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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

Ito A, Lai CH, Zhao X, Saito S, Hamilton MH, Appella E, Yao TP.

EMBO J. 2001 Mar 15;20(6):1331-40.


MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins.

Kobet E, Zeng X, Zhu Y, Keller D, Lu H.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12547-52.


Inhibition of p53 degradation by Mdm2 acetylation.

Wang X, Taplick J, Geva N, Oren M.

FEBS Lett. 2004 Mar 12;561(1-3):195-201.


MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.

Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, Yao TP.

EMBO J. 2002 Nov 15;21(22):6236-45.


MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation.

Jin Y, Zeng SX, Dai MS, Yang XJ, Lu H.

J Biol Chem. 2002 Aug 23;277(34):30838-43. Epub 2002 Jun 14.


Dynamics of the p53 acetylation pathway.

Gu W, Luo J, Brooks CL, Nikolaev AY, Li M.

Novartis Found Symp. 2004;259:197-205; discussion 205-7, 223-5. Review.


MDMX inhibits the p300/CBP-mediated acetylation of p53.

Sabbatini P, McCormick F.

DNA Cell Biol. 2002 Jul;21(7):519-25.


p300/MDM2 complexes participate in MDM2-mediated p53 degradation.

Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM.

Mol Cell. 1998 Oct;2(4):405-15.


YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

Grönroos E, Terentiev AA, Punga T, Ericsson J.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12165-70. Epub 2004 Aug 4.


Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification.

Knights CD, Liu Y, Appella E, Kulesz-Martin M.

J Biol Chem. 2003 Dec 26;278(52):52890-900. Epub 2003 Oct 10.


Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.

Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U, Kundu TK.

J Biol Chem. 2004 Dec 3;279(49):51163-71. Epub 2004 Sep 20.


MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation.

Jin Y, Zeng SX, Lee H, Lu H.

J Biol Chem. 2004 May 7;279(19):20035-43. Epub 2004 Feb 9.


Dual role of p300 in the regulation of p53 stability.

Kawai H, Nie L, Wiederschain D, Yuan ZM.

J Biol Chem. 2001 Dec 7;276(49):45928-32. Epub 2001 Oct 8.


P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.

Tao W, Levine AJ.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6937-41.


Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.

Ard PG, Chatterjee C, Kunjibettu S, Adside LR, Gralinski LE, McMahon SB.

Mol Cell Biol. 2002 Aug;22(16):5650-61.

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