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Results: 1 to 20 of 482

1.

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance.

Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C.

Circulation. 2001 Nov 6;104(19):2338-43.

PMID:
11696475
[PubMed - indexed for MEDLINE]
Free Article
2.

Contribution of phosphodiesterase isoenzymes and cyclic nucleotide efflux to the regulation of cyclic GMP levels in aortic smooth muscle cells.

Mercapide J, Santiago E, Alberdi E, Martinez-Irujo JJ.

Biochem Pharmacol. 1999 Nov 15;58(10):1675-83.

PMID:
10535760
[PubMed - indexed for MEDLINE]
3.

The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord.

de Vente J, Markerink-van Ittersum M, Vles JS.

J Chem Neuroanat. 2006 Jun;31(4):275-303. Epub 2006 Apr 18.

PMID:
16621445
[PubMed - indexed for MEDLINE]
4.

Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta.

Mülsch A, Oelze M, Klöss S, Mollnau H, Töpfer A, Smolenski A, Walter U, Stasch JP, Warnholtz A, Hink U, Meinertz T, Münzel T.

Circulation. 2001 May 1;103(17):2188-94.

PMID:
11331261
[PubMed - indexed for MEDLINE]
Free Article
5.

Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling.

Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C.

J Mol Cell Cardiol. 2005 Jan;38(1):175-84. Epub 2004 Dec 8.

PMID:
15623434
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation.

MacPherson JD, Gillespie TD, Dunkerley HA, Maurice DH, Bennett BM.

J Pharmacol Exp Ther. 2006 Apr;317(1):188-95. Epub 2005 Dec 5.

PMID:
16330494
[PubMed - indexed for MEDLINE]
Free Article
7.

Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells.

Papapetropoulos A, Go CY, Murad F, Catravas JD.

Br J Pharmacol. 1996 Jan;117(1):147-55.

PMID:
8825356
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Cardiovascular effects of a novel, potent and selective phosphodiesterase 5 inhibitor, DMPPO: in vitro and in vivo characterization.

Delpy E, le Monnier de Gouville AC.

Br J Pharmacol. 1996 Jul;118(6):1377-84.

PMID:
8832060
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Role of cyclic AMP- and cyclic GMP-phosphodiesterases in the control of cyclic nucleotide levels and smooth muscle tone in rat isolated aorta. A study with selective inhibitors.

Schoeffter P, Lugnier C, Demesy-Waeldele F, Stoclet JC.

Biochem Pharmacol. 1987 Nov 15;36(22):3965-72.

PMID:
2825708
[PubMed - indexed for MEDLINE]
10.

Changes in phosphodiesterase activity in the developing rat submandibular gland.

Tanaka S, Shimooka S, Shimomura H.

Arch Oral Biol. 2002 Aug;47(8):567-76.

PMID:
12221013
[PubMed - indexed for MEDLINE]
11.

Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle.

Gerzanich V, Ivanov A, Ivanova S, Yang JB, Zhou H, Dong Y, Simard JM.

Circ Res. 2003 Oct 31;93(9):805-12. Epub 2003 Sep 25.

PMID:
14512447
[PubMed - indexed for MEDLINE]
Free Article
12.

Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor.

Liu CQ, Leung FP, Lee VW, Lau CW, Yao X, Lu L, Huang Y.

Eur J Pharmacol. 2008 Aug 20;590(1-3):250-4. doi: 10.1016/j.ejphar.2008.05.009. Epub 2008 May 20.

PMID:
18554583
[PubMed - indexed for MEDLINE]
13.

Cyclic GMP potentiation by WIN 58237, a novel cyclic nucleotide phosphodiesterase inhibitor.

Silver PJ, Dundore RL, Bode DC, de Garavilla L, Buchholz RA, van Aller G, Hamel LT, Bacon E, Singh B, Lesher GY, et al.

J Pharmacol Exp Ther. 1994 Dec;271(3):1143-9.

PMID:
7996419
[PubMed - indexed for MEDLINE]
14.

Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages.

Witwicka H, Kobiałka M, Siednienko J, Mitkiewicz M, Gorczyca WA.

Biochim Biophys Acta. 2007 Feb;1773(2):209-18. Epub 2006 Oct 24.

PMID:
17141339
[PubMed - indexed for MEDLINE]
Free Article
15.

Angiotensin AT2 receptor mediated inhibition of particulate guanylate cyclase: a link with protein tyrosine phosphatase stimulation?

Brechler V, Levens NR, De Gasparo M, Bottari SP.

Receptors Channels. 1994;2(2):79-87.

PMID:
7525002
[PubMed - indexed for MEDLINE]
16.

Desensitization of NO/cGMP signaling in smooth muscle: blood vessels versus airways.

Mullershausen F, Lange A, Mergia E, Friebe A, Koesling D.

Mol Pharmacol. 2006 Jun;69(6):1969-74. Epub 2006 Mar 1.

PMID:
16510560
[PubMed - indexed for MEDLINE]
Free Article
17.

Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes.

Geng Y, Zhou L, Thompson WJ, Lotz M.

J Biol Chem. 1998 Oct 16;273(42):27484-91.

PMID:
9765278
[PubMed - indexed for MEDLINE]
Free Article
18.

Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells.

Zhu B, Strada S, Stevens T.

Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L196-206. Epub 2005 Mar 25.

PMID:
15792963
[PubMed - indexed for MEDLINE]
Free Article
19.

Reversal of nitroglycerin tolerance in vitro by the cGMP-phosphodiesterase inhibitor zaprinast.

Pagani ED, VanAller GS, O'Connor B, Silver PJ.

Eur J Pharmacol. 1993 Oct 19;243(2):141-7.

PMID:
8276063
[PubMed - indexed for MEDLINE]
20.

"cAMP-specific" phosphodiesterase contributes to cGMP degradation in cerebellar cells exposed to nitric oxide.

Bellamy TC, Garthwaite J.

Mol Pharmacol. 2001 Jan;59(1):54-61.

PMID:
11125024
[PubMed - indexed for MEDLINE]
Free Article
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