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Results: 1 to 20 of 126

1.

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).

Guermonprez P, Khelef N, Blouin E, Rieu P, Ricciardi-Castagnoli P, Guiso N, Ladant D, Leclerc C.

J Exp Med. 2001 May 7;193(9):1035-44.

PMID:
11342588
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain.

El-Azami-El-Idrissi M, Bauche C, Loucka J, Osicka R, Sebo P, Ladant D, Leclerc C.

J Biol Chem. 2003 Oct 3;278(40):38514-21. Epub 2003 Jul 28.

PMID:
12885782
[PubMed - indexed for MEDLINE]
Free Article
3.

Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis.

Eby JC, Gray MC, Mangan AR, Donato GM, Hewlett EL.

Infect Immun. 2012 Feb;80(2):850-9. doi: 10.1128/IAI.05979-11. Epub 2011 Dec 5.

PMID:
22144488
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes.

Basler M, Masin J, Osicka R, Sebo P.

Infect Immun. 2006 Apr;74(4):2207-14.

PMID:
16552051
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities.

Fiser R, Masín J, Basler M, Krusek J, Spuláková V, Konopásek I, Sebo P.

J Biol Chem. 2007 Feb 2;282(5):2808-20. Epub 2006 Dec 4.

PMID:
17148436
[PubMed - indexed for MEDLINE]
Free Article
6.

Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two steps.

Bumba L, Masin J, Fiser R, Sebo P.

PLoS Pathog. 2010 May 13;6(5):e1000901. doi: 10.1371/journal.ppat.1000901.

PMID:
20485565
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Ca2+ influx and tyrosine kinases trigger Bordetella adenylate cyclase toxin (ACT) endocytosis. Cell physiology and expression of the CD11b/CD18 integrin major determinants of the entry route.

Uribe KB, Martín C, Etxebarria A, González-Bullón D, Gómez-Bilbao G, Ostolaza H.

PLoS One. 2013 Sep 13;8(9):e74248. doi: 10.1371/journal.pone.0074248. eCollection 2013.

PMID:
24058533
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death.

Boyd AP, Ross PJ, Conroy H, Mahon N, Lavelle EC, Mills KH.

J Immunol. 2005 Jul 15;175(2):730-8.

PMID:
16002668
[PubMed - indexed for MEDLINE]
Free Article
9.

Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling.

Kamanova J, Kofronova O, Masin J, Genth H, Vojtova J, Linhartova I, Benada O, Just I, Sebo P.

J Immunol. 2008 Oct 15;181(8):5587-97.

PMID:
18832717
[PubMed - indexed for MEDLINE]
Free Article
10.

RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides.

Morova J, Osicka R, Masin J, Sebo P.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5355-60. doi: 10.1073/pnas.0711400105. Epub 2008 Mar 28.

PMID:
18375764
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Evaluation of adenyl cyclase toxin constructs from Bordetella pertussis as candidate vaccine components in an in vitro model of complement-dependent intraphagocytic killing.

Prior S, Fleck RA, Gillett ML, Rigsby PR, Corbel MJ, Stacey GN, Xing DK.

Vaccine. 2006 May 29;24(22):4794-803. Epub 2006 Apr 3.

PMID:
16675078
[PubMed - indexed for MEDLINE]
12.

Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis.

Gray MC, Donato GM, Jones FR, Kim T, Hewlett EL.

Mol Microbiol. 2004 Sep;53(6):1709-19.

PMID:
15341649
[PubMed - indexed for MEDLINE]
13.

Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells.

Masin J, Basler M, Knapp O, El-Azami-El-Idrissi M, Maier E, Konopasek I, Benz R, Leclerc C, Sebo P.

Biochemistry. 2005 Sep 27;44(38):12759-66.

PMID:
16171390
[PubMed - indexed for MEDLINE]
14.

Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells.

Hickey FB, Brereton CF, Mills KH.

J Leukoc Biol. 2008 Jul;84(1):234-43. doi: 10.1189/jlb.0208113. Epub 2008 Apr 9.

PMID:
18401006
[PubMed - indexed for MEDLINE]
Free Article
15.

Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1).

Perkins DJ, Gray MC, Hewlett EL, Vogel SN.

Mol Microbiol. 2007 Nov;66(4):1003-15. Epub 2007 Oct 10.

PMID:
17927697
[PubMed - indexed for MEDLINE]
16.

Characterization of recombinant Bordetella pertussis adenylate cyclase toxins carrying passenger proteins.

Gmira S, Karimova G, Ladant D.

Res Microbiol. 2001 Dec;152(10):889-900.

PMID:
11766964
[PubMed - indexed for MEDLINE]
17.

Essential role of methionine residues in calmodulin binding to Bordetella pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases.

Vougier S, Mary J, Dautin N, Vinh J, Friguet B, Ladant D.

J Biol Chem. 2004 Jul 16;279(29):30210-8. Epub 2004 May 17.

PMID:
15148319
[PubMed - indexed for MEDLINE]
Free Article
18.

Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils.

Mobberley-Schuman PS, Weiss AA.

Infect Immun. 2005 Nov;73(11):7317-23.

PMID:
16239529
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Bordetella adenylate cyclase toxin: a swift saboteur of host defense.

Vojtova J, Kamanova J, Sebo P.

Curr Opin Microbiol. 2006 Feb;9(1):69-75. Epub 2006 Jan 6. Review.

PMID:
16406775
[PubMed - indexed for MEDLINE]

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