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Items: 1 to 20 of 104

1.

New metabolic pathways of alpha-lipoic acid.

Schupke H, Hempel R, Peter G, Hermann R, Wessel K, Engel J, Kronbach T.

Drug Metab Dispos. 2001 Jun;29(6):855-62.

2.

Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.

Mamidi RN, Mannens G, Annaert P, Hendrickx J, Goris I, Bockx M, Janssen CG, Kao M, Kelley MF, Meuldermans W.

Drug Metab Dispos. 2007 Apr;35(4):566-75. Epub 2007 Jan 12.

3.

Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers.

Teichert J, Hermann R, Ruus P, Preiss R.

J Clin Pharmacol. 2003 Nov;43(11):1257-67.

PMID:
14551180
4.

In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

Lang D, Freudenberger C, Weinz C.

Drug Metab Dispos. 2009 May;37(5):1046-55. doi: 10.1124/dmd.108.025551. Epub 2009 Feb 5.

5.

Metabolism and excretion of loratadine in male and female mice, rats and monkeys.

Ramanathan R, Alvarez N, Su AD, Chowdhury S, Alton K, Stauber K, Patrick J.

Xenobiotica. 2005 Feb;35(2):155-89.

PMID:
16019945
6.

Biotransformation of nevirapine, a non-nucleoside HIV-1 reverse transcriptase inhibitor, in mice, rats, rabbits, dogs, monkeys, and chimpanzees.

Riska PS, Joseph DP, Dinallo RM, Davidson WC, Keirns JJ, Hattox SE.

Drug Metab Dispos. 1999 Dec;27(12):1434-47.

7.

Metabolism, distribution and excretion of a selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in rats and dogs.

Prakash C, Cui D, Potchoiba MJ, Butler T.

Drug Metab Dispos. 2007 Aug;35(8):1350-64. Epub 2007 May 11.

8.

Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans.

Weinz C, Schwarz T, Kubitza D, Mueck W, Lang D.

Drug Metab Dispos. 2009 May;37(5):1056-64. doi: 10.1124/dmd.108.025569. Epub 2009 Feb 5.

9.
10.

In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.

Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P.

Drug Metab Dispos. 2006 Feb;34(2):213-24. Epub 2005 Oct 28.

11.

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.

Zhang D, Raghavan N, Chen SY, Zhang H, Quan M, Lecureux L, Patrone LM, Lam PY, Bonacorsi SJ, Knabb RM, Skiles GL, He K.

Drug Metab Dispos. 2008 Feb;36(2):303-15. Epub 2007 Nov 5.

12.

Metabolism of vabicaserin in mice, rats, dogs, monkeys, and humans.

Tong Z, Chandrasekaran A, DeMaio W, Espina R, Lu W, Jordan R, Scatina J.

Drug Metab Dispos. 2010 Dec;38(12):2266-77. doi: 10.1124/dmd.110.033670. Epub 2010 Aug 25.

14.

Investigation of the drug-drug interaction between alpha-lipoic acid and valproate via mitochondrial beta-oxidation.

Phua LC, New LS, Goh CW, Neo AH, Browne ER, Chan EC.

Pharm Res. 2008 Nov;25(11):2639-49. doi: 10.1007/s11095-008-9681-5. Epub 2008 Jul 18.

PMID:
18636319
15.

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG.

Drug Metab Dispos. 2007 Jan;35(1):150-67. Epub 2006 Oct 24.

18.

Distribution study of orally administered lipoic acid in rat brain tissues.

Chng HT, New LS, Neo AH, Goh CW, Browne ER, Chan EC.

Brain Res. 2009 Jan 28;1251:80-6. doi: 10.1016/j.brainres.2008.11.025. Epub 2008 Nov 19.

PMID:
19046949
19.

Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites.

Li W, Zhang D, Wang L, Zhang H, Cheng PT, Zhang D, Everett DW, Humphreys WG.

Drug Metab Dispos. 2006 May;34(5):807-20. Epub 2006 Feb 7.

20.

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH.

Drug Metab Dispos. 2004 Feb;32(2):246-58.

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