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Results: 1 to 20 of 181

1.

A Ca(2+) switch aligns the active site of calpain.

Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL.

Cell. 2002 Mar 8;108(5):649-60.

PMID:
11893336
[PubMed - indexed for MEDLINE]
Free Article
2.

Calpain activation by cooperative Ca2+ binding at two non-EF-hand sites.

Moldoveanu T, Jia Z, Davies PL.

J Biol Chem. 2004 Feb 13;279(7):6106-14. Epub 2003 Oct 27.

PMID:
14581465
[PubMed - indexed for MEDLINE]
Free Article
3.

Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.

Jia J, Han Q, Borregaard N, Lollike K, Cygler M.

J Mol Biol. 2000 Jul 28;300(5):1271-81.

PMID:
10903868
[PubMed - indexed for MEDLINE]
4.

Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes.

Blanchard H, Grochulski P, Li Y, Arthur JS, Davies PL, Elce JS, Cygler M.

Nat Struct Biol. 1997 Jul;4(7):532-8.

PMID:
9228945
[PubMed - indexed for MEDLINE]
5.

Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography.

Cuerrier D, Moldoveanu T, Inoue J, Davies PL, Campbell RL.

Biochemistry. 2006 Jun 20;45(24):7446-52.

PMID:
16768440
[PubMed - indexed for MEDLINE]
6.

Calpain silencing by a reversible intrinsic mechanism.

Moldoveanu T, Hosfield CM, Lim D, Jia Z, Davies PL.

Nat Struct Biol. 2003 May;10(5):371-8.

PMID:
12665854
[PubMed - indexed for MEDLINE]
7.

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin.

Hanna RA, Campbell RL, Davies PL.

Nature. 2008 Nov 20;456(7220):409-12. doi: 10.1038/nature07451.

PMID:
19020623
[PubMed - indexed for MEDLINE]
8.

Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation.

Hosfield CM, Elce JS, Davies PL, Jia Z.

EMBO J. 1999 Dec 15;18(24):6880-9.

PMID:
10601010
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain.

Hosfield CM, Moldoveanu T, Davies PL, Elce JS, Jia Z.

J Biol Chem. 2001 Mar 9;276(10):7404-7. Epub 2000 Dec 1.

PMID:
11102442
[PubMed - indexed for MEDLINE]
Free Article
10.

Domain II of m-calpain is a Ca(2+)-dependent cysteine protease.

Hata S, Sorimachi H, Nakagawa K, Maeda T, Abe K, Suzuki K.

FEBS Lett. 2001 Jul 20;501(2-3):111-4.

PMID:
11470267
[PubMed - indexed for MEDLINE]
Free Article
11.

Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.

Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS.

Biochem J. 2002 Oct 1;367(Pt 1):263-9.

PMID:
12014988
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.

Moldoveanu T, Campbell RL, Cuerrier D, Davies PL.

J Mol Biol. 2004 Nov 5;343(5):1313-26.

PMID:
15491615
[PubMed - indexed for MEDLINE]
13.

Structural basis for possible calcium-induced activation mechanisms of calpains.

Reverter D, Strobl S, Fernandez-Catalan C, Sorimachi H, Suzuki K, Bode W.

Biol Chem. 2001 May;382(5):753-66.

PMID:
11517928
[PubMed - indexed for MEDLINE]
14.

Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease?

Melloni E, Averna M, Stifanese R, De Tullio R, Defranchi E, Salamino F, Pontremoli S.

J Biol Chem. 2006 Aug 25;281(34):24945-54. Epub 2006 Jun 27.

PMID:
16803906
[PubMed - indexed for MEDLINE]
Free Article
15.

Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.

Moldoveanu T, Gehring K, Green DR.

Nature. 2008 Nov 20;456(7220):404-8. doi: 10.1038/nature07353.

PMID:
19020622
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Roles of individual EF-hands in the activation of m-calpain by calcium.

Dutt P, Arthur JS, Grochulski P, Cygler M, Elce JS.

Biochem J. 2000 May 15;348 Pt 1:37-43.

PMID:
10794711
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor.

Todd B, Moore D, Deivanayagam CC, Lin GD, Chattopadhyay D, Maki M, Wang KK, Narayana SV.

J Mol Biol. 2003 Apr 18;328(1):131-46.

PMID:
12684003
[PubMed - indexed for MEDLINE]
18.

Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease.

Vaisid T, Kosower NS, Katzav A, Chapman J, Barnoy S.

Neurochem Int. 2007 Nov-Dec;51(6-7):391-7. Epub 2007 Apr 19.

PMID:
17513017
[PubMed - indexed for MEDLINE]
19.

Distinguishing between calpain heterodimerization and homodimerization.

Ravulapalli R, Campbell RL, Gauthier SY, Dhe-Paganon S, Davies PL.

FEBS J. 2009 Feb;276(4):973-82. doi: 10.1111/j.1742-4658.2008.06833.x.

PMID:
19215300
[PubMed - indexed for MEDLINE]
20.

Dissociation and aggregation of calpain in the presence of calcium.

Pal GP, Elce JS, Jia Z.

J Biol Chem. 2001 Dec 14;276(50):47233-8. Epub 2001 Sep 10.

PMID:
11551918
[PubMed - indexed for MEDLINE]
Free Article

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