Testosterone rapidly reduces anxiety in male house mice (Mus musculus).

Aikey JL, Nyby JG, Anmuth DM, James PJ.

Horm Behav. 2002 Dec;42(4):448-60.

PMID:
12488111
15.

K+ channel TASK-1 knockout mice show enhanced sensitivities to ataxic and hypnotic effects of GABA(A) receptor ligands.

Linden AM, Aller MI, Leppä E, Rosenberg PH, Wisden W, Korpi ER.

J Pharmacol Exp Ther. 2008 Oct;327(1):277-86. doi: 10.1124/jpet.108.142083. Epub 2008 Jul 25.

16.

Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.

Singh A, Kumar A.

Methods Find Exp Clin Pharmacol. 2008 Nov;30(9):681-9. doi: 10.1358/mf.2008.30.9.1186076.

PMID:
19229376
17.

The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism.

Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH, Messing RO.

Mol Pharmacol. 2005 Feb;67(2):349-55. Epub 2004 Nov 17.

18.

Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice.

Kita A, Furukawa K.

Pharmacol Biochem Behav. 2008 Apr;89(2):171-8. doi: 10.1016/j.pbb.2007.12.006. Epub 2007 Dec 14.

PMID:
18201755
19.

Anxiolytic drug targets: beyond the usual suspects.

Gordon JA.

J Clin Invest. 2002 Oct;110(7):915-7. No abstract available.

20.

Pharmacogenetic analysis of mechanisms of emotional stress: effects of benzodiazepines.

Seredenin SB, Blednov YuA, Badyshtov BA, Gordey ML, Nagovitsina YA.

Ann Ist Super Sanita. 1990;26(1):81-7.

PMID:
1975488
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