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Similar articles for PubMed (Select 11889123)


Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.

Karmakar P, Piotrowski J, Brosh RM Jr, Sommers JA, Miller SP, Cheng WH, Snowden CM, Ramsden DA, Bohr VA.

J Biol Chem. 2002 May 24;277(21):18291-302. Epub 2002 Mar 11.


Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.

Yannone SM, Roy S, Chan DW, Murphy MB, Huang S, Campisi J, Chen DJ.

J Biol Chem. 2001 Oct 12;276(41):38242-8. Epub 2001 Jul 27.


Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.

Opresko PL, Laine JP, Brosh RM Jr, Seidman MM, Bohr VA.

J Biol Chem. 2001 Nov 30;276(48):44677-87. Epub 2001 Sep 25.


Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex.

Li B, Comai L.

J Biol Chem. 2001 Mar 30;276(13):9896-902. Epub 2001 Jan 4.


Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.

Li B, Comai L.

Nucleic Acids Res. 2002 Sep 1;30(17):3653-61.


Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.

Cheng WH, von Kobbe C, Opresko PL, Fields KM, Ren J, Kufe D, Bohr VA.

Mol Cell Biol. 2003 Sep;23(18):6385-95.


Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.

Karmakar P, Snowden CM, Ramsden DA, Bohr VA.

Nucleic Acids Res. 2002 Aug 15;30(16):3583-91.


Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing.

Kusumoto R, Dawut L, Marchetti C, Wan Lee J, Vindigni A, Ramsden D, Bohr VA.

Biochemistry. 2008 Jul 15;47(28):7548-56. doi: 10.1021/bi702325t. Epub 2008 Jun 18.


Enzymatic mechanism of the WRN helicase/nuclease.

Brosh RM Jr, Opresko PL, Bohr VA.

Methods Enzymol. 2006;409:52-85.


Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.

Friedemann J, Grosse F, Zhang S.

J Biol Chem. 2005 Sep 2;280(35):31303-13. Epub 2005 Jul 1.


DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA.

Machwe A, Xiao L, Theodore S, Orren DK.

J Biol Chem. 2002 Feb 8;277(6):4492-504. Epub 2001 Nov 20.


Werner syndrome protein: biochemical properties and functional interactions.

Bohr VA, Cooper M, Orren D, Machwe A, Piotrowski J, Sommers J, Karmakar P, Brosh R.

Exp Gerontol. 2000 Sep;35(6-7):695-702. Review.


A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.

Orren DK, Machwe A, Karmakar P, Piotrowski J, Cooper MP, Bohr VA.

Nucleic Acids Res. 2001 May 1;29(9):1926-34.


Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.

Choudhary S, Sommers JA, Brosh RM Jr.

J Biol Chem. 2004 Aug 13;279(33):34603-13. Epub 2004 Jun 8.


Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions.

Harrigan JA, Piotrowski J, Di Noto L, Levine RL, Bohr VA.

J Biol Chem. 2007 Dec 14;282(50):36403-11. Epub 2007 Oct 2.


Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

Shen JC, Gray MD, Oshima J, Kamath-Loeb AS, Fry M, Loeb LA.

J Biol Chem. 1998 Dec 18;273(51):34139-44.


The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.

Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP.

Biochemistry. 2002 Oct 22;41(42):12706-14.


Protein phosphatases regulate DNA-dependent protein kinase activity.

Douglas P, Moorhead GB, Ye R, Lees-Miller SP.

J Biol Chem. 2001 Jun 1;276(22):18992-8. Epub 2001 Mar 16.


p53 Modulates the exonuclease activity of Werner syndrome protein.

Brosh RM Jr, Karmakar P, Sommers JA, Yang Q, Wang XW, Spillare EA, Harris CC, Bohr VA.

J Biol Chem. 2001 Sep 14;276(37):35093-102. Epub 2001 Jun 26.


DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer.

Chan DW, Ye R, Veillette CJ, Lees-Miller SP.

Biochemistry. 1999 Feb 9;38(6):1819-28.

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