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Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.

Mothe-Satney I, Yang D, Fadden P, Haystead TA, Lawrence JC Jr.

Mol Cell Biol. 2000 May;20(10):3558-67.


Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.

Ferguson G, Mothe-Satney I, Lawrence JC Jr.

J Biol Chem. 2003 Nov 28;278(48):47459-65. Epub 2003 Sep 24.


Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies.

Mothe-Satney I, Brunn GJ, McMahon LP, Capaldo CT, Abraham RT, Lawrence JC Jr.

J Biol Chem. 2000 Oct 27;275(43):33836-43.


Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.

Brunn GJ, Hudson CC, Sekulić A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC Jr, Abraham RT.

Science. 1997 Jul 4;277(5322):99-101.


Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation.

Xu G, Marshall CA, Lin TA, Kwon G, Munivenkatappa RB, Hill JR, Lawrence JC Jr, McDaniel ML.

J Biol Chem. 1998 Feb 20;273(8):4485-91.


PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.

Lawrence JC Jr, Fadden P, Haystead TA, Lin TA.

Adv Enzyme Regul. 1997;37:239-67. Review.


Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2.

Fadden P, Haystead TA, Lawrence JC Jr.

FEBS Lett. 1998 Sep 11;435(1):105-9.


The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.

McMahon LP, Choi KM, Lin TA, Abraham RT, Lawrence JC Jr.

Mol Cell Biol. 2002 Nov;22(21):7428-38.


Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1).

Heesom KJ, Gampel A, Mellor H, Denton RM.

Curr Biol. 2001 Sep 4;11(17):1374-9.


Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

Scheper GC, van Kollenburg B, Hu J, Luo Y, Goss DJ, Proud CG.

J Biol Chem. 2002 Feb 1;277(5):3303-9. Epub 2001 Nov 26.


Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin.

Long W, Saffer L, Wei L, Barrett EJ.

Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E301-6.


Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.

Scheper GC, Mulder J, Kleijn M, Voorma HO, Thomas AA, van Wijk R.

J Biol Chem. 1997 Oct 24;272(43):26850-6.


Hierarchical phosphorylation of the translation inhibitor 4E-BP1.

Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R, Sonenberg N.

Genes Dev. 2001 Nov 1;15(21):2852-64.

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