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Results: 1 to 20 of 72

1.

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.

Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp-Lorenzino L, Rosen N.

Chem Biol. 2001 Mar;8(3):289-99.

PMID:
11306353
[PubMed - indexed for MEDLINE]
Free Article
2.

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

Schulte TW, Akinaga S, Soga S, Sullivan W, Stensgard B, Toft D, Neckers LM.

Cell Stress Chaperones. 1998 Jun;3(2):100-8.

PMID:
9672245
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ.

Mol Cancer Ther. 2009 Apr;8(4):921-9. doi: 10.1158/1535-7163.MCT-08-0758.

PMID:
19372565
[PubMed - indexed for MEDLINE]
Free Article
4.

Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.

Bagatell R, Khan O, Paine-Murrieta G, Taylor CW, Akinaga S, Whitesell L.

Clin Cancer Res. 2001 Jul;7(7):2076-84.

PMID:
11448926
[PubMed - indexed for MEDLINE]
Free Article
5.

Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells.

Münster PN, Srethapakdi M, Moasser MM, Rosen N.

Cancer Res. 2001 Apr 1;61(7):2945-52.

PMID:
11306472
[PubMed - indexed for MEDLINE]
Free Article
6.

Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes.

Peng X, Guo X, Borkan SC, Bharti A, Kuramochi Y, Calderwood S, Sawyer DB.

J Biol Chem. 2005 Apr 1;280(13):13148-52. Epub 2005 Jan 25.

PMID:
15671027
[PubMed - indexed for MEDLINE]
Free Article
7.

Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents.

Miyata Y.

Curr Pharm Des. 2005;11(9):1131-8. Review.

PMID:
15853661
[PubMed - indexed for MEDLINE]
8.
9.

Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.

Le Brazidec JY, Kamal A, Busch D, Thao L, Zhang L, Timony G, Grecko R, Trent K, Lough R, Salazar T, Khan S, Burrows F, Boehm MF.

J Med Chem. 2004 Jul 15;47(15):3865-73.

PMID:
15239664
[PubMed - indexed for MEDLINE]
10.

Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide.

Clevenger RC, Blagg BS.

Org Lett. 2004 Nov 25;6(24):4459-62.

PMID:
15548050
[PubMed - indexed for MEDLINE]
11.

Stereospecific antitumor activity of radicicol oxime derivatives.

Soga S, Sharma SV, Shiotsu Y, Shimizu M, Tahara H, Yamaguchi K, Ikuina Y, Murakata C, Tamaoki T, Kurebayashi J, Schulte TW, Neckers LM, Akinaga S.

Cancer Chemother Pharmacol. 2001 Dec;48(6):435-45.

PMID:
11800023
[PubMed - indexed for MEDLINE]
12.

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.

Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP.

Cell. 1997 Apr 18;89(2):239-50.

PMID:
9108479
[PubMed - indexed for MEDLINE]
Free Article
13.

Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases.

Zheng FF, Kuduk SD, Chiosis G, Münster PN, Sepp-Lorenzino L, Danishefsky SJ, Rosen N.

Cancer Res. 2000 Apr 15;60(8):2090-4.

PMID:
10786665
[PubMed - indexed for MEDLINE]
Free Article
14.

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.

Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV.

Mol Endocrinol. 1999 Sep;13(9):1435-48.

PMID:
10478836
[PubMed - indexed for MEDLINE]
15.

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification.

Neckers L.

Curr Med Chem. 2003 May;10(9):733-9. Review.

PMID:
12678776
[PubMed - indexed for MEDLINE]
16.

Dimeric ansamycins--a new class of antitumor Hsp90 modulators with prolonged inhibitory activity.

Zhang H, Yang YC, Zhang L, Fan J, Chung D, Choi D, Grecko R, Timony G, Karjian P, Boehm M, Burrows F.

Int J Cancer. 2007 Feb 15;120(4):918-26.

PMID:
17131314
[PubMed - indexed for MEDLINE]
17.

Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.

Chen WY, Chang FR, Huang ZY, Chen JH, Wu YC, Wu CC.

J Biol Chem. 2008 Jun 20;283(25):17184-93. doi: 10.1074/jbc.M709447200. Epub 2008 Apr 28.

PMID:
18442981
[PubMed - indexed for MEDLINE]
Free Article
18.

The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level.

Yu W, Rao Q, Wang M, Tian Z, Lin D, Liu X, Wang J.

Leuk Res. 2006 May;30(5):575-82. Epub 2005 Oct 6.

PMID:
16213582
[PubMed - indexed for MEDLINE]
19.

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aherne W, McDonald E, Workman P.

Cancer Res. 2007 Mar 1;67(5):2206-16.

PMID:
17332351
[PubMed - indexed for MEDLINE]
Free Article
20.

Synthesis of Hsp90 inhibitor dimers as potential antitumor agents.

Muranaka K, Sano A, Ichikawa S, Matsuda A.

Bioorg Med Chem. 2008 Jun 1;16(11):5862-70. doi: 10.1016/j.bmc.2008.04.070. Epub 2008 May 1.

PMID:
18487051
[PubMed - indexed for MEDLINE]

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