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Results: 1 to 20 of 127

1.

The channel hypothesis of Alzheimer's disease: current status.

Kagan BL, Hirakura Y, Azimov R, Azimova R, Lin MC.

Peptides. 2002 Jul;23(7):1311-5. Review.

PMID:
12128087
[PubMed - indexed for MEDLINE]
2.

Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red.

Hirakura Y, Lin MC, Kagan BL.

J Neurosci Res. 1999 Aug 15;57(4):458-66. Erratum in: J Neurosci Res 1999 Dec 1;58(5):726.

PMID:
10440895
[PubMed - indexed for MEDLINE]
3.

Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review.

Butterfield DA.

Free Radic Res. 2002 Dec;36(12):1307-13. Review.

PMID:
12607822
[PubMed - indexed for MEDLINE]
4.

beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease.

Arispe N, Pollard HB, Rojas E.

Mol Cell Biochem. 1994 Nov 23;140(2):119-25. Review.

PMID:
7898484
[PubMed - indexed for MEDLINE]
5.

Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity.

Pollard HB, Arispe N, Rojas E.

Cell Mol Neurobiol. 1995 Oct;15(5):513-26. Review.

PMID:
8719038
[PubMed - indexed for MEDLINE]
6.

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6538-43. doi: 10.1073/pnas.0914251107. Epub 2010 Mar 22.

PMID:
20308552
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide.

Mirzabekov T, Lin MC, Yuan WL, Marshall PJ, Carman M, Tomaselli K, Lieberburg I, Kagan BL.

Biochem Biophys Res Commun. 1994 Jul 29;202(2):1142-8.

PMID:
7519420
[PubMed - indexed for MEDLINE]
8.

Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block).

Hirakura Y, Yiu WW, Yamamoto A, Kagan BL.

Amyloid. 2000 Sep;7(3):194-9.

PMID:
11019860
[PubMed - indexed for MEDLINE]
9.

Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity.

Díaz JC, Linnehan J, Pollard H, Arispe N.

Biol Res. 2006;39(3):447-60. Epub 2006 Nov 7.

PMID:
17106577
[PubMed - indexed for MEDLINE]
Free Article
10.

Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis.

Kawahara M, Kuroda Y.

Brain Res Bull. 2000 Nov 1;53(4):389-97. Review.

PMID:
11136994
[PubMed - indexed for MEDLINE]
11.

Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers.

Arispe N, Diaz JC, Simakova O.

Biochim Biophys Acta. 2007 Aug;1768(8):1952-65. Epub 2007 Mar 24. Review.

PMID:
17490607
[PubMed - indexed for MEDLINE]
Free Article
12.

Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease.

Blanchard BJ, Konopka G, Russell M, Ingram VM.

Brain Res. 1997 Nov 21;776(1-2):40-50.

PMID:
9439794
[PubMed - indexed for MEDLINE]
13.

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

Arispe N, Rojas E, Pollard HB.

Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):567-71.

PMID:
8380642
[PubMed - indexed for MEDLINE]
Free PMC Article
14.
15.

Ion channel formation by Alzheimer's disease amyloid beta-peptide (Abeta40) in unilamellar liposomes is determined by anionic phospholipids.

Alarcón JM, Brito JA, Hermosilla T, Atwater I, Mears D, Rojas E.

Peptides. 2006 Jan;27(1):95-104. Epub 2005 Sep 1.

PMID:
16139931
[PubMed - indexed for MEDLINE]
16.

Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid.

Nimmrich V, Ebert U.

Rev Neurosci. 2009;20(1):1-12. Review.

PMID:
19526730
[PubMed - indexed for MEDLINE]
17.

A slowly formed transient conformer of Abeta(1-40) is toxic to inward channels of dissociated hippocampal and cortical neurons of rats.

Sun XD, Mo ZL, Taylor BM, Epps DE.

Neurobiol Dis. 2003 Dec;14(3):567-78.

PMID:
14678772
[PubMed - indexed for MEDLINE]
18.

Formation of toxic fibrils of Alzheimer's amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component.

Okada T, Wakabayashi M, Ikeda K, Matsuzaki K.

J Mol Biol. 2007 Aug 10;371(2):481-9. Epub 2007 May 31.

PMID:
17582434
[PubMed - indexed for MEDLINE]
19.

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

Arispe N, Pollard HB, Rojas E.

Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10573-7.

PMID:
7504270
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Heterogeneous amyloid-formed ion channels as a common cytotoxic mechanism: implications for therapeutic strategies against amyloidosis.

Kourie JI, Culverson AL, Farrelly PV, Henry CL, Laohachai KN.

Cell Biochem Biophys. 2002;36(2-3):191-207. Review.

PMID:
12139405
[PubMed - indexed for MEDLINE]

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