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Results: 1 to 20 of 80

1.

Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.

Lee K, Deng X, Friedman E.

Cancer Res. 2000 Jul 1;60(13):3631-7.

PMID:
10910078
[PubMed - indexed for MEDLINE]
Free Article
2.

Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.

Lim S, Jin K, Friedman E.

J Biol Chem. 2002 Jul 12;277(28):25040-6. Epub 2002 Apr 29. Erratum in: J Biol Chem. 2004 Feb 6;279(6):5047.

PMID:
11980910
[PubMed - indexed for MEDLINE]
Free Article
3.

The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.

Lim S, Zou Y, Friedman E.

J Biol Chem. 2002 Dec 20;277(51):49438-45. Epub 2002 Oct 15.

PMID:
12384504
[PubMed - indexed for MEDLINE]
Free Article
4.

Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants.

Ewton DZ, Lee K, Deng X, Lim S, Friedman E.

Int J Cancer. 2003 Jan 1;103(1):21-8.

PMID:
12455049
[PubMed - indexed for MEDLINE]
5.

The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.

Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, Friedman E.

Cancer Res. 2006 Apr 15;66(8):4149-58.

PMID:
16618736
[PubMed - indexed for MEDLINE]
Free Article
6.

Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells.

Sauma S, Yan Z, Ohno S, Friedman E.

Cell Growth Differ. 1996 May;7(5):587-94.

PMID:
8732668
[PubMed - indexed for MEDLINE]
Free Article
7.

Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation.

Deng X, Ewton DZ, Pawlikowski B, Maimone M, Friedman E.

J Biol Chem. 2003 Oct 17;278(42):41347-54. Epub 2003 Aug 5.

PMID:
12902328
[PubMed - indexed for MEDLINE]
Free Article
8.

The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.

Jin K, Park S, Ewton DZ, Friedman E.

Cancer Res. 2007 Aug 1;67(15):7247-55.

PMID:
17671193
[PubMed - indexed for MEDLINE]
Free Article
9.

The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling.

Jin K, Lim S, Mercer SE, Friedman E.

J Biol Chem. 2005 Dec 23;280(51):42097-105. Epub 2005 Oct 27.

PMID:
16257974
[PubMed - indexed for MEDLINE]
Free Article
10.

The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.

Deng X, Mercer SE, Shah S, Ewton DZ, Friedman E.

J Biol Chem. 2004 May 21;279(21):22498-504. Epub 2004 Mar 9.

PMID:
15010468
[PubMed - indexed for MEDLINE]
Free Article
11.

Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation.

Deng X, Ewton DZ, Mercer SE, Friedman E.

J Biol Chem. 2005 Feb 11;280(6):4894-905. Epub 2004 Nov 16.

PMID:
15546868
[PubMed - indexed for MEDLINE]
Free Article
12.

Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival.

Mercer SE, Friedman E.

Cell Biochem Biophys. 2006;45(3):303-15. Review.

PMID:
16845176
[PubMed - indexed for MEDLINE]
13.

Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.

Zou Y, Lim S, Lee K, Deng X, Friedman E.

J Biol Chem. 2003 Dec 5;278(49):49573-81. Epub 2003 Sep 18.

PMID:
14500717
[PubMed - indexed for MEDLINE]
Free Article
14.

Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.

Mercer SE, Ewton DZ, Shah S, Naqvi A, Friedman E.

Cancer Res. 2006 May 15;66(10):5143-50.

PMID:
16707437
[PubMed - indexed for MEDLINE]
Free Article
15.

Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

Yang R, Piperdi S, Gorlick R.

Clin Cancer Res. 2008 Oct 15;14(20):6396-404. doi: 10.1158/1078-0432.CCR-07-5113.

PMID:
18927278
[PubMed - indexed for MEDLINE]
Free Article
16.

Mirk regulates the exit of colon cancer cells from quiescence.

Jin K, Ewton DZ, Park S, Hu J, Friedman E.

J Biol Chem. 2009 Aug 21;284(34):22916-25. doi: 10.1074/jbc.M109.035519. Epub 2009 Jun 19.

PMID:
19542220
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.

Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E.

J Biol Chem. 2004 Jun 25;279(26):27790-8. Epub 2004 Apr 9.

PMID:
15075324
[PubMed - indexed for MEDLINE]
Free Article
18.

Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.

Lee HW, Ahn DH, Crawley SC, Li JD, Gum JR Jr, Basbaum CB, Fan NQ, Szymkowski DE, Han SY, Lee BH, Sleisenger MH, Kim YS.

J Biol Chem. 2002 Sep 6;277(36):32624-31. Epub 2002 Jun 20.

PMID:
12077118
[PubMed - indexed for MEDLINE]
Free Article
19.

A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.

Matsuguchi T, Musikacharoen T, Johnson TR, Kraft AS, Yoshikai Y.

Mol Cell Biol. 2001 Oct;21(20):6999-7009.

PMID:
11564882
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery.

Okano J, Rustgi AK.

J Biol Chem. 2001 Jun 1;276(22):19555-64. Epub 2001 Mar 5.

PMID:
11278851
[PubMed - indexed for MEDLINE]
Free Article

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