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Items: 1 to 20 of 139

1.
2.

Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.

Meyer SG, Wendt AE, Scherer M, Liebisch G, Kerkweg U, Schmitz G, de Groot H.

Arch Biochem Biophys. 2012 Oct 1;526(1):60-8. doi: 10.1016/j.abb.2012.07.006. Epub 2012 Jul 24.

PMID:
22841978
3.

Sphingolipid signaling mediates iron toxicity.

Lee YJ, Huang X, Kropat J, Henras A, Merchant SS, Dickson RC, Chanfreau GF.

Cell Metab. 2012 Jul 3;16(1):90-6. doi: 10.1016/j.cmet.2012.06.004.

4.

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

Ussher JR, Folmes CD, Keung W, Fillmore N, Jaswal JS, Cadete VJ, Beker DL, Lam VH, Zhang L, Lopaschuk GD.

PLoS One. 2012;7(5):e37703. doi: 10.1371/journal.pone.0037703. Epub 2012 May 22.

5.

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.

Gorshkova I, Zhou T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG, Berdyshev EV.

J Lipid Res. 2012 Aug;53(8):1553-68. doi: 10.1194/jlr.M026039. Epub 2012 May 21.

6.

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex.

Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD.

Diabetes. 2012 Jul;61(7):1848-59. doi: 10.2337/db11-1399. Epub 2012 May 14.

7.

Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.

Chiba K, Adachi K.

Future Med Chem. 2012 Apr;4(6):771-81. doi: 10.4155/fmc.12.25. Review.

PMID:
22530640
8.

Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells.

Kubo T, Ishida K, Matsuo J, Nakamura S, Hayashi Y, Sakai H, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Yamaguchi H.

Microb Pathog. 2012 Jul;53(1):1-11. doi: 10.1016/j.micpath.2012.02.005. Epub 2012 Apr 10.

PMID:
22516802
9.

Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.

Podbielska M, Krotkiewski H, Hogan EL.

Neurochem Res. 2012 Jun;37(6):1154-69. doi: 10.1007/s11064-012-0728-y. Epub 2012 Mar 27. Review.

PMID:
22451227
10.

Ceramide profiles in the brain of rats with diabetes induced by streptozotocin.

Car H, Zendzian-Piotrowska M, Prokopiuk S, Fiedorowicz A, Sadowska A, Kurek K, Sawicka D.

FEBS J. 2012 Jun;279(11):1943-52. doi: 10.1111/j.1742-4658.2012.08575.x. Epub 2012 Apr 16.

11.

Ceramides inhibit phospholipase D-dependent insulin signaling in liver cells of old rats.

Babenko NA, Kharchenko VS.

Biochemistry (Mosc). 2012 Feb;77(2):180-6. doi: 10.1134/S0006297912020095.

PMID:
22348478
12.

Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis.

Lee YS, Choi KM, Lee S, Sin DM, Lim Y, Lee YM, Hong JT, Yun YP, Yoo HS.

Cancer Biol Ther. 2012 Jan 15;13(2):92-100. doi: 10.4161/cbt.13.2.18870.

PMID:
22336910
13.

Down-regulating sphingolipid synthesis increases yeast lifespan.

Huang X, Liu J, Dickson RC.

PLoS Genet. 2012 Feb;8(2):e1002493. doi: 10.1371/journal.pgen.1002493. Epub 2012 Feb 2.

14.

Terpene alcohols inhibit de novo sphingolipid biosynthesis.

Shin KO, Park MY, Seo CH, Lee YI, Kim HS, Yoo HS, Hong JT, Jung JK, Lee YM.

Planta Med. 2012 Mar;78(5):434-9. doi: 10.1055/s-0031-1298155. Epub 2012 Jan 24.

PMID:
22274813
15.

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.

Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19222-7. doi: 10.1073/pnas.1116948108. Epub 2011 Nov 11.

16.

Sphingolipids and cardiovascular diseases: lipoprotein metabolism, atherosclerosis and cardiomyopathy.

Jiang XC, Goldberg IJ, Park TS.

Adv Exp Med Biol. 2011;721:19-39. doi: 10.1007/978-1-4614-0650-1_2. Review.

PMID:
21910080
17.

Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation.

Lattif AA, Mukherjee PK, Chandra J, Roth MR, Welti R, Rouabhia M, Ghannoum MA.

Microbiology. 2011 Nov;157(Pt 11):3232-42. doi: 10.1099/mic.0.051086-0. Epub 2011 Sep 8.

18.

Effects of serine palmitoyltransferase inhibitor ISP-I on the stratum corneum of intact mouse skin.

Mizukoshi K, Matsumoto K, Hirose R, Fujita T, Ishida-Yamamoto A, Iizuka H.

Biol Pharm Bull. 2011;34(9):1383-9.

19.

[Effect of myriocin on the expression of cyclinD1 in high glucose-induced hypertrophy mesangial cells].

Xiao ZH, Zhou JH, Wu HS.

Zhongguo Dang Dai Er Ke Za Zhi. 2011 Aug;13(8):677-9. Chinese.

20.

Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy.

Caviglia JM, Gayet C, Ota T, Hernandez-Ono A, Conlon DM, Jiang H, Fisher EA, Ginsberg HN.

J Lipid Res. 2011 Sep;52(9):1636-51. doi: 10.1194/jlr.M016931. Epub 2011 Jun 30.

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