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Items: 4

1.

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Vasquez-Martinez Y, Ohri RV, Kenyon V, Holman TR, SepĂșlveda-Boza S.

Bioorg Med Chem. 2007 Dec 1;15(23):7408-25. Epub 2007 Aug 22.

2.

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR.

Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.

3.

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8. Epub 2006 Jul 24.

4.

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

Deschamps JD, Kenyon VA, Holman TR.

Bioorg Med Chem. 2006 Jun 15;14(12):4295-301. Epub 2006 Feb 24.

PMID:
16500106
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