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Items: 1 to 20 of 111

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Definition of the p53 functional domains necessary for inducing apoptosis.

Zhu J, Zhang S, Jiang J, Chen X.

J Biol Chem. 2000 Dec 22;275(51):39927-34.

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Mechanisms of differential activation of target gene promoters by p53 hinge domain mutants with impaired apoptotic function.

Kong XT, Gao H, Stanbridge EJ.

J Biol Chem. 2001 Aug 31;276(35):32990-3000. Epub 2001 Jun 6.

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A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function.

Kokontis JM, Wagner AJ, O'Leary M, Liao S, Hay N.

Oncogene. 2001 Feb 8;20(6):659-68.

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The C terminus of p53 family proteins is a cell fate determinant.

Harms KL, Chen X.

Mol Cell Biol. 2005 Mar;25(5):2014-30.

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Characterization of p73 functional domains necessary for transactivation and growth suppression.

Nozell S, Wu Y, McNaughton K, Liu G, Willis A, Paik JC, Chen X.

Oncogene. 2003 Jul 10;22(28):4333-47.

PMID:
12853970
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Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.

Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM.

Mol Cell Biol. 2007 Feb;27(4):1425-32. Epub 2006 Dec 11.

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Identification of a novel p53 functional domain that is necessary for efficient growth suppression.

Walker KK, Levine AJ.

Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15335-40.

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Identification of a novel p53 functional domain that is necessary for mediating apoptosis.

Zhu J, Zhou W, Jiang J, Chen X.

J Biol Chem. 1998 May 22;273(21):13030-6.

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Isolation and characterization of fourteen novel putative and nine known target genes of the p53 family.

Chen X, Liu G, Zhu J, Jiang J, Nozell S, Willis A.

Cancer Biol Ther. 2003 Jan-Feb;2(1):55-62.

PMID:
12673118
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p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements.

Campomenosi P, Monti P, Aprile A, Abbondandolo A, Frebourg T, Gold B, Crook T, Inga A, Resnick MA, Iggo R, Fronza G.

Oncogene. 2001 Jun 14;20(27):3573-9.

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Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.

Liu WL, Midgley C, Stephen C, Saville M, Lane DP.

J Mol Biol. 2001 Nov 2;313(4):711-31.

PMID:
11697899
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Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes.

Amano T, Nakamizo A, Mishra SK, Gumin J, Shinojima N, Sawaya R, Lang FF.

J Neurooncol. 2009 May;92(3):357-71. doi: 10.1007/s11060-009-9844-1. Epub 2009 Apr 9.

PMID:
19357962
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