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Items: 1 to 20 of 170

1.

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.

Wyttenbach A, Sauvageot O, Carmichael J, Diaz-Latoud C, Arrigo AP, Rubinsztein DC.

Hum Mol Genet. 2002 May 1;11(9):1137-51.

2.

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation.

Carmichael J, Sugars KL, Bao YP, Rubinsztein DC.

J Biol Chem. 2002 Sep 13;277(37):33791-8. Epub 2002 Jul 3.

3.

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation.

Zhou H, Li SH, Li XJ.

J Biol Chem. 2001 Dec 21;276(51):48417-24. Epub 2001 Oct 17.

5.

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Ravikumar B, Duden R, Rubinsztein DC.

Hum Mol Genet. 2002 May 1;11(9):1107-17.

6.

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins.

Reijonen S, Putkonen N, Nørremølle A, Lindholm D, Korhonen L.

Exp Cell Res. 2008 Mar 10;314(5):950-60. doi: 10.1016/j.yexcr.2007.12.025. Epub 2008 Jan 14.

PMID:
18255062
7.

Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion.

Wu ZL, O'Kane TM, Scott RW, Savage MJ, Bozyczko-Coyne D.

J Biol Chem. 2002 Nov 15;277(46):44208-13. Epub 2002 Sep 10.

8.

Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, Jana NR.

Biochem Biophys Res Commun. 2006 Mar 31;342(1):184-90. Epub 2006 Feb 3.

PMID:
16472774
10.

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE.

J Biol Chem. 2003 Oct 17;278(42):41452-61. Epub 2003 Jul 29.

11.

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

Kim M, Lee HS, LaForet G, McIntyre C, Martin EJ, Chang P, Kim TW, Williams M, Reddy PH, Tagle D, Boyce FM, Won L, Heller A, Aronin N, DiFiglia M.

J Neurosci. 1999 Feb 1;19(3):964-73.

12.

Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease.

Lecerf JM, Shirley TL, Zhu Q, Kazantsev A, Amersdorfer P, Housman DE, Messer A, Huston JS.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4764-9.

14.

Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.

Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S.

J Neurosci. 2008 Aug 27;28(35):8747-55. doi: 10.1523/JNEUROSCI.0973-08.2008.

15.

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.

Wyttenbach A, Swartz J, Kita H, Thykjaer T, Carmichael J, Bradley J, Brown R, Maxwell M, Schapira A, Orntoft TF, Kato K, Rubinsztein DC.

Hum Mol Genet. 2001 Aug 15;10(17):1829-45.

16.

Unraveling a role for dopamine in Huntington's disease: the dual role of reactive oxygen species and D2 receptor stimulation.

Charvin D, Vanhoutte P, Pagès C, Borrelli E, Caboche J.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12218-23. Epub 2005 Aug 15. Erratum in: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16530. Borelli, Emiliana [Borrelli, Emilliana].

17.

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis.

Li SH, Lam S, Cheng AL, Li XJ.

Hum Mol Genet. 2000 Nov 22;9(19):2859-67.

18.

Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model.

Wang W, Duan W, Igarashi S, Morita H, Nakamura M, Ross CA.

Neurobiol Dis. 2005 Nov;20(2):500-8.

PMID:
15908226
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