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Items: 1 to 20 of 405

1.

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.

Imai S, Armstrong CM, Kaeberlein M, Guarente L.

Nature. 2000 Feb 17;403(6771):795-800.

PMID:
10693811
2.

Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation.

Hoppe GJ, Tanny JC, Rudner AD, Gerber SA, Danaie S, Gygi SP, Moazed D.

Mol Cell Biol. 2002 Jun;22(12):4167-80.

3.

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.

Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11.

4.

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.

Sauve AA, Moir RD, Schramm VL, Willis IM.

Mol Cell. 2005 Feb 18;17(4):595-601.

5.
6.

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing.

Tanny JC, Dowd GJ, Huang J, Hilz H, Moazed D.

Cell. 1999 Dec 23;99(7):735-45.

7.

Identification of a small molecule inhibitor of Sir2p.

Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8.

8.

Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern.

Braunstein M, Sobel RE, Allis CD, Turner BM, Broach JR.

Mol Cell Biol. 1996 Aug;16(8):4349-56.

9.

Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation.

Zhou J, Zhou BO, Lenzmeier BA, Zhou JQ.

Nucleic Acids Res. 2009 Jun;37(11):3699-713. doi: 10.1093/nar/gkp233. Epub 2009 Apr 16.

10.

Enzymatic activities of Sir2 and chromatin silencing.

Moazed D.

Curr Opin Cell Biol. 2001 Apr;13(2):232-8. Review.

PMID:
11248558
11.

Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast.

Shankaranarayana GD, Motamedi MR, Moazed D, Grewal SI.

Curr Biol. 2003 Jul 15;13(14):1240-6.

12.

Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation.

Kristjuhan A, Wittschieben BO, Walker J, Roberts D, Cairns BR, Svejstrup JQ.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7551-6. Epub 2003 Jun 9.

13.

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Smith JS, Brachmann CB, Celic I, Kenna MA, Muhammad S, Starai VJ, Avalos JL, Escalante-Semerena JC, Grubmeyer C, Wolberger C, Boeke JD.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6658-63.

14.
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16.

A model for step-wise assembly of heterochromatin in yeast.

Moazed D, Rudner AD, Huang J, Hoppe GJ, Tanny JC.

Novartis Found Symp. 2004;259:48-56; discussion 56-62, 163-9. Review.

PMID:
15171246
18.

Human Sir2 and the 'silencing' of p53 activity.

Smith J.

Trends Cell Biol. 2002 Sep;12(9):404-6.

PMID:
12220851
19.

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.

Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL.

J Biol Chem. 2001 Oct 19;276(42):38837-43. Epub 2001 Aug 1.

20.
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