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Results: 1 to 20 of 155

1.

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.

Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC.

Nat Cell Biol. 2001 Nov;3(11):973-82. Erratum in: Nat Cell Biol 2002 Sep;4(9):736.

PMID:
11715018
[PubMed - indexed for MEDLINE]
2.

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y.

J Biol Chem. 2002 Jun 14;277(24):21843-50. Epub 2002 Mar 28.

PMID:
11923280
[PubMed - indexed for MEDLINE]
Free Article
3.

HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage.

Pääjärvi G, Roudier E, Crisby M, Högberg J, Stenius U.

FASEB J. 2005 Mar;19(3):476-8. Epub 2004 Dec 29.

PMID:
15625077
[PubMed - indexed for MEDLINE]
Free Article
4.

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.

Feng J, Tamaskovic R, Yang Z, Brazil DP, Merlo A, Hess D, Hemmings BA.

J Biol Chem. 2004 Aug 20;279(34):35510-7. Epub 2004 May 28.

PMID:
15169778
[PubMed - indexed for MEDLINE]
Free Article
5.

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

Wang W, Takimoto R, Rastinejad F, El-Deiry WS.

Mol Cell Biol. 2003 Mar;23(6):2171-81.

PMID:
12612087
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

Honda R, Yasuda H.

EMBO J. 1999 Jan 4;18(1):22-7.

PMID:
9878046
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.

Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC.

Nat Cell Biol. 2001 Mar;3(3):245-52.

PMID:
11231573
[PubMed - indexed for MEDLINE]
8.

Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis.

Zhu Q, Yao J, Wani G, Wani MA, Wani AA.

J Biol Chem. 2001 Aug 10;276(32):29695-701. Epub 2001 May 4.

PMID:
11340074
[PubMed - indexed for MEDLINE]
Free Article
9.

MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation.

Jin Y, Zeng SX, Lee H, Lu H.

J Biol Chem. 2004 May 7;279(19):20035-43. Epub 2004 Feb 9.

PMID:
14769800
[PubMed - indexed for MEDLINE]
Free Article
10.

STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis.

Townsend PA, Scarabelli TM, Davidson SM, Knight RA, Latchman DS, Stephanou A.

J Biol Chem. 2004 Feb 13;279(7):5811-20. Epub 2003 Nov 5.

PMID:
14602726
[PubMed - indexed for MEDLINE]
Free Article
11.

PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells.

Zhou M, Gu L, Findley HW, Jiang R, Woods WG.

Cancer Res. 2003 Oct 1;63(19):6357-62.

PMID:
14559824
[PubMed - indexed for MEDLINE]
Free Article
12.

Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells.

Jeong SJ, Pise-Masison CA, Radonovich MF, Park HU, Brady JN.

Oncogene. 2005 Oct 6;24(44):6719-28.

PMID:
16007163
[PubMed - indexed for MEDLINE]
13.

Mdm2 association with p53 targets its ubiquitination.

Fuchs SY, Adler V, Buschmann T, Wu X, Ronai Z.

Oncogene. 1998 Nov 12;17(19):2543-7.

PMID:
9824166
[PubMed - indexed for MEDLINE]
Free Article
14.

p300/MDM2 complexes participate in MDM2-mediated p53 degradation.

Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM.

Mol Cell. 1998 Oct;2(4):405-15.

PMID:
9809062
[PubMed - indexed for MEDLINE]
Free Article
15.

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.

Mayo LD, Donner DB.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11598-603. Epub 2001 Aug 14.

PMID:
11504915
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

Grossman SR, Deato ME, Brignone C, Chan HM, Kung AL, Tagami H, Nakatani Y, Livingston DM.

Science. 2003 Apr 11;300(5617):342-4.

PMID:
12690203
[PubMed - indexed for MEDLINE]
Free Article
17.

ARF function does not require p53 stabilization or Mdm2 relocalization.

Korgaonkar C, Zhao L, Modestou M, Quelle DE.

Mol Cell Biol. 2002 Jan;22(1):196-206.

PMID:
11739734
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ, Sonenshein GE.

Oncogene. 2001 Mar 15;20(11):1287-99.

PMID:
11313873
[PubMed - indexed for MEDLINE]
Free Article
19.
20.

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo.

Midgley CA, Desterro JM, Saville MK, Howard S, Sparks A, Hay RT, Lane DP.

Oncogene. 2000 May 4;19(19):2312-23.

PMID:
10822382
[PubMed - indexed for MEDLINE]
Free Article

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