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Results: 1 to 20 of 461

1.

An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.

Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL.

Diabetologia. 2002 May;45(5):657-67. Epub 2002 Apr 5.

PMID:
12107746
[PubMed - indexed for MEDLINE]
2.

Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.

Chen D, Van Horn DJ, White MF, Backer JM.

Mol Cell Biol. 1995 Sep;15(9):4711-7.

PMID:
7651388
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.

Ando A, Momomura K, Tobe K, Yamamoto-Honda R, Sakura H, Tamori Y, Kaburagi Y, Koshio O, Akanuma Y, Yazaki Y, et al.

J Biol Chem. 1992 Jun 25;267(18):12788-96.

PMID:
1618780
[PubMed - indexed for MEDLINE]
Free Article
4.

Substitution of glutamine for arginine 1131. A newly identified mutation in the catalytic loop of the tyrosine kinase domain of the human insulin receptor.

Kishimoto M, Hashiramoto M, Yonezawa K, Shii K, Kazumi T, Kasuga M.

J Biol Chem. 1994 Apr 15;269(15):11349-55.

PMID:
7512563
[PubMed - indexed for MEDLINE]
Free Article
5.

Recombinant human alpha 2-HS glycoprotein inhibits insulin-stimulated mitogenic pathway without affecting metabolic signalling in Chinese hamster ovary cells overexpressing the human insulin receptor.

Srinivas PR, Deutsch DD, Mathews ST, Goustin AS, Leon MA, Grunberger G.

Cell Signal. 1996 Dec;8(8):567-73.

PMID:
9115849
[PubMed - indexed for MEDLINE]
7.

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

Yonezawa K, Ando A, Kaburagi Y, Yamamoto-Honda R, Kitamura T, Hara K, Nakafuku M, Okabayashi Y, Kadowaki T, Kaziro Y, et al.

J Biol Chem. 1994 Feb 11;269(6):4634-40.

PMID:
7508445
[PubMed - indexed for MEDLINE]
Free Article
8.

Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.

Krook A, Whitehead JP, Dobson SP, Griffiths MR, Ouwens M, Baker C, Hayward AC, Sen SK, Maassen JA, Siddle K, Tavaré JM, O'Rahilly S.

J Biol Chem. 1997 Nov 28;272(48):30208-14.

PMID:
9374504
[PubMed - indexed for MEDLINE]
Free Article
9.

Differential phosphorylation of IRS-1 by insulin and insulin-like growth factor I receptors in Chinese hamster ovary cells.

Amoui M, Craddock BP, Miller WT.

J Endocrinol. 2001 Oct;171(1):153-62.

PMID:
11572799
[PubMed - indexed for MEDLINE]
Free Article
10.

Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling.

Yoshimura R, Araki E, Ura S, Todaka M, Tsuruzoe K, Furukawa N, Motoshima H, Yoshizato K, Kaneko K, Matsuda K, Kishikawa H, Shichiri M.

Diabetes. 1997 Jun;46(6):929-36.

PMID:
9166661
[PubMed - indexed for MEDLINE]
11.

A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.

Almind K, Inoue G, Pedersen O, Kahn CR.

J Clin Invest. 1996 Jun 1;97(11):2569-75.

PMID:
8647950
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The extracellular portion of the insulin receptor beta-subunit regulates the cellular trafficking of the insulin-insulin receptor complex. Studies on Chinese hamster ovary cells carrying the Cys 860-->Ser insulin receptor mutation.

Benzi L, Cecchetti P, Ciccarone AM, Novelli S, Paoli A, Bertacca A, Maffei M, Maggi D, Andraghetti G, Del Prato S, Cordera R.

Eur J Endocrinol. 2003 Mar;148(3):365-71.

PMID:
12611619
[PubMed - indexed for MEDLINE]
Free Article
13.

N-linked oligosaccharide chains of the insulin receptor beta subunit are essential for transmembrane signaling.

Leconte I, Auzan C, Debant A, Rossi B, Clauser E.

J Biol Chem. 1992 Aug 25;267(24):17415-23.

PMID:
1324936
[PubMed - indexed for MEDLINE]
Free Article
15.

Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.

Pandey NR, Vardatsikos G, Mehdi MZ, Srivastava AK.

J Biol Inorg Chem. 2010 Mar;15(3):399-407. doi: 10.1007/s00775-009-0612-7. Epub 2009 Nov 28.

PMID:
19946718
[PubMed - indexed for MEDLINE]
16.

Severe resistance to insulin and insulin-like growth factor-I in cells from a patient with leprechaunism as a result of two mutations in the tyrosine kinase domain of the insulin receptor.

Desbois-Mouthon C, Danan C, Amselem S, Blivet-Van Eggelpoel MJ, Sert-Langeron C, Goossens M, Besmond C, Capeau J, Caron M.

Metabolism. 1996 Dec;45(12):1493-500.

PMID:
8969282
[PubMed - indexed for MEDLINE]
17.

Cysteine 981 of the human insulin receptor is required for covalent cross-linking between beta-subunit and a thiol-reactive membrane-associated protein.

Garant MJ, Maksimova E, Montrose-Rafizadeh C, Lee-Kwon W, Kole S, Bernier M.

Biochemistry. 2000 Jun 20;39(24):7178-87.

PMID:
10852716
[PubMed - indexed for MEDLINE]
18.

Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor.

Miele C, Caruso M, Calleja V, Auricchio R, Oriente F, Formisano P, Condorelli G, Cafieri A, Sawka-Verhelle D, Van Obberghen E, Beguinot F.

J Biol Chem. 1999 Jan 29;274(5):3094-102.

PMID:
9915848
[PubMed - indexed for MEDLINE]
Free Article
19.

Insulin signals to prenyltransferases via the Shc branch of intracellular signaling.

Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B.

J Biol Chem. 2001 Apr 20;276(16):12805-12. Epub 2001 Jan 25.

PMID:
11278505
[PubMed - indexed for MEDLINE]
Free Article

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