Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 109

1.

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase.

Solans A, Estivill X, de La Luna S.

Cytogenet Cell Genet. 2000;89(3-4):177-84.

PMID:
10965118
[PubMed - indexed for MEDLINE]
2.

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9712-7.

PMID:
10931940
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter.

Maloney B, Ge YW, Greig NH, Lahiri DK.

J Mol Neurosci. 2006;29(1):81-99.

PMID:
16757812
[PubMed - indexed for MEDLINE]
4.

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.

Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, Song W.

FASEB J. 2005 May;19(7):739-49.

PMID:
15857888
[PubMed - indexed for MEDLINE]
Free Article
5.

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region.

Acquati F, Accarino M, Nucci C, Fumagalli P, Jovine L, Ottolenghi S, Taramelli R.

FEBS Lett. 2000 Feb 18;468(1):59-64.

PMID:
10683441
[PubMed - indexed for MEDLINE]
Free Article
6.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.

Science. 1999 Oct 22;286(5440):735-41.

PMID:
10531052
[PubMed - indexed for MEDLINE]
Free Article
7.

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ.

J Biol Chem. 2003 Jun 6;278(23):21286-94. Epub 2003 Mar 27.

PMID:
12665519
[PubMed - indexed for MEDLINE]
Free Article
8.

The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

Stockley JH, O'Neill C.

Biochem Soc Trans. 2007 Jun;35(Pt 3):574-6. Review.

PMID:
17511655
[PubMed - indexed for MEDLINE]
9.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
[PubMed - indexed for MEDLINE]
10.

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.

Nature. 1999 Dec 2;402(6761):533-7.

PMID:
10591213
[PubMed - indexed for MEDLINE]
11.

BACE2 functions as an alternative alpha-secretase in cells.

Yan R, Munzner JB, Shuck ME, Bienkowski MJ.

J Biol Chem. 2001 Sep 7;276(36):34019-27. Epub 2001 Jun 22.

PMID:
11423558
[PubMed - indexed for MEDLINE]
Free Article
12.

BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.

Sun X, He G, Song W.

FASEB J. 2006 Jul;20(9):1369-76.

PMID:
16816112
[PubMed - indexed for MEDLINE]
Free Article
13.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
[PubMed - indexed for MEDLINE]
14.

Insights from modeling the tertiary structure of human BACE2.

Chou KC.

J Proteome Res. 2004 Sep-Oct;3(5):1069-72.

PMID:
15473697
[PubMed - indexed for MEDLINE]
15.

Beta-secretase (BACE) as a drug target for Alzheimer's disease.

Vassar R.

Adv Drug Deliv Rev. 2002 Dec 7;54(12):1589-602. Review.

PMID:
12453676
[PubMed - indexed for MEDLINE]
16.

Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein.

Michaud J, Kudoh J, Berry A, Bonne-Tamir B, Lalioti MD, Rossier C, Shibuya K, Kawasaki K, Asakawa S, Minoshima S, Shimizu N, Antonarakis SE, Scott HS.

Genomics. 2000 Aug 15;68(1):71-9.

PMID:
10950928
[PubMed - indexed for MEDLINE]
17.

Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.

Marcinkiewicz M, Seidah NG.

J Neurochem. 2000 Nov;75(5):2133-43.

PMID:
11032903
[PubMed - indexed for MEDLINE]
18.

Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells.

Lahiri DK, Maloney B, Ge YW.

J Mol Neurosci. 2006;29(1):65-80.

PMID:
16757811
[PubMed - indexed for MEDLINE]
19.

Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells.

Basi G, Frigon N, Barbour R, Doan T, Gordon G, McConlogue L, Sinha S, Zeller M.

J Biol Chem. 2003 Aug 22;278(34):31512-20. Epub 2003 Jun 11.

PMID:
12801932
[PubMed - indexed for MEDLINE]
Free Article
20.

Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?

Nawrot B.

Acta Biochim Pol. 2004;51(2):431-44. Review.

PMID:
15218540
[PubMed - indexed for MEDLINE]
Free Article
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk