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Results: 1 to 20 of 139

1.

The essential structures of ISP-I that influence serine palmitoyltransferase inhibition in Chinese hamster ovary cells.

Mizukoshi K, Matsumoto K, Hirose R, Fujita T.

Biol Pharm Bull. 2012;35(8):1349-53.

PMID:
22863936
[PubMed - indexed for MEDLINE]
Free Article
2.

Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.

Meyer SG, Wendt AE, Scherer M, Liebisch G, Kerkweg U, Schmitz G, de Groot H.

Arch Biochem Biophys. 2012 Oct 1;526(1):60-8. doi: 10.1016/j.abb.2012.07.006. Epub 2012 Jul 24.

PMID:
22841978
[PubMed - indexed for MEDLINE]
3.

Sphingolipid signaling mediates iron toxicity.

Lee YJ, Huang X, Kropat J, Henras A, Merchant SS, Dickson RC, Chanfreau GF.

Cell Metab. 2012 Jul 3;16(1):90-6. doi: 10.1016/j.cmet.2012.06.004.

PMID:
22768841
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

Ussher JR, Folmes CD, Keung W, Fillmore N, Jaswal JS, Cadete VJ, Beker DL, Lam VH, Zhang L, Lopaschuk GD.

PLoS One. 2012;7(5):e37703. doi: 10.1371/journal.pone.0037703. Epub 2012 May 22.

PMID:
22629445
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.

Gorshkova I, Zhou T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG, Berdyshev EV.

J Lipid Res. 2012 Aug;53(8):1553-68. doi: 10.1194/jlr.M026039. Epub 2012 May 21.

PMID:
22615416
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex.

Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD.

Diabetes. 2012 Jul;61(7):1848-59. doi: 10.2337/db11-1399. Epub 2012 May 14.

PMID:
22586587
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.

Chiba K, Adachi K.

Future Med Chem. 2012 Apr;4(6):771-81. doi: 10.4155/fmc.12.25. Review.

PMID:
22530640
[PubMed - indexed for MEDLINE]
8.

Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells.

Kubo T, Ishida K, Matsuo J, Nakamura S, Hayashi Y, Sakai H, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Yamaguchi H.

Microb Pathog. 2012 Jul;53(1):1-11. doi: 10.1016/j.micpath.2012.02.005. Epub 2012 Apr 10.

PMID:
22516802
[PubMed - indexed for MEDLINE]
9.

Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.

Podbielska M, Krotkiewski H, Hogan EL.

Neurochem Res. 2012 Jun;37(6):1154-69. doi: 10.1007/s11064-012-0728-y. Epub 2012 Mar 27. Review.

PMID:
22451227
[PubMed - indexed for MEDLINE]
10.

Ceramide profiles in the brain of rats with diabetes induced by streptozotocin.

Car H, Zendzian-Piotrowska M, Prokopiuk S, Fiedorowicz A, Sadowska A, Kurek K, Sawicka D.

FEBS J. 2012 Jun;279(11):1943-52. doi: 10.1111/j.1742-4658.2012.08575.x. Epub 2012 Apr 16.

PMID:
22429392
[PubMed - indexed for MEDLINE]
11.

Ceramides inhibit phospholipase D-dependent insulin signaling in liver cells of old rats.

Babenko NA, Kharchenko VS.

Biochemistry (Mosc). 2012 Feb;77(2):180-6. doi: 10.1134/S0006297912020095.

PMID:
22348478
[PubMed - indexed for MEDLINE]
12.

Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis.

Lee YS, Choi KM, Lee S, Sin DM, Lim Y, Lee YM, Hong JT, Yun YP, Yoo HS.

Cancer Biol Ther. 2012 Jan 15;13(2):92-100. doi: 10.4161/cbt.13.2.18870.

PMID:
22336910
[PubMed - indexed for MEDLINE]
13.

Down-regulating sphingolipid synthesis increases yeast lifespan.

Huang X, Liu J, Dickson RC.

PLoS Genet. 2012 Feb;8(2):e1002493. doi: 10.1371/journal.pgen.1002493. Epub 2012 Feb 2.

PMID:
22319457
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Terpene alcohols inhibit de novo sphingolipid biosynthesis.

Shin KO, Park MY, Seo CH, Lee YI, Kim HS, Yoo HS, Hong JT, Jung JK, Lee YM.

Planta Med. 2012 Mar;78(5):434-9. doi: 10.1055/s-0031-1298155. Epub 2012 Jan 24.

PMID:
22274813
[PubMed - indexed for MEDLINE]
15.

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.

Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19222-7. doi: 10.1073/pnas.1116948108. Epub 2011 Nov 11.

PMID:
22080611
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Sphingolipids and cardiovascular diseases: lipoprotein metabolism, atherosclerosis and cardiomyopathy.

Jiang XC, Goldberg IJ, Park TS.

Adv Exp Med Biol. 2011;721:19-39. doi: 10.1007/978-1-4614-0650-1_2. Review.

PMID:
21910080
[PubMed - indexed for MEDLINE]
17.

Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation.

Lattif AA, Mukherjee PK, Chandra J, Roth MR, Welti R, Rouabhia M, Ghannoum MA.

Microbiology. 2011 Nov;157(Pt 11):3232-42. doi: 10.1099/mic.0.051086-0. Epub 2011 Sep 8.

PMID:
21903752
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Effects of serine palmitoyltransferase inhibitor ISP-I on the stratum corneum of intact mouse skin.

Mizukoshi K, Matsumoto K, Hirose R, Fujita T, Ishida-Yamamoto A, Iizuka H.

Biol Pharm Bull. 2011;34(9):1383-9.

PMID:
21881222
[PubMed - indexed for MEDLINE]
Free Article
19.

[Effect of myriocin on the expression of cyclinD1 in high glucose-induced hypertrophy mesangial cells].

Xiao ZH, Zhou JH, Wu HS.

Zhongguo Dang Dai Er Ke Za Zhi. 2011 Aug;13(8):677-9. Chinese.

PMID:
21849123
[PubMed - indexed for MEDLINE]
Free Article
20.

Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy.

Caviglia JM, Gayet C, Ota T, Hernandez-Ono A, Conlon DM, Jiang H, Fisher EA, Ginsberg HN.

J Lipid Res. 2011 Sep;52(9):1636-51. doi: 10.1194/jlr.M016931. Epub 2011 Jun 30.

PMID:
21719579
[PubMed - indexed for MEDLINE]
Free PMC Article

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