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Items: 8

1.

Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.

Richter JM, Schaefer M, Hill K.

Mol Pharmacol. 2014 Nov;86(5):514-21. doi: 10.1124/mol.114.093229. Epub 2014 Aug 19.

2.

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position.

Vlahakis JZ, Vukomanovic D, Nakatsu K, Szarek WA.

Bioorg Med Chem. 2013 Nov 1;21(21):6788-95. doi: 10.1016/j.bmc.2013.07.050. Epub 2013 Aug 8.

PMID:
24021581
3.

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.

Baraban SC, Dinday MT, Hortopan GA.

Nat Commun. 2013;4:2410. doi: 10.1038/ncomms3410.

4.

Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.

Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltz G.

J Pharmacol Exp Ther. 2013 Feb;344(2):388-96. doi: 10.1124/jpet.112.198697. Epub 2012 Nov 8. Erratum in: J Pharmacol Exp Ther. 2013 May;345(2):327. Nishimura, Toshiko [corrected to Nishimura, Toshihiko].

5.

The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors.

Einav S, Sobol HD, Gehrig E, Glenn JS.

J Infect Dis. 2010 Jul 1;202(1):65-74. doi: 10.1086/653080.

6.

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

Einav S, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR.

Nat Biotechnol. 2008 Sep;26(9):1019-27. doi: 10.1038/nbt.1490.

7.

Clemizoledichlorocobalt(II).

Parvez M, Braitenbach K.

Acta Crystallogr C. 2000 Aug;56 ( Pt 8):919-20.

PMID:
10944272
8.

Determination of antihistamines based on the formation of mixed aggregates with surfactants.

San Andrés MP, Sicilia D, Rubio S, Pérez-Bendito D.

Analyst. 1998 May;123(5):1079-84.

PMID:
9709492
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