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Results: 1 to 20 of 172

1.

The productive conformation of arachidonic acid bound to prostaglandin synthase.

Malkowski MG, Ginell SL, Smith WL, Garavito RM.

Science. 2000 Sep 15;289(5486):1933-7.

PMID:
10988074
[PubMed - indexed for MEDLINE]
Free Article
2.

Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases.

Thuresson ED, Malkowski MG, Lakkides KM, Rieke CJ, Mulichak AM, Ginell SL, Garavito RM, Smith WL.

J Biol Chem. 2001 Mar 30;276(13):10358-65. Epub 2000 Dec 19.

PMID:
11121413
[PubMed - indexed for MEDLINE]
Free Article
3.

Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.

Harman CA, Rieke CJ, Garavito RM, Smith WL.

J Biol Chem. 2004 Oct 8;279(41):42929-35. Epub 2004 Jul 30.

PMID:
15292194
[PubMed - indexed for MEDLINE]
Free Article
4.

Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.

Malkowski MG, Thuresson ED, Lakkides KM, Rieke CJ, Micielli R, Smith WL, Garavito RM.

J Biol Chem. 2001 Oct 5;276(40):37547-55. Epub 2001 Jul 27.

PMID:
11477109
[PubMed - indexed for MEDLINE]
Free Article
5.

Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid.

Thuresson ED, Lakkides KM, Rieke CJ, Sun Y, Wingerd BA, Micielli R, Mulichak AM, Malkowski MG, Garavito RM, Smith WL.

J Biol Chem. 2001 Mar 30;276(13):10347-57. Epub 2000 Dec 19.

PMID:
11121412
[PubMed - indexed for MEDLINE]
Free Article
6.

The structures of prostaglandin endoperoxide H synthases-1 and -2.

Garavito RM, Malkowski MG, DeWitt DL.

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:129-52. Review.

PMID:
12432914
[PubMed - indexed for MEDLINE]
7.
8.

Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.

Tsai AL, Palmer G, Wu G, Peng S, Okeley NM, van der Donk WA, Kulmacz RJ.

J Biol Chem. 2002 Oct 11;277(41):38311-21. Epub 2002 Aug 6.

PMID:
12167656
[PubMed - indexed for MEDLINE]
Free Article
9.

Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX.

Tsai Al, Palmer G, Xiao G, Swinney DC, Kulmacz RJ.

J Biol Chem. 1998 Feb 13;273(7):3888-94.

PMID:
9461572
[PubMed - indexed for MEDLINE]
Free Article
10.

Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases.

Seibold SA, Ball T, Hsi LC, Mills DA, Abeysinghe RD, Micielli R, Rieke CJ, Cukier RI, Smith WL.

J Biol Chem. 2003 Nov 14;278(46):46163-70. Epub 2003 Sep 2.

PMID:
12952981
[PubMed - indexed for MEDLINE]
Free Article
11.

Structural insights into the stereochemistry of the cyclooxygenase reaction.

Kiefer JR, Pawlitz JL, Moreland KT, Stegeman RA, Hood WF, Gierse JK, Stevens AM, Goodwin DC, Rowlinson SW, Marnett LJ, Stallings WC, Kurumbail RG.

Nature. 2000 May 4;405(6782):97-101.

PMID:
10811226
[PubMed - indexed for MEDLINE]
12.

Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.

Xiao G, Tsai AL, Palmer G, Boyar WC, Marshall PJ, Kulmacz RJ.

Biochemistry. 1997 Feb 18;36(7):1836-45.

PMID:
9048568
[PubMed - indexed for MEDLINE]
13.

Picture story. COX complexes.

Feng H.

Nat Struct Biol. 2000 Jun;7(6):448. No abstract available.

PMID:
10881188
[PubMed - indexed for MEDLINE]
14.
15.

The enzymology of prostaglandin endoperoxide H synthases-1 and -2.

Smith WL, Song I.

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:115-28. Review.

PMID:
12432913
[PubMed - indexed for MEDLINE]
16.

Peroxidase activity in prostaglandin endoperoxide H synthase-1 occurs with a neutral histidine proximal heme ligand.

Seibold SA, Cerda JF, Mulichak AM, Song I, Garavito RM, Arakawa T, Smith WL, Babcock GT.

Biochemistry. 2000 Jun 6;39(22):6616-24.

PMID:
10828979
[PubMed - indexed for MEDLINE]
17.
18.

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase.

Loll PJ, Picot D, Garavito RM.

Nat Struct Biol. 1995 Aug;2(8):637-43.

PMID:
7552725
[PubMed - indexed for MEDLINE]
19.

Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs.

Smith WL, DeWitt DL.

Semin Nephrol. 1995 May;15(3):179-94. Review.

PMID:
7631045
[PubMed - indexed for MEDLINE]
20.

Dynamics of different arachidonic acid orientations bound to prostaglandin endoperoxide synthases.

Sachett LG, Verli H.

Eur J Med Chem. 2011 Oct;46(10):5212-7. doi: 10.1016/j.ejmech.2011.08.016. Epub 2011 Aug 16.

PMID:
21864948
[PubMed - indexed for MEDLINE]

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