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Results: 1 to 20 of 184

1.

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.

Hegde R, Srinivasula SM, Zhang Z, Wassell R, Mukattash R, Cilenti L, DuBois G, Lazebnik Y, Zervos AS, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 2002 Jan 4;277(1):432-8. Epub 2001 Oct 17.

PMID:
11606597
[PubMed - indexed for MEDLINE]
Free Article
2.

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.

Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downward J.

J Biol Chem. 2002 Jan 4;277(1):439-44. Epub 2001 Oct 15.

PMID:
11602612
[PubMed - indexed for MEDLINE]
Free Article
3.

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL.

J Biol Chem. 2002 Jan 4;277(1):445-54. Epub 2001 Oct 16.

PMID:
11604410
[PubMed - indexed for MEDLINE]
Free Article
4.

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.

Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R.

Cell Death Differ. 2004 Feb;11(2):208-16.

PMID:
14605674
[PubMed - indexed for MEDLINE]
Free Article
5.

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.

Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R.

Mol Cell. 2001 Sep;8(3):613-21.

PMID:
11583623
[PubMed - indexed for MEDLINE]
Free Article
6.

Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein.

Fu J, Jin Y, Arend LJ.

J Biol Chem. 2003 Dec 26;278(52):52660-72. Epub 2003 Sep 30.

PMID:
14523016
[PubMed - indexed for MEDLINE]
Free Article
7.

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.

Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES.

Nature. 2001 Mar 1;410(6824):112-6. Erratum in: Nature 2001 Jun 28;411(6841):1081.

PMID:
11242052
[PubMed - indexed for MEDLINE]
8.

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.

Yang QH, Church-Hajduk R, Ren J, Newton ML, Du C.

Genes Dev. 2003 Jun 15;17(12):1487-96.

PMID:
12815069
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

van Loo G, van Gurp M, Depuydt B, Srinivasula SM, Rodriguez I, Alnemri ES, Gevaert K, Vandekerckhove J, Declercq W, Vandenabeele P.

Cell Death Differ. 2002 Jan;9(1):20-6.

PMID:
11803371
[PubMed - indexed for MEDLINE]
Free Article
10.

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.

Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 2003 Aug 22;278(34):31469-72. Epub 2003 Jun 30.

PMID:
12835328
[PubMed - indexed for MEDLINE]
Free Article
11.

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.

Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y.

Nat Struct Biol. 2002 Jun;9(6):436-41.

PMID:
11967569
[PubMed - indexed for MEDLINE]
12.

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brandner S, Schulz JB, Mak T, Downward J.

Mol Cell Biol. 2004 Nov;24(22):9848-62.

PMID:
15509788
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP.

Seong YM, Choi JY, Park HJ, Kim KJ, Ahn SG, Seong GH, Kim IK, Kang S, Rhim H.

J Biol Chem. 2004 Sep 3;279(36):37588-96. Epub 2004 Jun 16.

PMID:
15201285
[PubMed - indexed for MEDLINE]
Free Article
14.

Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.

Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K.

J Biol Chem. 2004 May 7;279(19):19665-82. Epub 2004 Mar 1.

PMID:
14993223
[PubMed - indexed for MEDLINE]
Free Article
15.

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.

Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB.

EMBO J. 2007 Jul 11;26(13):3144-56. Epub 2007 Jun 7.

PMID:
17557079
[PubMed - indexed for MEDLINE]
Free PMC Article
16.
17.

Endogenously released Smac is insufficient to mediate cell death of human lung carcinoma in response to etoposide.

Bartling B, Lewensohn R, Zhivotovsky B.

Exp Cell Res. 2004 Aug 1;298(1):83-95.

PMID:
15242764
[PubMed - indexed for MEDLINE]
18.

Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.

Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL.

Circulation. 2005 Jan 4;111(1):90-6. Epub 2004 Dec 20.

PMID:
15611365
[PubMed - indexed for MEDLINE]
Free Article
19.

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs.

Verhagen AM, Kratina TK, Hawkins CJ, Silke J, Ekert PG, Vaux DL.

Cell Death Differ. 2007 Feb;14(2):348-57. Epub 2006 Jun 23.

PMID:
16794601
[PubMed - indexed for MEDLINE]
Free Article
20.

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.

Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J.

J Biol Chem. 2003 Dec 5;278(49):49417-27. Epub 2003 Sep 25.

PMID:
14512424
[PubMed - indexed for MEDLINE]
Free Article

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