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Results: 1 to 20 of 235

1.

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.

Polyak SJ, Khabar KS, Paschal DM, Ezelle HJ, Duverlie G, Barber GN, Levy DE, Mukaida N, Gretch DR.

J Virol. 2001 Jul;75(13):6095-106.

PMID:
11390611
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase.

Gale M Jr, Kwieciszewski B, Dossett M, Nakao H, Katze MG.

J Virol. 1999 Aug;73(8):6506-16.

PMID:
10400746
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance.

Gale MJ Jr, Korth MJ, Katze MG.

Clin Diagn Virol. 1998 Jul 15;10(2-3):157-62. Review.

PMID:
9741641
[PubMed - indexed for MEDLINE]
4.

Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication.

Polyak SJ, Paschal DM, McArdle S, Gale MJ Jr, Moradpour D, Gretch DR.

Hepatology. 1999 Apr;29(4):1262-71.

PMID:
10094974
[PubMed - indexed for MEDLINE]
5.

Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells.

Plumlee CR, Lazaro CA, Fausto N, Polyak SJ.

Virol J. 2005 Dec 2;2:89.

PMID:
16324217
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein.

Gale MJ Jr, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, Polyak SJ, Gretch DR, Katze MG.

Virology. 1997 Apr 14;230(2):217-27.

PMID:
9143277
[PubMed - indexed for MEDLINE]
Free Article
7.

Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis.

Fran├žois C, Duverlie G, Rebouillat D, Khorsi H, Castelain S, Blum HE, Gatignol A, Wychowski C, Moradpour D, Meurs EF.

J Virol. 2000 Jun;74(12):5587-96.

PMID:
10823866
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.

He Y, Tan SL, Tareen SU, Vijaysri S, Langland JO, Jacobs BL, Katze MG.

J Virol. 2001 Jun;75(11):5090-8.

PMID:
11333890
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Hepatitis C virus non-structural 5A abrogates signal transducer and activator of transcription-1 nuclear translocation induced by IFN-alpha through dephosphorylation.

Gong GZ, Cao J, Jiang YF, Zhou Y, Liu B.

World J Gastroenterol. 2007 Aug 14;13(30):4080-4.

PMID:
17696225
[PubMed - indexed for MEDLINE]
Free Article
10.

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.

Gale M Jr, Blakely CM, Kwieciszewski B, Tan SL, Dossett M, Tang NM, Korth MJ, Polyak SJ, Gretch DR, Katze MG.

Mol Cell Biol. 1998 Sep;18(9):5208-18.

PMID:
9710605
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The nonstructural NS5A protein of hepatitis C virus: an expanding, multifunctional role in enhancing hepatitis C virus pathogenesis.

Reyes GR.

J Biomed Sci. 2002 May-Jun;9(3):187-97. Review.

PMID:
12065893
[PubMed - indexed for MEDLINE]
12.

Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells.

Noguchi T, Satoh S, Noshi T, Hatada E, Fukuda R, Kawai A, Ikeda S, Hijikata M, Shimotohno K.

Microbiol Immunol. 2001;45(12):829-40. Erratum in: Microbiol Immunol. 2002;46(4):305.

PMID:
11838900
[PubMed - indexed for MEDLINE]
13.

HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines.

Lan KH, Lan KL, Lee WP, Sheu ML, Chen MY, Lee YL, Yen SH, Chang FY, Lee SD.

J Hepatol. 2007 May;46(5):759-67. Epub 2006 Dec 14.

PMID:
17275127
[PubMed - indexed for MEDLINE]
14.

Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.

Geiss GK, Carter VS, He Y, Kwieciszewski BK, Holzman T, Korth MJ, Lazaro CA, Fausto N, Bumgarner RE, Katze MG.

J Virol. 2003 Jun;77(11):6367-75.

PMID:
12743294
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon.

Song J, Fujii M, Wang F, Itoh M, Hotta H.

J Gen Virol. 1999 Apr;80 ( Pt 4):879-86.

PMID:
10211956
[PubMed - indexed for MEDLINE]
Free Article
16.

Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein.

Fukuma T, Enomoto N, Marumo F, Sato C.

Hepatology. 1998 Oct;28(4):1147-53.

PMID:
9755255
[PubMed - indexed for MEDLINE]
17.

The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism.

Tsai YH, Kuang WF, Lu TY, Kao JH, Lai MY, Liu CJ, Chen PJ, Hwang LH.

J Hepatol. 2008 Dec;49(6):899-907. doi: 10.1016/j.jhep.2008.06.030. Epub 2008 Sep 16.

PMID:
18842320
[PubMed - indexed for MEDLINE]
18.

Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations.

Pawlotsky JM, Germanidis G, Neumann AU, Pellerin M, Frainais PO, Dhumeaux D.

J Virol. 1998 Apr;72(4):2795-805.

PMID:
9525599
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Nonstructural proteins 4A and 4B of hepatitis C virus transactivate the interleukin 8 promoter.

Kadoya H, Nagano-Fujii M, Deng L, Nakazono N, Hotta H.

Microbiol Immunol. 2005;49(3):265-73.

PMID:
15782000
[PubMed - indexed for MEDLINE]
20.

Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy.

Nousbaum J, Polyak SJ, Ray SC, Sullivan DG, Larson AM, Carithers RL Jr, Gretch DR.

J Virol. 2000 Oct;74(19):9028-38.

PMID:
10982347
[PubMed - indexed for MEDLINE]
Free PMC Article

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