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Items: 1 to 20 of 130

1.

A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis.

Ruiz FE, Clancy JP, Perricone MA, Bebok Z, Hong JS, Cheng SH, Meeker DP, Young KR, Schoumacher RA, Weatherly MR, Wing L, Morris JE, Sindel L, Rosenberg M, van Ginkel FW, McGhee JR, Kelly D, Lyrene RK, Sorscher EJ.

Hum Gene Ther. 2001 May 1;12(7):751-61.

PMID:
11339892
2.

Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung.

Scheule RK, St George JA, Bagley RG, Marshall J, Kaplan JM, Akita GY, Wang KX, Lee ER, Harris DJ, Jiang C, Yew NS, Smith AE, Cheng SH.

Hum Gene Ther. 1997 Apr 10;8(6):689-707.

PMID:
9113509
3.

Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. I. Methods, safety, and clinical implications.

Joseph PM, O'Sullivan BP, Lapey A, Dorkin H, Oren J, Balfour R, Perricone MA, Rosenberg M, Wadsworth SC, Smith AE, St George JA, Meeker DP.

Hum Gene Ther. 2001 Jul 20;12(11):1369-82.

PMID:
11485629
4.

Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo.

Zabner J, Cheng SH, Meeker D, Launspach J, Balfour R, Perricone MA, Morris JE, Marshall J, Fasbender A, Smith AE, Welsh MJ.

J Clin Invest. 1997 Sep 15;100(6):1529-37.

5.

Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.

Porteous DJ, Dorin JR, McLachlan G, Davidson-Smith H, Davidson H, Stevenson BJ, Carothers AD, Wallace WA, Moralee S, Hoenes C, Kallmeyer G, Michaelis U, Naujoks K, Ho LP, Samways JM, Imrie M, Greening AP, Innes JA.

Gene Ther. 1997 Mar;4(3):210-8.

6.

A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease.

Aitken ML, Moss RB, Waltz DA, Dovey ME, Tonelli MR, McNamara SC, Gibson RL, Ramsey BW, Carter BJ, Reynolds TC.

Hum Gene Ther. 2001 Oct 10;12(15):1907-16.

PMID:
11589832
7.

Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus.

Wagner JA, Messner AH, Moran ML, Daifuku R, Kouyama K, Desch JK, Manley S, Norbash AM, Conrad CK, Friborg S, Reynolds T, Guggino WB, Moss RB, Carter BJ, Wine JJ, Flotte TR, Gardner P.

Laryngoscope. 1999 Feb;109(2 Pt 1):266-74.

PMID:
10890777
8.

Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.

Hyde SC, Southern KW, Gileadi U, Fitzjohn EM, Mofford KA, Waddell BE, Gooi HC, Goddard CA, Hannavy K, Smyth SE, Egan JJ, Sorgi FL, Huang L, Cuthbert AW, Evans MJ, Colledge WH, Higgins CF, Webb AK, Gill DR.

Gene Ther. 2000 Jul;7(13):1156-65.

9.

Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways.

Rose AC, Goddard CA, Colledge WH, Cheng SH, Gill DR, Hyde SC.

Gene Ther. 2002 Oct;9(19):1312-20.

10.

[Aerosol administration of a replication defective recombinant adenovirus expressing normal human cDNA-CFTR in the respiratory tractus in patients with cystic fibrosis].

Bellon G, Calmard L, Thouvenot D, Levrey H, Jagneaux V, Poitevin F, Malcus C, Accart N, Séné C, Layani MP, Aymard M, Bienvenu J, Courtney M, Döring G, Gilly B, Gilly R, Lamy D, Morel Y, Paulin C, Perraud F, Rodillon L, So S, Touraine F, Schatz C, Pavirani A.

C R Seances Soc Biol Fil. 1996;190(1):109-42. French.

PMID:
8881273
11.

Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium.

Perricone MA, Morris JE, Pavelka K, Plog MS, O'Sullivan BP, Joseph PM, Dorkin H, Lapey A, Balfour R, Meeker DP, Smith AE, Wadsworth SC, St George JA.

Hum Gene Ther. 2001 Jul 20;12(11):1383-94.

PMID:
11485630
12.

Radioisotopic imaging allows optimization of adenovirus lung deposition for cystic fibrosis gene therapy.

Lerondel S, Le Pape A, Sené C, Faure L, Bernard S, Diot P, Nicolis E, Mehtali M, Lusky M, Cabrini G, Pavirani A.

Hum Gene Ther. 2001 Jan 1;12(1):1-11.

PMID:
11177537
13.

Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study.

Flotte TR, Zeitlin PL, Reynolds TC, Heald AE, Pedersen P, Beck S, Conrad CK, Brass-Ernst L, Humphries M, Sullivan K, Wetzel R, Taylor G, Carter BJ, Guggino WB.

Hum Gene Ther. 2003 Jul 20;14(11):1079-88.

PMID:
12885347
14.

Insertion of natural intron 6a-6b into a human cDNA-derived gene therapy vector for cystic fibrosis improves plasmid stability and permits facile RNA/DNA discrimination.

Boyd AC, Popp F, Michaelis U, Davidson H, Davidson-Smith H, Doherty A, McLachlan G, Porteous DJ, Seeber S.

J Gene Med. 1999 Sep-Oct;1(5):312-21.

PMID:
10738548
15.

Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung.

Lee ER, Marshall J, Siegel CS, Jiang C, Yew NS, Nichols MR, Nietupski JB, Ziegler RJ, Lane MB, Wang KX, Wan NC, Scheule RK, Harris DJ, Smith AE, Cheng SH.

Hum Gene Ther. 1996 Sep 10;7(14):1701-17.

PMID:
8886841
16.

Cationic lipid:pDNA complexes for the treatment of cystic fibrosis.

Eastman SJ, Scheule RK.

Curr Opin Mol Ther. 1999 Apr;1(2):186-96. Review.

PMID:
11715942
17.

Technology evaluation: cystic fibrosis therapy, Genzyme.

Cockett MI.

Curr Opin Mol Ther. 1999 Apr;1(2):279-83. Review.

PMID:
11715952
18.

A double-blind, placebo controlled, dose ranging study to evaluate the safety and biological efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with cystic fibrosis.

Knowles MR, Noone PG, Hohneker K, Johnson LG, Boucher RC, Efthimiou J, Crawford C, Brown R, Schwartzbach C, Pearlman R.

Hum Gene Ther. 1998 Jan 20;9(2):249-69.

PMID:
9472784
19.

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.

Caplen NJ, Alton EW, Middleton PG, Dorin JR, Stevenson BJ, Gao X, Durham SR, Jeffery PK, Hodson ME, Coutelle C, et al.

Nat Med. 1995 Jan;1(1):39-46. Erratum in: Nat Med 1995 Mar;1(3):272.

PMID:
7584951
20.

Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung.

Conrad CK, Allen SS, Afione SA, Reynolds TC, Beck SE, Fee-Maki M, Barrazza-Ortiz X, Adams R, Askin FB, Carter BJ, Guggino WB, Flotte TR.

Gene Ther. 1996 Aug;3(8):658-68.

PMID:
8854091
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