Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 155

1.

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.

Kahn CR, Brüning JC, Michael MD, Kulkarni RN.

J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1377-84. Review.

PMID:
11202213
[PubMed - indexed for MEDLINE]
2.
3.

Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function.

Kulkarni RN.

Biochem Soc Trans. 2002 Apr;30(2):317-22. Review.

PMID:
12023872
[PubMed - indexed for MEDLINE]
4.

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

Simmgen M, Knauf C, Lopez M, Choudhury AI, Charalambous M, Cantley J, Bedford DC, Claret M, Iglesias MA, Heffron H, Cani PD, Vidal-Puig A, Burcelin R, Withers DJ.

Diabetologia. 2006 Mar;49(3):552-61. Epub 2006 Jan 11.

PMID:
16404553
[PubMed - indexed for MEDLINE]
5.

Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes?

Sesti G.

Ann Med. 2002;34(6):444-50. Review.

PMID:
12523500
[PubMed - indexed for MEDLINE]
6.

Molecular insights into insulin action and secretion.

Rhodes CJ, White MF.

Eur J Clin Invest. 2002 Jun;32 Suppl 3:3-13. Review.

PMID:
12028370
[PubMed - indexed for MEDLINE]
7.

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ.

Diabetologia. 2007 Jun;50(6):1248-56. Epub 2007 Mar 29.

PMID:
17393136
[PubMed - indexed for MEDLINE]
8.

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

Lingohr MK, Buettner R, Rhodes CJ.

Trends Mol Med. 2002 Aug;8(8):375-84. Review.

PMID:
12127723
[PubMed - indexed for MEDLINE]
9.

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.

Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR.

Cell. 1997 Feb 21;88(4):561-72.

PMID:
9038347
[PubMed - indexed for MEDLINE]
Free Article
10.

A signal for beta-cell failure.

Avruch J.

Nature. 1998 Feb 26;391(6670):846-7. No abstract available.

PMID:
9495335
[PubMed - indexed for MEDLINE]
11.

The insulin receptor--a critical link in glucose homeostasis and insulin action.

Patti ME, Kahn CR.

J Basic Clin Physiol Pharmacol. 1998;9(2-4):89-109. Review.

PMID:
10212828
[PubMed - indexed for MEDLINE]
12.

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.

Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF.

Diabetes. 2004 Jan;53(1):61-6.

PMID:
14693698
[PubMed - indexed for MEDLINE]
Free Article
13.

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes.

Kahn CR.

Exp Diabesity Res. 2003 Jul-Sep;4(3):169-82. Review.

PMID:
15061645
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Diabetes: the importance of the liver.

Rutter GA.

Curr Biol. 2000 Oct 19;10(20):R736-8. Review.

PMID:
11069096
[PubMed - indexed for MEDLINE]
Free Article
15.

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR.

Cell. 1999 Feb 5;96(3):329-39.

PMID:
10025399
[PubMed - indexed for MEDLINE]
Free Article
16.

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.

Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR.

Diabetes. 2003 Jun;52(6):1528-34.

PMID:
12765966
[PubMed - indexed for MEDLINE]
Free Article
17.

Biomedicine. New insights into type 2 diabetes.

Alper J.

Science. 2000 Jul 7;289(5476):37-9.

PMID:
10928926
[PubMed - indexed for MEDLINE]
18.

Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice.

Nakae J, Kido Y, Accili D.

Ann Med. 2001 Feb;33(1):22-7. Review.

PMID:
11310935
[PubMed - indexed for MEDLINE]
19.

Evidence for a circulating islet cell growth factor in insulin-resistant states.

Flier SN, Kulkarni RN, Kahn CR.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7475-80. Epub 2001 Jun 12.

PMID:
11404474
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2.

Kim JJ, Kido Y, Scherer PE, White MF, Accili D.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1694-701. Epub 2007 Feb 13.

PMID:
17299086
[PubMed - indexed for MEDLINE]
Free Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk