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Results: 1 to 20 of 238

1.

Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.

Cruz MC, Cavallo LM, Görlach JM, Cox G, Perfect JR, Cardenas ME, Heitman J.

Mol Cell Biol. 1999 Jun;19(6):4101-12.

PMID:
10330150
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.

Cruz MC, Goldstein AL, Blankenship J, Del Poeta M, Perfect JR, McCusker JH, Bennani YL, Cardenas ME, Heitman J.

Antimicrob Agents Chemother. 2001 Nov;45(11):3162-70.

PMID:
11600372
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

Lorenz MC, Heitman J.

J Biol Chem. 1995 Nov 17;270(46):27531-7.

PMID:
7499212
[PubMed - indexed for MEDLINE]
Free Article
4.

Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.

Arndt C, Cruz MC, Cardenas ME, Heitman J.

Microbiology. 1999 Aug;145 ( Pt 8):1989-2000.

PMID:
10463165
[PubMed - indexed for MEDLINE]
Free Article
5.

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.

Weisman R, Choder M.

J Biol Chem. 2001 Mar 9;276(10):7027-32. Epub 2000 Nov 28.

PMID:
11096119
[PubMed - indexed for MEDLINE]
Free Article
6.

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.

Alarcon CM, Heitman J, Cardenas ME.

Mol Biol Cell. 1999 Aug;10(8):2531-46.

PMID:
10436010
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM, Faucette L, Eng WK, Johnson RK, Livi GP.

Mol Cell Biol. 1993 Oct;13(10):6012-23.

PMID:
8413204
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.

Stan R, McLaughlin MM, Cafferkey R, Johnson RK, Rosenberg M, Livi GP.

J Biol Chem. 1994 Dec 23;269(51):32027-30.

PMID:
7528205
[PubMed - indexed for MEDLINE]
Free Article
9.

Calcineurin is required for virulence of Cryptococcus neoformans.

Odom A, Muir S, Lim E, Toffaletti DL, Perfect J, Heitman J.

EMBO J. 1997 May 15;16(10):2576-89.

PMID:
9184205
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.

Bastidas RJ, Shertz CA, Lee SC, Heitman J, Cardenas ME.

Eukaryot Cell. 2012 Mar;11(3):270-81. doi: 10.1128/EC.05284-11. Epub 2011 Dec 30.

PMID:
22210828
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals.

Cutler NS, Heitman J, Cardenas ME.

Mol Cell Endocrinol. 1999 Sep 10;155(1-2):135-42. Review.

PMID:
10580846
[PubMed - indexed for MEDLINE]
12.

The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.

Odom A, Del Poeta M, Perfect J, Heitman J.

Antimicrob Agents Chemother. 1997 Jan;41(1):156-61.

PMID:
8980772
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.

Alarcon CM, Cardenas ME, Heitman J.

Genes Dev. 1996 Feb 1;10(3):279-88.

PMID:
8595879
[PubMed - indexed for MEDLINE]
Free Article
14.

FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast.

Kunz J, Loeschmann A, Deuter-Reinhard M, Hall MN.

Mol Microbiol. 2000 Sep;37(6):1480-93. Erratum in: Mol Microbiol 2001 Feb;39(4):1107.

PMID:
10998178
[PubMed - indexed for MEDLINE]
15.

Missense mutations at the FKBP12-rapamycin-binding site of TOR1.

Freeman K, Livi GP.

Gene. 1996 Jun 12;172(1):143-7.

PMID:
8654975
[PubMed - indexed for MEDLINE]
16.

Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin.

Xu Q, Liang S, Kudla J, Luan S.

Plant J. 1998 Aug;15(4):511-9.

PMID:
9753776
[PubMed - indexed for MEDLINE]
17.

Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.

Dolinski KJ, Heitman J.

Genetics. 1999 Mar;151(3):935-44.

PMID:
10049913
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.

Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH.

Cell. 1994 Jul 15;78(1):35-43.

PMID:
7518356
[PubMed - indexed for MEDLINE]
19.

Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii.

Crespo JL, Díaz-Troya S, Florencio FJ.

Plant Physiol. 2005 Dec;139(4):1736-49. Epub 2005 Nov 18.

PMID:
16299168
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

Chiu MI, Katz H, Berlin V.

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12574-8.

PMID:
7809080
[PubMed - indexed for MEDLINE]
Free PMC Article

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