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Results: 1 to 20 of 218

1.

Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.

Reiman EM, Caselli RJ, Chen K, Alexander GE, Bandy D, Frost J.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3334-9.

PMID:
11248079
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D.

N Engl J Med. 1996 Mar 21;334(12):752-8.

PMID:
8592548
[PubMed - indexed for MEDLINE]
Free Article
3.

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.

Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):284-9. Epub 2003 Dec 19.

PMID:
14688411
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies.

Alexander GE, Chen K, Pietrini P, Rapoport SI, Reiman EM.

Am J Psychiatry. 2002 May;159(5):738-45.

PMID:
11986126
[PubMed - indexed for MEDLINE]
5.

Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele.

Langbaum JB, Chen K, Caselli RJ, Lee W, Reschke C, Bandy D, Alexander GE, Burns CM, Kaszniak AW, Reeder SA, Corneveaux JJ, Allen AN, Pruzin J, Huentelman MJ, Fleisher AS, Reiman EM.

Arch Neurol. 2010 Apr;67(4):462-8. doi: 10.1001/archneurol.2010.30.

PMID:
20385913
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Apolipoprotein E polymorphism influences the cerebral metabolic pattern in Alzheimer's disease.

Mielke R, Zerres K, Uhlhaas S, Kessler J, Heiss WD.

Neurosci Lett. 1998 Sep 18;254(1):49-52.

PMID:
9780089
[PubMed - indexed for MEDLINE]
7.

Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.

Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8299-302. Epub 2005 Jun 2.

PMID:
15932949
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Single photon emission computed tomography and apolipoprotein E in Alzheimer's disease: impact of the epsilon4 allele on regional cerebral blood flow.

Høgh P, Knudsen GM, Kjaer KH, Jørgensen OS, Paulson OB, Waldemar G.

J Geriatr Psychiatry Neurol. 2001 Spring;14(1):42-51.

PMID:
11281316
[PubMed - indexed for MEDLINE]
9.

Double-blind crossover study of the cognitive effects of lorazepam in healthy apolipoprotein E (APOE)-epsilon4 carriers.

Stonnington CM, Snyder PJ, Hentz JG, Reiman EM, Caselli RJ.

J Clin Psychiatry. 2009 Oct;70(10):1379-84. doi: 10.4088/JCP.08m04593. Epub 2009 Jun 30.

PMID:
19573495
[PubMed - indexed for MEDLINE]
10.

Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.

Wishart HA, Saykin AJ, Rabin LA, Santulli RB, Flashman LA, Guerin SJ, Mamourian AC, Belloni DR, Rhodes CH, McAllister TW.

Am J Psychiatry. 2006 Sep;163(9):1603-10.

PMID:
16946187
[PubMed - indexed for MEDLINE]
11.

Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.

Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen PJ Sr, Soininen H.

J Neurol Neurosurg Psychiatry. 1998 Sep;65(3):322-7.

PMID:
9728943
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease.

Reiman EM, Uecker A, Caselli RJ, Lewis S, Bandy D, de Leon MJ, De Santi S, Convit A, Osborne D, Weaver A, Thibodeau SN.

Ann Neurol. 1998 Aug;44(2):288-91.

PMID:
9708558
[PubMed - indexed for MEDLINE]
13.

Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers.

Lind J, Persson J, Ingvar M, Larsson A, Cruts M, Van Broeckhoven C, Adolfsson R, Bäckman L, Nilsson LG, Petersson KM, Nyberg L.

Brain. 2006 May;129(Pt 5):1240-8. Epub 2006 Mar 14.

PMID:
16537568
[PubMed - indexed for MEDLINE]
Free Article
14.

Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study.

Mosconi L, Sorbi S, Nacmias B, De Cristofaro MT, Fayyaz M, Bracco L, Herholz K, Pupi A.

Psychiatry Res. 2004 Feb 15;130(2):141-51.

PMID:
15033184
[PubMed - indexed for MEDLINE]
15.

Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study.

Trivedi MA, Schmitz TW, Ries ML, Torgerson BM, Sager MA, Hermann BP, Asthana S, Johnson SC.

BMC Med. 2006 Jan 13;4:1.

PMID:
16412236
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Perceived loss of memory ability and cerebral metabolic decline in persons with the apolipoprotein E-IV genetic risk for Alzheimer disease.

Ercoli L, Siddarth P, Huang SC, Miller K, Bookheimer SY, Wright BC, Phelps ME, Small G.

Arch Gen Psychiatry. 2006 Apr;63(4):442-8.

PMID:
16585474
[PubMed - indexed for MEDLINE]
17.

Cerebral blood flow and metabolic abnormalities in Alzheimer's disease.

Matsuda H.

Ann Nucl Med. 2001 Apr;15(2):85-92. Review.

PMID:
11448080
[PubMed - indexed for MEDLINE]
18.

Linking brain imaging and genomics in the study of Alzheimer's disease and aging.

Reiman EM.

Ann N Y Acad Sci. 2007 Feb;1097:94-113. Review.

PMID:
17413015
[PubMed - indexed for MEDLINE]
19.

Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging.

Reiman EM, Chen K, Langbaum JB, Lee W, Reschke C, Bandy D, Alexander GE, Caselli RJ.

Neuroimage. 2010 Jan 1;49(1):169-76. doi: 10.1016/j.neuroimage.2009.07.025. Epub 2009 Jul 23.

PMID:
19631758
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes.

Caselli RJ, Graff-Radford NR, Reiman EM, Weaver A, Osborne D, Lucas J, Uecker A, Thibodeau SN.

Neurology. 1999 Jul 13;53(1):201-7.

PMID:
10408560
[PubMed - indexed for MEDLINE]

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