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Results: 1 to 20 of 155

1.

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

Basso AD, Solit DB, Munster PN, Rosen N.

Oncogene. 2002 Feb 14;21(8):1159-66.

PMID:
11850835
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.

Srethapakdi M, Liu F, Tavorath R, Rosen N.

Cancer Res. 2000 Jul 15;60(14):3940-6.

PMID:
10919672
[PubMed - indexed for MEDLINE]
Free Article
4.

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

Solit DB, Zheng FF, Drobnjak M, Münster PN, Higgins B, Verbel D, Heller G, Tong W, Cordon-Cardo C, Agus DB, Scher HI, Rosen N.

Clin Cancer Res. 2002 May;8(5):986-93.

PMID:
12006510
[PubMed - indexed for MEDLINE]
Free Article
5.

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.

Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N.

Cancer Res. 2003 May 1;63(9):2139-44.

PMID:
12727831
[PubMed - indexed for MEDLINE]
Free Article
6.
7.

Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.

Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL.

Cancer Res. 2002 Jul 15;62(14):4132-41.

PMID:
12124352
[PubMed - indexed for MEDLINE]
Free Article
8.

Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells.

Münster PN, Srethapakdi M, Moasser MM, Rosen N.

Cancer Res. 2001 Apr 1;61(7):2945-52.

PMID:
11306472
[PubMed - indexed for MEDLINE]
Free Article
9.
10.

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

Knuefermann C, Lu Y, Liu B, Jin W, Liang K, Wu L, Schmidt M, Mills GB, Mendelsohn J, Fan Z.

Oncogene. 2003 May 22;22(21):3205-12.

PMID:
12761490
[PubMed - indexed for MEDLINE]
11.

The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.

Xu W, Yuan X, Jung YJ, Yang Y, Basso A, Rosen N, Chung EJ, Trepel J, Neckers L.

Cancer Res. 2003 Nov 15;63(22):7777-84.

PMID:
14633703
[PubMed - indexed for MEDLINE]
Free Article
12.
13.

Enhancement of the p27Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells.

Marches R, Uhr JW.

Int J Cancer. 2004 Nov 10;112(3):492-501.

PMID:
15382077
[PubMed - indexed for MEDLINE]
14.

BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells.

Banerji L, Glassford J, Lea NC, Thomas NS, Klaus GG, Lam EW.

Oncogene. 2001 Nov 1;20(50):7352-67.

PMID:
11704865
[PubMed - indexed for MEDLINE]
Free Article
15.

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M.

Clin Cancer Res. 2004 Dec 1;10(23):8059-67.

PMID:
15585641
[PubMed - indexed for MEDLINE]
Free Article
16.

(-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells.

Shimizu M, Deguchi A, Lim JT, Moriwaki H, Kopelovich L, Weinstein IB.

Clin Cancer Res. 2005 Apr 1;11(7):2735-46.

PMID:
15814656
[PubMed - indexed for MEDLINE]
Free Article
17.

Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.

Nencioni A, Cea M, Garuti A, Passalacqua M, Raffaghello L, Soncini D, Moran E, Zoppoli G, Pistoia V, Patrone F, Ballestrero A.

PLoS One. 2010 Feb 2;5(2):e9024. doi: 10.1371/journal.pone.0009024.

PMID:
20126311
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.

Premkumar DR, Arnold B, Jane EP, Pollack IF.

Mol Carcinog. 2006 Jan;45(1):47-59.

PMID:
16267832
[PubMed - indexed for MEDLINE]
19.
20.

Cyclin D3 is down-regulated by rapamycin in HER-2-overexpressing breast cancer cells.

García-Morales P, Hernando E, Carrasco-García E, Menéndez-Gutierrez MP, Saceda M, Martínez-Lacaci I.

Mol Cancer Ther. 2006 Sep;5(9):2172-81.

PMID:
16985050
[PubMed - indexed for MEDLINE]
Free Article

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