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Results: 1 to 20 of 108

1.

High-density miniaturized thermal shift assays as a general strategy for drug discovery.

Pantoliano MW, Petrella EC, Kwasnoski JD, Lobanov VS, Myslik J, Graf E, Carver T, Asel E, Springer BA, Lane P, Salemme FR.

J Biomol Screen. 2001 Dec;6(6):429-40.

PMID:
11788061
[PubMed - indexed for MEDLINE]
2.

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery.

Lo MC, Aulabaugh A, Jin G, Cowling R, Bard J, Malamas M, Ellestad G.

Anal Biochem. 2004 Sep 1;332(1):153-9.

PMID:
15301960
[PubMed - indexed for MEDLINE]
3.

Novel trends in high-throughput screening.

Mayr LM, Bojanic D.

Curr Opin Pharmacol. 2009 Oct;9(5):580-8. doi: 10.1016/j.coph.2009.08.004. Epub 2009 Sep 21. Review.

PMID:
19775937
[PubMed - indexed for MEDLINE]
5.

Screening for ligands using a generic and high-throughput light-scattering-based assay.

Senisterra GA, Markin E, Yamazaki K, Hui R, Vedadi M, Awrey DE.

J Biomol Screen. 2006 Dec;11(8):940-8. Epub 2006 Nov 7.

PMID:
17092916
[PubMed - indexed for MEDLINE]
6.

Quantitative determination of protein stability and ligand binding using a green fluorescent protein reporter system.

Moreau MJ, Morin I, Schaeffer PM.

Mol Biosyst. 2010 Jul;6(7):1285-92. doi: 10.1039/c002001j. Epub 2010 May 7.

PMID:
20454718
[PubMed - indexed for MEDLINE]
7.

NMR-based screening methods for lead discovery.

Vogtherr M, Fiebig K.

EXS. 2003;(93):183-202. Review.

PMID:
12613177
[PubMed - indexed for MEDLINE]
8.

Emerging techniques for the discovery and validation of therapeutic targets for skeletal diseases.

Cho CH, Nuttall ME.

Expert Opin Ther Targets. 2002 Dec;6(6):679-89. Review.

PMID:
12472380
[PubMed - indexed for MEDLINE]
9.

High throughput screening methodologies classified for major drug target classes according to target signaling pathways.

Kool J, Lingeman H, Niessen W, Irth H.

Comb Chem High Throughput Screen. 2010 Jul;13(6):548-61. Review.

PMID:
20429869
[PubMed - indexed for MEDLINE]
10.

A dual estrogen receptor TR-FRET assay for simultaneous measurement of steroid site binding and coactivator recruitment.

Hilal T, Puetter V, Otto C, Parczyk K, Bader B.

J Biomol Screen. 2010 Mar;15(3):268-78. doi: 10.1177/1087057109359196. Epub 2010 Feb 11.

PMID:
20150592
[PubMed - indexed for MEDLINE]
11.

Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader.

Hodder P, Mull R, Cassaday J, Berry K, Strulovici B.

J Biomol Screen. 2004 Aug;9(5):417-26.

PMID:
15296641
[PubMed - indexed for MEDLINE]
12.

ID NMR Methods in ligand-receptor interactions.

Zartler ER, Yan J, Mo H, Kline AD, Shapiro MJ.

Curr Top Med Chem. 2003;3(1):25-37. Review.

PMID:
12577989
[PubMed - indexed for MEDLINE]
13.

Recent advances of fluorescent technologies for drug discovery and development.

Chakraborty C, Hsu CH, Wen ZH, Lin CS.

Curr Pharm Des. 2009;15(30):3552-70. Review.

PMID:
19860700
[PubMed - indexed for MEDLINE]
14.

Fluorescence polarization is a useful technology for reagent reduction in assay miniaturization.

Kowski TJ, Wu JJ.

Comb Chem High Throughput Screen. 2000 Oct;3(5):437-44.

PMID:
11032959
[PubMed - indexed for MEDLINE]
15.

Virtual screening and its integration with modern drug design technologies.

Guido RV, Oliva G, Andricopulo AD.

Curr Med Chem. 2008;15(1):37-46. Review.

PMID:
18220761
[PubMed - indexed for MEDLINE]
16.

Use of fluorescence polarization detection for the measurement of fluopeptidetm binding to G protein-coupled receptors.

Gagne A, Banks P, Hurt SD.

J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):333-43.

PMID:
12503625
[PubMed - indexed for MEDLINE]
17.

Compound profiling using a panel of steroid hormone receptor cell-based assays.

Wilkinson JM, Hayes S, Thompson D, Whitney P, Bi K.

J Biomol Screen. 2008 Sep;13(8):755-65. doi: 10.1177/1087057108322155. Epub 2008 Aug 27.

PMID:
18753690
[PubMed - indexed for MEDLINE]
18.

Development of multiplexed microarray binding assays for high-throughput drug discovery.

Hong Y, Liu L, Pai S, Graf JN, Rao H, Lynn JG, van Staden C, Lee PH, Lai F, Salon JA.

Assay Drug Dev Technol. 2009 Jun;7(3):281-93. doi: 10.1089/adt.2008.180.

PMID:
19604106
[PubMed - indexed for MEDLINE]
19.

Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes.

Layton CJ, Hellinga HW.

Biochemistry. 2010 Dec 28;49(51):10831-41. doi: 10.1021/bi101414z. Epub 2010 Dec 3.

PMID:
21050007
[PubMed - indexed for MEDLINE]
20.

New assay technologies for high-throughput screening.

Silverman L, Campbell R, Broach JR.

Curr Opin Chem Biol. 1998 Jun;2(3):397-403. Review.

PMID:
9691081
[PubMed - indexed for MEDLINE]

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